Yoda1

Yoda1 is a chemical compound which is the first agonist developed for the mechanosensitive ion channel PIEZO1. This protein is involved in regulation of blood pressure and red blood cell volume, and Yoda1 is used in scientific research in these areas.[1][2][3][4][5]

Yoda1
Names
Preferred IUPAC name
2-(5-{[(2,6-Dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)pyrazine
Identifiers
3D model (JSmol)
ChEBI
UNII
  • ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1
Properties
C13H8Cl2N4S2
Molar mass 355.27 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

References
  1. Syeda, Ruhma; Xu, Jie; Dubin, Adrienne E.; Coste, Bertrand; Mathur, Jayanti; Huynh, Truc; Matzen, Jason; Lao, Jianmin; Tully, David C.; Engels, Ingo H.; Petrassi, H. Michael; Schumacher, Andrew M.; Montal, Mauricio; Bandell, Michael; Patapoutian, Ardem (2015). "Chemical activation of the mechanotransduction channel Piezo1". eLife. 4: e07369. doi:10.7554/eLife.07369. PMC 4456433. PMID 26001275. S2CID 2652667.
  2. Cahalan, Stuart M.; Lukacs, Viktor; Ranade, Sanjeev S.; Chien, Shu; Bandell, Michael; Patapoutian, Ardem (2015). "Piezo1 links mechanical forces to red blood cell volume". eLife. 4: e07370. doi:10.7554/eLife.07370. PMC 4456639. PMID 26001274. S2CID 15018525.
  3. Wang, ShengPeng; Chennupati, Ramesh; Kaur, Harmandeep; Iring, Andras; Wettschureck, Nina; Offermanns, Stefan (2016). "Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release". Journal of Clinical Investigation. 126 (12): 4527–4536. doi:10.1172/JCI87343. PMC 5127677. PMID 27797339. S2CID 38263363.
  4. Rapetti-Mauss, Raphaël; Picard, Véronique; Guitton, Corinne; Ghazal, Khaldoun; Proulle, Valérie; Badens, Catherine; Soriani, Olivier; Garçon, Loïc; Guizouarn, Hélène (2017). "Red blood cell Gardos channel (KCNN4): The essential determinant of erythrocyte dehydration in hereditary xerocytosis". Haematologica. 102 (10): e415–e418. doi:10.3324/haematol.2017.171389. PMC 5622875. PMID 28619848. S2CID 31756119.
  5. Gnanasambandam, R.; Gottlieb, P. A.; Sachs, F. (2017). "The kinetics and the permeation properties of Piezo channels". In Gottlieb, Philip A. (ed.). Piezo Channels. Current Topics in Membranes. Vol. 79. Academic Press. pp. 275–307. doi:10.1016/bs.ctm.2016.11.004. ISBN 978-0-12-809389-4. PMID 28728821. S2CID 3743286.


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