Kussmaul's sign

Kussmaul's sign is a paradoxical rise in jugular venous pressure (JVP) on inspiration, or a failure in the appropriate fall of the JVP with inspiration. It can be seen in some forms of heart disease and is usually indicative of limited right ventricular filling due to right heart dysfunction.

Not to be confused with Kussmaul breathing.
Kussmaul's sign
SpecialtyCardiology

Pathophysiology

Ordinarily the JVP falls with inspiration due to reduced pressure in the expanding thoracic cavity and the increased volume afforded to right ventricular expansion during diastole. Kussmaul sign suggests impaired filling of the right ventricle due to a poorly compliant myocardium or pericardium. This impaired filling causes the increased blood flow to back up into the venous system, causing the jugular vein distension (JVD) and is seen clinically in the internal jugular veins becoming more readily visible.

Causes

The differential diagnoses of Kussmaul's sign includes constrictive pericarditis, restrictive cardiomyopathy, pericardial effusion, and severe right-sided heart failure.

With cardiac tamponade, jugular veins are distended and typically show a prominent x descent and an absent y descent as opposed to patients with constrictive pericarditis (prominent x and y descent), see Beck's triad.[1]

Other possible causes of Kussmaul's sign include:

History

Kussmaul's sign is named after the German doctor who first described it, Adolph Kussmaul (1822-1902).[3][4] He is also credited with describing Kussmaul breathing.[5]

See also

References
  1. Disorders of the Cardiovascular System; Harrison's Principles of Internal Medicine 17th, and Self-assessment & Board Review cardiovascular system questions 15, 29
  2. Meyer, Theo E.; Sareli, Pinhas; Marcus, Richard H.; Pocock, Wendy; Berk, Martin R.; McGregor, Maurice (1989). "Mechanism underlying Kussmaul's sign in chronic constrictive pericarditis". The American Journal of Cardiology. 64 (16): 1069–1072. doi:10.1016/0002-9149(89)90817-5. ISSN 0002-9149. PMID 2816746.
  3. synd/1368 at Who Named It?
  4. A. Kussmaul. Über schwielige Mediastino-Perikarditis und den paradoxen Puls. Berliner klinische Wochenschrift, 1873, 10: 433-435, 445-449 and 461-464.
  5. Kussmaul's respiration at Who Named It?
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