Basopenia

Basopenia (or basocytopenia) is a form of agranulocytosis associated with a deficiency of basophils.[1] It has been proposed as an indicator of ovulation.[2] It is difficult to detect without flow cytometry, because normal levels are so low.[3] It can be defined as less than 0.01 x 109 / L.[4]

Basopenia
SpecialtyHematology 

Associated conditions
  • Hereditary absence of basophils (very rare)
  • Elevated levels of glucocorticoids
  • Hyperthyroidism or treatment with thyroid hormones
  • Ovulation
  • Hypersensitivity reactions
  • Leukocytosis (in association with diverse disorders)

References
  1. "Definition: basophilic leukopenia from Online Medical Dictionary".
  2. Soni R, Bose S, Gada D, Potnis V (October 1996). "Basopenia as an indicator of ovulation (a short term clinical study)". Indian J. Physiol. Pharmacol. 40 (4): 385–8. PMID 9055113.
  3. "CLS_3223_Unit 03_WBC". Archived from the original on 2009-01-30.
  4. "Pathology".
  5. Lourenço FD, Azor MH, Santos JC (May 2008). "Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus". Br. J. Dermatol. 158 (5): 979–86. doi:10.1111/j.1365-2133.2008.08499.x. PMID 18341658. S2CID 2935740.
  6. Grattan CE, Dawn G, Gibbs S, Francis DM (March 2003). "Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity". Clin. Exp. Allergy. 33 (3): 337–41. doi:10.1046/j.1365-2222.2003.01589.x. PMID 12614448. S2CID 30477970.
  7. Grattan CE, Walpole D, Francis DM (December 1997). "Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activity". Clin. Exp. Allergy. 27 (12): 1417–24. doi:10.1111/j.1365-2222.1997.tb02986.x. PMID 9433937.


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