Dentin sialophosphoprotein

Dentin sialophosphoprotein is a precursor protein for other proteins found in the teeth. It is produced by cells (odontoblasts) inside the teeth (dental pulp), and in smaller quantities by bone tissues (osteoblasts and osteocytes). It is required for normal hardening (mineralisation) of teeth. During teeth development, it is broken down into three proteins such as dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP).[1] These proteins become the major non-collagenous components of teeth. Their distribution in the collagen matrix of the forming dentin suggests these proteins play an important role in the regulation of mineral deposition. Additional evidence for this correlation is phenotypically manifested in patients with mutant forms of dentin sialophosphoprotein. Such patients suffer dental anomalies including type III dentinogenesis imperfecta.[2][3]

Dentin sialophosphoprotein
Identifiers
SymbolDSPP
Alt. namesDentin Phosphophoryn
NCBI gene1834
HGNC3054
OMIM125485
UniProtQ9NZW4
Other data
LocusChr. 4 q22.1
Search for
StructuresSwiss-model
DomainsInterPro

It is coded by a gene of the same name (dentin sialophosphoprotein, or DSPP) present on human chromosome 4. This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene.[4]

References

  1. Yamamoto, R.; Oida, S.; Yamakoshi, Y. (2015). "Dentin Sialophosphoprotein–derived Proteins in the Dental Pulp". Journal of Dental Research. 94 (8): 1120–1127. doi:10.1177/0022034515585715. PMID 25951824. S2CID 24609252.
  2. Letty Moss-Salentijn, Biology of Mineralized Tissue coursenotes, Columbia University College of Dental Medicine, 2009
  3. Nanci, Antonio. Ten Cate's Oral Histology: Development, Structure, and Function. 7th ed. St. Louis, MO: Mosby Elsevier, 2008. Print.
  4. "Entrez Gene: DSPP dentin sialophosphoprotein".

Further reading

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