Calcium carbimide

Calcium carbimide, sold as the citrate salt under the trade name Temposil, is a disulfiram-like medication. Its effects are similar to the medication disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.

Calcium carbimide
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • calcium 2-hydroxypropane-1,2,3-tricarboxylate; methylcyanamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC6H6O7.C2H4N2.Ca
3D model (JSmol)
SMILES
  • [Ca+2].O=C([O-])CC(O)(CC(=O)O)C([O-])=O.N#CNC
InChI
  • InChI=1S/C6H8O7.C2H4N2.Ca/c7-3(8)1-6(13,5(11)12)2-4(9)10;1-4-2-3;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);4H,1H3;/q;;+2/p-2 Y
  • Key:ZZOBQLACMMNMCT-UHFFFAOYSA-L Y
 NY (what is this?)  (verify)

A recent 9-year study found that incorporation of supervised carbimide and the similar medication, disulfiram, into a comprehensive treatment program resulted in an abstinence rate of over 50%.[1]

Temposil was developed by Drs. Ken Ferguson and Gordon Bell, who tested the medication on themselves.[2][3][4] It was patented in 1955 by the Alcoholism Research Foundation of Ontario.[5]

See also

References
  1. Krampe H, Stawicki S, Wagner T, et al. (January 2006). "Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcome". Alcoholism: Clinical and Experimental Research. 30 (1): 86–95. doi:10.1111/j.1530-0277.2006.00013.x. ISSN 0145-6008. PMID 16433735.
  2. "Ogspi "PLO" 2005 Obituary". Ontario Genealogical Society.
  3. "Deaths - Canadian Medical Association Journal". CMAJ. Canadian Medical Association Journal. 162 (8): 1259. 18 April 2000.
  4. "Pioneer in Addiction Treatment Dr. Robert Gordon Bell Leaves Behind a Legacy of Hope and Healing" (PDF). Ontario Federation of Community Mental Health and Addiction Programs. Archived from the original (PDF) on 2014-03-11.
  5. Booze: A Distilled History. Between The Lines. 2003. ISBN 9781896357836.
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