USF2

USF2
Identifiers
Aliases	USF2, FIP, bHLHb12, upstream transcription factor 2, c-fos interacting
External IDs	OMIM: 600390 MGI: 99961 HomoloGene: 2527 GeneCards: USF2
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	35,279,821 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	30,656,228 bp[2]
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; anterior pituitary; ; right lobe of thyroid gland; ; nucleus accumbens; ; tibial nerve; ; left lobe of thyroid gland; ; amygdala; ; prefrontal cortex; ; putamen; ; olfactory bulb;
	Top expressed in
	superior frontal gyrus; ; lip; ; yolk sac; ; mirror; ; cerebellar cortex; ; thymus; ; esophagus; ; bone marrow; ; right ventricle; ; ganglionic eminence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; bHLH transcription factor binding; protein binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular membrane-bounded organelle; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; positive regulation of transcription from RNA polymerase II promoter by glucose; regulation of transcription by RNA polymerase II; late viral transcription; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of transcription from RNA polymerase II promoter by glucose; lipid homeostasis; lactation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7392
	22282
	ENSG00000105698
	ENSMUSG00000058239
	Q15853
	Q64705
	NM_003367; NM_207291; NM_001321150
	NM_011680
	NP_001308079; NP_003358; NP_997174
	NP_035810
	Wikidata
View/Edit Human	View/Edit Mouse

Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.[5][6]

Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

Interactions

USF2 has been shown to interact with USF1 (human gene),[7][8] PPRC1[9] and BRCA1.[10]

Regulation

The USF2 gene is repressed by the microRNA miR-10a.[11]

References

GRCh38: Ensembl release 89: ENSG00000105698 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000058239 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Groenen PM, Garcia E, Debeer P, Devriendt K, Fryns JP, Van de Ven WJ (Dec 1996). "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia". Genomics. 38 (2): 141–8. doi:10.1006/geno.1996.0609. PMID 8954795.
"Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting".
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
Moore ML, Park EA, McMillin JB (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry. 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894.
Cable PL, Wilson CA, Calzone FJ, Rauscher FJ, Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA (Oct 2003). "Novel consensus DNA-binding sequence for BRCA1 protein complexes". Molecular Carcinogenesis. 38 (2): 85–96. doi:10.1002/mc.10148. PMID 14502648. S2CID 24956554.
Agirre X, Jiménez-Velasco A, San José-Enériz E, Garate L, Bandrés E, Cordeu L, Aparicio O, Saez B, Navarro G, Vilas-Zornoza A, Pérez-Roger I, García-Foncillas J, Torres A, Heiniger A, Calasanz MJ, Fortes P, Román-Gómez J, Prósper F (Dec 2008). "Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth". Molecular Cancer Research. 6 (12): 1830–40. doi:10.1158/1541-7786.MCR-08-0167. PMID 19074828.

External links

FactorBook USF2

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105698 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058239 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8954795-5] Groenen PM, Garcia E, Debeer P, Devriendt K, Fryns JP, Van de Ven WJ (Dec 1996). "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia". Genomics. 38 (2): 141–8. doi:10.1006/geno.1996.0609. PMID 8954795.

[entrez-6] "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting".

[pmid17353931-7] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid8576131-8] Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.

[pmid12611894-9] Moore ML, Park EA, McMillin JB (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry. 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894.

[pmid14502648-10] Cable PL, Wilson CA, Calzone FJ, Rauscher FJ, Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA (Oct 2003). "Novel consensus DNA-binding sequence for BRCA1 protein complexes". Molecular Carcinogenesis. 38 (2): 85–96. doi:10.1002/mc.10148. PMID 14502648. S2CID 24956554.

[pmid19074828-11] Agirre X, Jiménez-Velasco A, San José-Enériz E, Garate L, Bandrés E, Cordeu L, Aparicio O, Saez B, Navarro G, Vilas-Zornoza A, Pérez-Roger I, García-Foncillas J, Torres A, Heiniger A, Calasanz MJ, Fortes P, Román-Gómez J, Prósper F (Dec 2008). "Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth". Molecular Cancer Research. 6 (12): 1830–40. doi:10.1158/1541-7786.MCR-08-0167. PMID 19074828.