CFU-GM

CFU-GM, also known as granulocyte–macrophage progenitor (GMP), is a colony forming unit. It is derived from CFU-GEMM.

CFU-GM
Lineage. Captions in Polish, but "GMP" visible near bottom center.
Details
Gives rise toMonoblasts and myeloblasts
LocationBone marrow
Functioncolony forming unit
Identifiers
MeSHD055014
THH2.00.04.3.02009
Anatomical terms of microanatomy

The "GM" stands for "granulocyte, monocyte".[1]

It is the precursor for monoblasts and myeloblasts.

Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).

Granulocytes

There is some controversy over which granulocytes derive from CFU-GM.

  • There is little disagreement that neutrophils come from CFU-GM.
  • Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos".[2]
  • Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".[3]

See also

References
  1. "Hem I WBC Morphology and Physiology". Archived from the original on December 25, 2008. Retrieved 2008-12-30.
  2. Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. p. 107. ISBN 0-07-144159-X.
  3. Rudolph, Colin David (2003). Rudolph's pediatrics. New York: McGraw-Hill, Medical Pub. Division. p. 1563. ISBN 0-8385-8285-0.
  • CFU-GM at the US National Library of Medicine Medical Subject Headings (MeSH)


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