Binding coefficient
In medicinal chemistry and pharmacology, a binding coefficient is a quantity representing the extent to which a chemical compound will bind to a macromolecule.[1][2] The preferential binding coefficient can be derived from the Kirkwood-Buff solution theory of solutions. Preferential binding is defined as a thermodynamic expression that describes the binding of the cosolvent over the solvent. This is in a system that is open to both the solvent and cosolvent. [3] Consequently, preferential interaction coefficients are measures of interactions that involve “solutes that participate in a reaction in solution.” [4]
See also
- Binding constant
- Partition coefficient
- Binding affinity
References
- Schurr JM, Rangel DP, Aragon SR. (2005) "A Contribution to the Theory of Preferential Interaction Coefficients." Archived October 11, 2007, at the Wayback Machine Biophysical Journal. 89:2258-2276.
- Shulgin IL, Ruckenstein E (2006) "A Protein Molecule in a Mixed Solvent: The Preferential Binding Parameter via the Kirkwood-Buff theory." Biophysical Journal. 90:704–707.
- Pierce V, Kang M, Weerasinghe S, Smith PE. (2008) "Recent Applications of Kirkwood-Buff Theory to Biological Systems." Cell Biochem Biophys. 50(1):1-22.
- Thomas Record Jr. M, Anderson CF. (1995) "Interpretation of Preferential Interaction Coefficients of Nonelectrolytes and of Electrolyte Ions in Terms of a Two-Domain Model." Biophysical Journal. 68:786-794.
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