Helicobacter hepaticus

Helicobacter hepaticus is a bacterium in the Helicobacteraceae family, Campylobacterales order.[1]

Helicobacter hepaticus
Scientific classification
Domain: Bacteria
Phylum: Campylobacterota
Class: "Campylobacteria"
Order: Campylobacterales
Family: Helicobacteraceae
Genus: Helicobacter
Species:
H. hepaticus
Binomial name
Helicobacter hepaticus
Fox et al., 1994

It has a spiral shape and bipolar, single, sheathed flagellum, and was first isolated from the livers of mice with active, chronic hepatitis. The bacteria also colonized the cecal and colonic mucosae of mice. It elicits persistent hepatitis in mice. It has also been associated with colorectal cancer and other diseases.[2][3] Its genome has been sequenced and is 1,799,146 bases long with 1,875 coding sequences.[4]

References

  1. Fox JG, Dewhirst FE, Tully JG, et al. (May 1994). "Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice". Journal of Clinical Microbiology. 32 (5): 1238–45. doi:10.1128/JCM.32.5.1238-1245.1994. PMC 263656. PMID 8051250.
  2. Fox, J G; Ge, Z; Whary, M T; Erdman, S E; Horwitz, B H (2010). "Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer" (PDF). Mucosal Immunology. 4 (1): 22–30. doi:10.1038/mi.2010.61. ISSN 1933-0219. PMC 3939708. PMID 20944559.
  3. Shames B, Fox JG, Dewhirst F, Yan L, Shen Z, Taylor NS (November 1995). "Identification of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay". Journal of Clinical Microbiology. 33 (11): 2968–72. doi:10.1128/JCM.33.11.2968-2972.1995. PMC 228616. PMID 8576355.
  4. Suerbaum, Sebastian (2003). "The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus". PNAS. 100 (13): 7901–7906. Bibcode:2003PNAS..100.7901S. doi:10.1073/pnas.1332093100. PMC 164685. PMID 12810954.

Further reading


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