Adapalene/benzoyl peroxide

Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of severe acne vulgaris.[1][2] It consists of a combination of adapalene and benzoyl peroxide in a topical gel formulation.[1][2]

Adapalene/benzoyl peroxide
Combination of
AdapaleneRetinoid
Benzoyl peroxidePeroxide
Clinical data
Trade namesEpiduo, Epiduo Forte
Routes of
administration		Topical
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG
 NY (what is this?)  (verify)

Medical uses

Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.[1][2]

Side effects

Commonly reported side effects include the following:[1][2]

Research

Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.[3]

The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied;[4] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).

References
  1. "Epiduo- adapalene and benzoyl peroxide gel". DailyMed. 21 February 2018. Retrieved 15 May 2022.
  2. "Epiduo Forte- adapalene and benzoyl peroxide gel". DailyMed. 27 April 2022. Retrieved 15 May 2022.
  3. Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients". The Journal of Dermatological Treatment. 22 (4): 197–205. doi:10.3109/09546631003681094. PMID 20666678. S2CID 34631151.
  4. Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, et al. (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study". The British Journal of Dermatology. 165 (2): 383–90. doi:10.1111/j.1365-2133.2011.10374.x. PMID 21495995. S2CID 21793660.
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