Bone sarcoma

Favoured sites for the development of an osteosarcoma.

An osteosarcoma is predominantly found in childhood and adolescence.[1] They are primarily found in long bones, and may be secondary tumours.[3] Osteosarcomas are composed of mesenchymal cells that produce immature bone.[4] The tumour cells are unique in that they produce immature osteoid.[3]

Ewing's sarcoma is the next most commonly found sarcoma in adolescents and young adults. Ewing's is highly aggressive, typically developing from the medullary cavity of a bone with cells invading the Haversian system.[5] An immunohistochemistry test shows the tumour as having small rounded blue cells.[6][7] The cells express high levels of CD99.[5]

A chondrosarcoma is the type of bone cancer that starts in the cartilage cells. It is the most common type found in adults. Unlike the other types it is rarely found in those under the age of twenty. Most chondrosarcomas develop in the pelvis, legs or arms. Benign counterparts are known as enchondromas. Chondrosarcomas are classified by grade as a measurement of their growth rate – I, II, and III. The lower the grade the slower the rate of growth. Grade III are the most aggressive, and are liable to spread.[8]

Subtypes of chondrosarcomas have different features and different outlooks, they include:

Dedifferentiated

Dedifferentiated chondrosarcomas can change in part to cells that are like those of an osteosarcoma for example which has a faster rate of growth.

Clear cell

Clear cell chondrosarcomas are rare, slow-growing, and seldom spread.

Mesenchymal

Mesenchymal chondrosarcomas can grow quickly but unlike other types may respond to radiotherapy, and chemotherapy.[8] They have densely packed small round blue cells like those in Ewing's sarcoma.[9] Type II collagen can help distinguish it from other tumours.[10]