Ankyloblepharon

Ankyloblepharon is defined as the adhesion of the edges of the upper eyelid with the lower eyelid. Ankyloblepharon must be differentiated from blepharophimosis, in which palpebral aperture is reduced and there is telecanthus, but the eyelid margins are normal. Another condition similar to ankyloblepharon is symblepharon, in which the palpebral conjunctiva is attached to the bulbar conjunctiva. Recognition of ankyloblepharon necessitates systemic examination to detect associated abnormalities such as genitourinary and cardiac abnormalities and syndactyly.[1]

Ankyloblepharon
SpecialtyOphthalmology
ComplicationsAmblyopia (in congenital ankyloblepharon)
Usual onsetCongenital or acquired
TypesComplete, partial, and interrupted (ankyloblepharon filiforme adnatum)
Differential diagnosisSymblepharon
TreatmentSurgery

Presentation

Complication

The main complication of congenital ankyloblepharon is amblyopia. Timely separation of the eyelids is very important to avoid the development of occlusion amblyopia.[2]

Etiology

Ankyloblepharon may be congenital or acquired. The most common type is congenital.[3]

Clinically, ankyloblepharon may be complete, partial, or interrupted. Complete ankyloblepharon is when the eyelids are fused throughout the lid margins. In the partial form, they are joined at one or more points. The interrupted form is also known as ankyloblepharon filiforme adnatum (AFA).[4][5]

Congenital ankyloblepharon

During fetal development, eyelid margins remain fused until the fifth gestational month, and may not be completely separated until the seventh month of gestation.[6] Congenital ankyloblepharon occurs when the lid margins fail to separate at birth. The exact etiology of this condition is unknown. The currently accepted theory is that this condition is due to temporary epithelial arrest and rapid mesenchymal proliferation, allowing union of eyelids at abnormal positions.[7]

Systemic associations

Congenital ankyloblepharon is seen in association with:

  • Hay–Wells syndrome: Ankyloblepharon-Ectodermal dysplasia-Clefting (AEC) syndrome also known as Hay-Wells syndrome is a rare autosomal dominant disorder characterized by ankyloblepharon, ectodermal dysplasia, and cleft palate and/or cleft lip.[8]
  • Curly hair–ankyloblepharon–nail disease (CHAND) syndrome: it is a clinical variant of AEC syndrome. It is also known as Baughman syndrome.[8]
  • Trisomy 18 (Edwards syndrome): AFA may be seen in association with trisomy 18.[9]
  • Popliteal pterygium syndrome (PPS): Popliteal pterygium syndrome (PPS) is a rare autosomal dominant disorder, first described by Trelat in 1869. The clinical features of the syndrome are highly variable and show different combinations of anomalies like cleft palate, cleft lip, lower lip pits or sinuses, popliteal webbing, syndactyly, genitourinary anomalies, nail anomalies, syngnathia, ankyloblepharon, talipes, and digital reduction defects.[10]

Acquired ankyloblepharon

Acquired ankyloblepharon may occur due to trauma or inflammatory conditions. It may be associated with symblepharon also. The following conditions cause ankyloblepharon:[3]

Treatment

Lids should be separated by excision of adhesions between the lid margins and kept apart during the healing process. When adhesions extend to the angles, epithelial grafts should be given to prevent recurrences.[14]

History

Ankyloblepharon was first described by von Anmmon in 1841.[15] Ankyloblepharon filiforme adnatum (AFA), the interrupted form of Ankyloblepharon, was first described by Von Hasner in 1881.[3]

Etymology

The word ankyloblepharon is derived from Greek ankylos (ἀγκύλος) 'bent, crooked, closed' and blepharon (βλέφαρον) 'eyelid'.

See also

References
  1. Scott R. Lambert, Christopher J. Lyons. "Management of lid conditions". Taylor and Hoyt's Pediatric Ophthalmology and Strabismus (5 ed.). Elsevier. p. 176.
  2. "Ankyloblepharon Filiforme Adnatum: Report of Two Cases". {{cite journal}}: Cite journal requires |journal= (help)
  3. "Ankyloblepharon". National Health Portal, India.
  4. "Ankyloblepharon". Elements of Morphology. National Human Genome Research Institute. Retrieved 2022-10-29.
  5. Hall, Bryan D.; Graham, John M.; Cassidy, Suzanne B.; Opitz, John M. (January 2009). "Elements of morphology: standard terminology for the periorbital region". American Journal of Medical Genetics. Part A. 149A (1): 29–39. doi:10.1002/ajmg.a.32597. ISSN 1552-4833. PMID 19125427.
  6. Sunila Jain, Antony J Atkinson, Bryan Hopkisson (1997). "Ankyloblepharon filiforme adnatum". British Journal of Ophthalmology. 81 (8): 705d. doi:10.1136/bjo.81.8.705d. PMC 1722285. PMID 9349166.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. Sonal B Dudhia, Bhavin B Dudhia, Jigna S Shah. "Ankyloblepharon". American Academy of Ophthalmology.{{cite web}}: CS1 maint: multiple names: authors list (link)
  8. Sabin Sahu. "Hay-Wells syndrome: Report of a rare disorder with dental management". Journal of Indian Academy of Oral Medicine and Radiology.
  9. D I Clark and A Patterson (1985). "Ankyloblepharon filiforme adnatum in trisomy 18 (Edwards's syndrome)". British Journal of Ophthalmology. 69 (6): 471–473. doi:10.1136/bjo.69.6.471. PMC 1040633. PMID 4005216.
  10. Muhammad Qasim and Mahmood Shaukat (2012). "Popliteal Pterygium Syndrome: A Rare Entity". APSP Journal of Case Reports. 3 (1): 5. PMC 3418038. PMID 22953299.
  11. AK Khurana. "Diseases of conjunctiva". Comprehensive Ophthalmology (6 ed.). Jaypee. p. 70.
  12. AK Khurana. "Diseases of conjunctiva". Comprehensive Ophthalmology (6 ed.). Jaypee. p. 85.
  13. Schonberg, Stacy; Stokkermans, Thomas J. (2020). "Ocular Pemphigoid". StatPearls. StatPearls Publishing. PMID 30252356.
  14. AK Khurana. "Disorders of the eyelid". Comprehensive Ophthalmology (6 ed.). Jaypee. p. 378.
  15. "Congenital eyelid anomalies". Albert & Jakobiec's principles and practice of ophthalmology (3rd ed.). pp. 3219–3220. ISBN 9781416000167.
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