Epidural blood patch

EBPs are administered for treatment-related or spontaneous orthostatic headaches.[1] The procedure is most often used to relieve PDPH following an epidural injection and lumbar puncture. Most PDPHs are self-limiting, so epidural blood patches are only used for people with moderate to severe cases who do not respond to conservative treatment.[2][3] It is also used to treat spontaneous intracranial hypotension (SIH).[4][3] EBP has been used to treat pseudomeningoceles and leaks around intrathecal pumps.[5] For SIH, the same administration technique is used but at a different location with a different amount of blood injected.[6]

EBPs are contraindicated in people with bleeding disorders, infection at the puncture site, fever, and bloodstream infections or sepsis.[3] Some recommend blood culture before administration.[13] EBPs should not be administered if there is a systemic infection. It may be contraindicated in people with a spinal deformity, HIV/AIDS, and leukemia. Epidurals are recommended for perioperative COVID-19 people over general anesthesia—EBPs have an extremely low risk of transferring an infection to the central nervous system even with an ongoing infection but are a last resort after conservative treatments and nerve blocks.[3] People who have malignancies as a result of cancer may be contraindicated though it is not an absolute contraindication; though little large-scale clinical studies have been conducted, no adverse effects have been reported.[9]

EBPs are invasive[13] but are highly effective with a 50-80% success rate, and are relatively low risk, except the risks associated with epidural administration.[2][8] Waiting 24 hours before administration reduces the failure rate of it significantly,[13] though performing it within 48 hours after puncture is associated with a higher need for repeat patches.[8] Successful treatment of PDPH with EBP has been reported months after onset.[5] Success rates may be higher than 96% with repeated EBP, even in the pediatric population.[9] EBPs are more likely to be successful with more than 22.5 mL of blood injected, and in people with less severe spinal CSF leakage. In people with severe leakage, treatment outcome does not depend on the amount of blood injected.[14] An ineffective EBP is more likely to occur in people with SIH where the CSF leak was not identified—they may be repeated for these people. Nerve compression can also occur which can result in transient neurologic damage; less frequently, this may be permanent.[6] Some people may benefit from fibrin glue mixed with the blood.[15] EBP may cause more side effects than a topical nerve block of the sphenopalatine neuron cell group in postpartum people though no large-scale clinical trials have been conducted.[16] Multiple EBPs can be administered as necessary; this is more likely to happen with people with spontaneous headache or multiple leakages.[1] About 20% of people need a second EBP, and up to 20% of women do not have their symptoms resolved.[8]

Additional dural puncture can occur, however, which may increase the chance of inadvertently injecting blood intrathecally.[3] Prophylactic EBPs do not decrease the risk of getting PDPH.[2] The use of EBPs as a treatment for PDPH, although historically considered aggressive, is increasing in adolescents as they are less likely to have their headaches resolved by conservative treatment.[9] Fluoroscopic EBPs are more successful than blindly administered ones. The failure rate is around 15-20%,[3] though this can get as high as 30%.[13] Common side effects are headache, back pain, neck pain, and mild fever. Back pain is reported in approximately 80% of people, which might be a result of increased pressure. Radicular pain may also occur.[3] Rebound intracranial hypotension is very common in people with SIH after an EBP, and can be treated with acetazolamide, topiramate, or in severe cases therapeutic lumbar puncture; most cases are not severe. Rare side effects include subdural or spinal bleeding, infection, and seizure,[3] though EBPs do not carry a significant infectious risk even in immunocompromised people.[5] Neurological symptoms occasionally develop as a result of administration.[8] Seven cases of arachnoiditis have been documented.[17]

The treatment of PDPH was historically uncertain—49 recommendations existed for the treatment of it. It was originally thought to be more of a psychogenic disease, which may have delayed the development of EBPs. Turan Ozdil, an anesthesiology instructor at the University of Tennessee, hypothesized how clotted blood could plug a hole in the dura while observing a car tire repair.[5] He worked with his associate W. Forrest Powell, leading to trials on dog models and then on humans around 1960.[5] James B. Gormley, a general surgeon, first observed how bloody lumbar punctures led to reduced rates of PDPH also in 1960;[3] Gormley would use only 2 to 3 mL of blood for experimenting with EBP, and he was not trained in epidural administration. Ozdil was unaware of Gormley's work, and Ozdil designed his technique to be prophylactic. Anesthesiologist Anthony DiGiovanni refined Ozdil and Powell's technique, using 10 mL of blood to treat a person with unknown leakage locations. DiGiovanni's staff member Burdett Dunbar wanted to more widely disseminate their technique, though their study was initially rejected by Anesthesiology until publication in Anesthesia & Analgesia in 1970. Detractors such as Charles Bagley at Johns Hopkins University provided evidence against the treatment since 1928 as according to their studies blood in the CSF had significant side effects up to "severe convulsive seizures"; DiGiovanni disproved this in 1972.[5] J. Selwyn Crawford discovered in 1980 that using a larger volume of blood was more successful.[3] The procedure would be widely accepted at the end of the 1970s.[5]