Valine—3-methyl-2-oxovalerate transaminase

In enzymology, a valine-3-methyl-2-oxovalerate transaminase (EC 2.6.1.32) is an enzyme that catalyzes the chemical reaction

L-valine + (S)-3-methyl-2-oxopentanoate 3-methyl-2-oxobutanoate + L-isoleucine
valine-3-methyl-2-oxovalerate transaminase
Identifiers
EC no.2.6.1.32
CAS no.9023-14-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are L-valine and (S)-3-methyl-2-oxopentanoate, whereas its two products are 3-methyl-2-oxobutanoate and L-isoleucine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase. Other names in common use include valine-isoleucine transaminase, valine-3-methyl-2-oxovalerate aminotransferase, alanine-valine transaminase, valine-2-keto-methylvalerate aminotransferase, and valine-isoleucine aminotransferase.

References

    • Kagan ZS, Dronov AS, Kretovich VL (1968). "[Some properties of valine-isoleucine- and valine-glutamate-aminotransferases of pea sprouts]". Doklady Akademii Nauk SSSR (in Russian). 179: 1236–1239.


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