Avon Longitudinal Study of Parents and Children
The Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s and formerly the Avon Longitudinal Study of Pregnancy and Childhood, is a cohort study of children born in the former county of Avon, England during 1991 and 1992.[1] It is used by researchers in health, education and other social science disciplines.
 | |
| Established | 1991 |
|---|---|
| Director | George Davey Smith |
| Location | Bristol |
Operating agency | University of Bristol |
| Website | http://childrenofthe90s.ac.uk/ |
The study is hosted at the University of Bristol and was initially led by Jean Golding, then George Davey Smith.[2] Currently the Principal Investigator for the study is Prof Nic Timpson.
The initial recruits were 15,247 pregnant women with estimated dates of delivery between April 1991 and December 1992. Since then the fathers, siblings and children of the participants have also begun to be studied and the study has launched Children of the Children of the 90s[3] as a new generation is born.[1]
It is one of a family of similar studies that were set up at around the same time in six countries across Europe, known as the European Longitudinal Study of Pregnancy and Childhood (ELSPAC). ELSPAC included studies in Czechoslovakia[4] and the Isle of Man,[5] in addition to ALSPAC.
Liver disease
In the study, 2.5% of 4,000 people born in 1991 and 1992 were found by ultrasound scanning at the age of 18 to have non-alcoholic fatty liver disease; five years later transient elastography (fibroscan) found over 20% to have the fatty deposits on the liver of steatosis, indicating non-alcoholic fatty liver disease; half of those were classified as severe. The scans also found that 2.4% had the liver scarring of fibrosis, which can lead to cirrhosis.[6]
References
- http://www.bristol.ac.uk/alspac/ ALSPAC website, accessed 15 October 2014
- http://www.wellcome.ac.uk/Achievements-and-Impact/Initiatives/UK-biomedical-science/ALSPAC/index.htm Archived 2010-05-24 at the Wayback Machine Wellcome Trust page on ALSPAC, accessed 24 February 2010
- Lawlor, Deborah A.; Lewcock, Melanie; Rena-Jones, Louise; Rollings, Claire; Yip, Vikki; Smith, Daniel; Pearson, Rebecca M.; Johnson, Laura; Millard, Louise A. C. (20 February 2019). "The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile". Wellcome Open Research. 4: 36. doi:10.12688/wellcomeopenres.15087.1. ISSN 2398-502X. PMC 6971848. PMID 31984238.
- "About the ELSPAC study". ELSPAC. Retrieved 6 April 2015.
- "ELSPAC in the Isle of Man". University of Bristol. Retrieved 6 April 2015.
- Sarah Boseley (12 April 2019). "Experts warn of fatty liver disease 'epidemic' in young people". The Guardian.
Further reading
- Pearson, Helen (12 April 2012). "Children of the 90s: Coming of age". Nature. 484 (7393): 155–158. Bibcode:2012Natur.484..155P. doi:10.1038/484155a. PMID 22498607.
- Frood, Arran (26 May 2012). "Profile: Children of the 90s comes of age". The Lancet. 379 (9830): 1938. doi:10.1016/S0140-6736(12)60843-5. PMID 22645741. S2CID 3904090.
- Boyd, A.; Golding, J.; Macleod, J.; Lawlor, D. A.; Fraser, A.; Henderson, J.; Molloy, L.; Ness, A.; Ring, S.; Davey Smith, G. (16 April 2012). "Cohort Profile: The 'Children of the 90s'--the index offspring of the Avon Longitudinal Study of Parents and Children". International Journal of Epidemiology. 42 (1): 111–127. doi:10.1093/ije/dys064. PMC 3600618. PMID 22507743.
- Fraser, A.; Macdonald-Wallis, C.; Tilling, K.; Boyd, A.; Golding, J.; Davey Smith, G.; Henderson, J.; Macleod, J.; Molloy, L.; Ness, A.; Ring, S.; Nelson, S. M.; Lawlor, D. A. (16 April 2012). "Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort". International Journal of Epidemiology. 42 (1): 97–110. doi:10.1093/ije/dys066. PMC 3600619. PMID 22507742.
- History of Modern Biomedicine Research Group (2012). C Overy; L A Reynolds; E M Tansey (eds.). History of the Avon Longitudinal Study of Parents and Children (ALSPAC), c.1980–2000. Queen Mary, University of London. ISBN 978-090223-8787.