Center for Cerebrovascular Research

The Center for Cerebrovascular Research at the University of California, San Francisco is a collective of faculty and staff investigating matters related to cerebral circulation, particularly cerebrovascular disease resulting from narrowing of major blood vessels in the brain and vascular malformation of the brain.[1] [2] While research offices are located on Parnassus campus, San Francisco General Hospital hosts the center's laboratories and facilities. The center coordinates with additional faculty in various fields of neuroscience and vascular biology. Sponsors include the National Institute of Neurological Disorders and Stroke and the UCSF departments of Anesthesia, Neurological Surgery and Neurology.

History

The Center for Cerebrovascular Research was established at the University of California San Francisco in 2000.

Clinical trials

The CCR is a participating in the first attempt at studying brain arteriovenous malformation (BAVM) management using a randomized controlled clinical trial.[3][4] This multi-center trial (ARUBA: A Randomized Trial of Unruptured Brain Arteriovenous Malformations) has been funded by the National Institute of Neurological Disorders and Stroke (NINDS). The goal of the project is to test the null hypothesis that treatment, by means of interventional procedures, surgery, or radiotherapy offers no difference in the risk of death or symptomatic stroke, and no better functional outcome than does conservative management at five years from discovery of an unruptured brain arteriovenous malformation (BAVM).

Specific areas of research

Accolades

William L. Young, M.D., Recipient of the 2009 Excellence in Research Award[5] NIH Announces Expansion of Rare Diseases Clinical Research Network Nineteen New and Returning Consortia to be Awarded $117 Million[6]

References
  1. Berman MF, Sciacca RR, Pile-Spellman J, et al. (August 2000). "The epidemiology of brain arteriovenous malformations". Neurosurgery. 47 (2): 389–96, discussion 397. doi:10.1097/00006123-200008000-00023. PMID 10942012.
  2. Kim H, Sidney S, McCulloch CE, et al. (September 2007). "Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients". Stroke. 38 (9): 2430–7. doi:10.1161/STROKEAHA.107.485573. PMID 17673729.
  3. "A Randomized Trial of Unruptured Brain Arteriovenous Malformations". www.arubastudy.org. 12 November 2021.
  4. Clinical trial number NCT00389181 for "A Randomized Trial of Unruptured Brain AVMs (ARUBA)" at ClinicalTrials.gov
  5. "William L. Young, M.D., Recipient of the 2009 Excellence in... : Anesthesiology". Archived from the original on 2012-09-30. Retrieved 2009-10-26.
  6. "NIH Announces Expansion of Rare Diseases Clinical Research Network". 27 September 2015.
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