Ehrlichia ruminantium

Heartwater (also known as cowdriosis, nintas, and ehrlichiosis) is a tick-borne rickettsial disease.[2] The name is derived from the fact that fluid can collect around the heart or in the lungs of infected animals.[3] It is caused by Ehrlichia ruminantium (formerly Cowdria ruminantium) - an intracellular Gram-negative coccal bacterium (also referred to as Rickettsia ruminantium). The disease is spread by various Amblyomma ticks, and has a large economic impact on cattle production in affected areas. There are four documented manifestations of the disease, these are acute, peracute, subacute, and a mild form known as heartwater fever. There are reports of zoonotic infections of humans by E. ruminantium, similar to other Ehrlichia species, such as those that cause human ehrlichiosis.[4][5][6]

Heartwater
Oedematous pericardium of a goat that died of heartwater disease, caused by infection with Ehrlichia ruminantium, transmitted by Amblyomma ticks in Africa and Caribbean
Scientific classification
Domain:
Bacteria
Phylum:
Pseudomonadota
Class:
Alphaproteobacteria
Order:
Rickettsiales
Family:
Ehrlichiaceae
Genus:
Ehrlichia
Species:
E. ruminantium [1]
Binomial name
Ehrlichia ruminantium
(Dumler, 2001)
Synonyms
  • Cowdria ruminantium (Cowdry 1925) Moshkovski 1947 (Approved Lists 1980)

History

Heartwater disease was first described in 1838 within the personal journal of Louis Trichardt, a Voortrekker in South Africa. In Trichardt's notes he recorded that a majority of the surrounding sheep died approximately three weeks after a large tick infestation was observed.[7]

In an 1877 testimony to the Cape of Good Hope Commission on Diseases of Sheep and Goats livestock producer J Webb testified that the appearance of ticks on his farm 8 or 9 years earlier corresponded with an onset of fatal disease in his livestock. Webb reported opening the chest of the victims and discovering the "heart bag" to be full of "water."

Heartwater first reached the Caribbean islands in 1980.[3]

Distribution

The disease is common in sub-Saharan Africa, but can ultimately be found wherever Amblyomma ticks are present. Major areas of concern for the disease also include Madagascar, Mauritius, Zanzibar, the Comoros Islands, and Sao Tomé. Heartwater has been observed on three of the Caribbean islands, Guadeloupe, Marie-Galante, and Antigua.

In the Caribbean, at least, the cattle egret has been implicated in the spread of heartwater, since it colonized the islands in the 1950s.[3]

Hosts

Nearly all members of Bovidae are susceptible to this disease, but vary in their susceptibility, Zubu and Water buffalo appearing to be most resistant.[8] The most susceptible species to heartwater appears to be the various goats.[9][10][11] The South African buffalo, bleskbok, black wildebeest, helmeted guinea fowl, leopard tortoise and scrub hare are known to host heartwater without symptoms and act as a tick reservoir.[12]

Experimental hosts

In laboratory experiments non-ruminants such as ferrets, laboratory mice, and four-striped grass mice have demonstrated susceptibility to the disease.

Clinical signs

Clinical disease is more common in young animals and non-native breeds. The clinical signs of disease are caused by an increased vascular permeability and consequent oedema and hypovolemia.

The symptoms include neurological signs such as tremors and head pressing, respiratory signs such as coughing and nasal discharge, and systemic signs such as fever and loss of appetite. Physical examination may reveal petechiae of the mucous membranes, tachycardia, and muffled heart sounds. Heartwater can also cause reproductive and gastrointestinal disease. It is frequently fatal.

Diagnosis
Ehrlichia ruminantium bacteria within the brain of sheep that died in Africa

On post mortem examination, a light yellow transudate that coagulates on exposure to air is often found within the thorax, pericardium, and abdomen. Most fatal cases have the hydropericardium that gives the disease its common name. Pulmonary oedema and mucosal congestion are regularly seen along with frothy fluid in the airways and cut surfaces of the lungs. To definitively diagnose the disease, C. ruminantium must be demonstrated either in preparations of the hippocampus under Giemsa staining or by histopathology of brain or kidney.

Treatment and control

During the early stages of disease, animals may be treated with sulfonamides and tetracyclines.[13][14] In advanced disease, prognosis is poor. Tetracyclines can also be used prophylactically when animals are introduced into an area endemic with heartwater. Ectoparasiticides, used as dips, can be used to reduce exposure the animals exposure to bont ticks. In areas endemic for heartwater, the use of dips against other ticks of domestic animals, such as Rhipicephalus (Boophilus) and Hyalomma species is likely, and this will usually contribute to control of vectors of E. ruminantium.

Vaccines

A live blood vaccine is available for protection of young stock, but animals may require treatment for the disease after vaccination. Several experimental vaccines are currently being developed, examples include attenuated, recombinant and multi-epitope DNA vaccines.[9][15]

Mortality

Depending on the species of the animal the mortality rate of the disease may vary from 5% to 90%. Mortality rates appear to be the highest within the various sheep and goat species, but this is not always the case, as some sheep species such as the Afrikaner have mortality rates only reaching as high as 6%.[16]

Global status

Heartwater is notifiable to the World Organization for Animal Health.

United States

The U.S. Department of Agriculture believes that an outbreak in the U.S could cost the livestock industry up to $762 million in losses annually. The tick that carries the disease is thought to be capable of being transported by migratory birds from the Caribbean to at least Florida. The U.S has prepared an in-depth response plan to mitigate damages and contain any detected spread.[17]

See also

References
  1. Dumler JS, Barbet AF, Bekker CP, Dasch GA, Palmer GH, Ray SC, et al. (November 2001). "Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila". International Journal of Systematic and Evolutionary Microbiology. 51 (Pt 6): 2145–2165. doi:10.1099/00207713-51-6-2145. PMID 11760958.
  2. Peter TF, Burridge MJ, Mahan SM (May 2002). "Ehrlichia ruminantium infection (heartwater) in wild animals". Trends in Parasitology. 18 (5): 214–8. doi:10.1016/s1471-4922(02)02251-1. PMID 11983602.
  3. "Heartwater". Animal and Plant Health Inspection Service. U.S. Department of Agriculture. Archived from the original on 2008-04-13. Retrieved 2008-04-13.
  4. Allsopp MT, Louw M, Meyer EC (December 2005). "Ehrlichia ruminantium: an emerging human pathogen?". Annals of the New York Academy of Sciences. 1063 (1): 358–60. Bibcode:2005NYASA1063..358A. doi:10.1196/annals.1355.060. PMID 16481543. S2CID 35037984.
  5. Gaddy HG (August 2020). "Using local knowledge in emerging infectious disease research". Social Science & Medicine. 258: 113107. doi:10.1016/j.socscimed.2020.113107. PMC 7292947. PMID 32563166.
  6. Esemu SN, Ndip LM, Ndip RN (2011-01-01). "Ehrlichia species, probable emerging human pathogens in sub-Saharan Africa: environmental exacerbation". Reviews on Environmental Health. 26 (4): 269–79. doi:10.1515/REVEH.2011.034. PMID 22435325. S2CID 26448157.
  7. "Heartwater in Sheep and Goats". The Veterinary Journal (1900). 55 (9): 157–161. 1902. doi:10.1016/s0372-5545(17)72105-0. ISSN 0372-5545.
  8. Pfukenyi, Davies M.; Mukaratirwa, Samson (2018-10-18). "Amphistome infections in domestic and wild ruminants in East and Southern Africa: A review". Onderstepoort Journal of Veterinary Research. 85 (1): e1–e13. doi:10.4102/ojvr.v85i1.1584. ISSN 2219-0635. PMC 6244199. PMID 30456960.
  9. Zweygarth, Erich; Josemans, Antoinette I.; Steyn, Helena C. (2008). "Experimental use of the attenuated Ehrlichia ruminantium (Welgevonden) vaccine in Merino sheep and Angora goats". Vaccine. 26: G34–G39. doi:10.1016/j.vaccine.2008.09.068. PMID 19178891.
  10. Leask, Rhoda; Pettey, Kenneth P.; Bath, Gareth F. (2013-10-23). "An afebrile heartwater-like syndrome in goats". Journal of the South African Veterinary Association. 84 (1). doi:10.4102/jsava.v84i1.955. ISSN 2224-9435.
  11. Ahmadu, B.; Lovelace, C.E.A.; Mahan, S. (2004-11-08). "Some observations on the sero-prevalence of heartwater and tick infestation in Zambian goats : research communication". Onderstepoort J Vet Res. 71 (2): 161–164. doi:10.4102/ojvr.v71i2.279. ISSN 2219-0635. PMID 15373339.
  12. "Tick Biolgy and Control. ed. G.B. Whitehead and J.D. Gibson. 222 pages. Proceedings of an International Conference held in January 1981 under the auspices of the Tick Research Unit, Rhodes University, Grahamstown, South Africa. ISBN 0 86810 047 1. Tick Research Unit, Rhodes University, Grahamstown, South Africa, 1982". Parasitology. 85 (3): 616. 1982. doi:10.1017/s0031182000056420. ISSN 0031-1820.
  13. Purnell, R. E.; Gunter, T. D.; Schroder, J. (1989). "Development of a prophylactic regime using long-acting tetracycline for the control of redwater and heartwater in susceptible cattle moved into an endemic area". Tropical Animal Health and Production. 21 (1): 11–19. doi:10.1007/BF02297335. ISSN 0049-4747. PMID 2711456. S2CID 26042627.
  14. Karrar, Gaafar; El Hag Ali, Babiker (1965-01-01). "Oral Treatment of Heartwater With Oxytetracycline (Terramycin Soluble Powder)". British Veterinary Journal. 121 (1): 28–33. doi:10.1016/S0007-1935(17)41404-7. ISSN 0007-1935. PMID 14267728.
  15. COLLINS, NICOLA E.; PRETORIUS, ALRI; KLEEF, MIRINDA; BRAYTON, KELLY A.; ZWEYGARTH, ERICH; ALLSOPP, BASIL A. (2003). "Development of Improved Vaccines for Heartwater". Annals of the New York Academy of Sciences. 990 (1): 474–484. Bibcode:2003NYASA.990..474C. doi:10.1111/j.1749-6632.2003.tb07413.x. ISSN 0077-8923. PMID 12860676. S2CID 26038896.
  16. Deem, Sharon L. (1996). "Heartwater (cowdriosis): A review, 2nd edn". Parasitology Today. 12 (8): 328. doi:10.1016/0169-4758(96)80823-4. ISSN 0169-4758.
  17. "Heartwater - Emerging Pathogens Institute - University of Florida". www.epi.ufl.edu. Retrieved 2022-07-11.

Additional references
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