Lucimycin

Lucimycin (INN, also known as lucensomycin and etruscomycin) is a macrolide antibiotic synthesized by the bacterium Streptomyces lucensis. It belongs to the group of polyene antimycotics and was first isolated in the 1960s. It has seen only limited clinical use.

Lucimycin
Identifiers
CAS Number
3D model (JSmol)
ECHA InfoCard 100.032.667
PubChem CID
UNII
SMILES
  • CCCCC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O
Properties
Chemical formula
 C36H53NO13
Molar mass 707.80492
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Lucimycin is also produced by the Streptomyces cyanogenus S136, where the full biosynthetic gene cluster for the production of this compound was described.[1]

References
  1. Yushchuk O, Ostash I, Mösker E, Vlasiuk I, Deneka M, Rückert C, et al. (February 2021). "Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA". Scientific Reports. 11 (1): 3507. doi:10.1038/s41598-021-82934-6. PMC 7875965. PMID 33568768.

Further reading


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