Nutritional genomics

Nutritional genomics, also known as nutrigenomics, is a science studying the relationship between human genome, human nutrition and health. People in the field work toward developing an understanding of how the whole body responds to a food via systems biology, as well as single gene/single food compound relationships.[1][2] Nutritional genomics or Nutrigenomics is the relation between food and inherited genes, it was first expressed in 2001.

[3]

Introduction

The term "nutritional genomics" is an umbrella term including several subcategories, such as nutrigenetics, nutrigenomics, and nutritional epigenetics. Each of these subcategories explain some aspect of how genes react to nutrients and express specific phenotypes, like disease risk.[4] There are several applications for nutritional genomics, for example how much nutritional intervention and therapy can successfully be used for disease prevention and treatment.[4]

Background and preventive health

Nutritional science originally emerged as a field that studied individuals lacking certain nutrients and the subsequent effects,[1] such as the disease scurvy which results from a lack of vitamin C. As other diseases closely related to diet (but not deficiency), such as obesity, became more prevalent, nutritional science expanded to cover these topics as well.[1] Nutritional research typically focuses on preventative measure, trying to identify what nutrients or foods will raise or lower risks of diseases and damage to the human body.

For example, Prader–Willi syndrome, a disease whose most distinguishing factor is insatiable appetite, has been specifically linked to an epigenetic pattern in which the paternal copy in the chromosomal region is erroneously deleted, and the maternal loci is inactivated by over methylation.[5] Yet, although certain disorders may be linked to certain single-nucleotide polymorphisms (SNPs) or other localized patterns, variation within a population may yield many more polymorphisms.[6]

Applications

The applications of nutritional genomics are multiple. With personalized assessment some disorders (diabetes, metabolic syndrome) can be identified. Nutrigenomics can help with personalized health and nutrition intake by assessing individuals and make specific nutritional requirements.[7] The focus is in the prevention and the correction of specific genetic disorders. Examples of genetic related disorders that improve with nutritional correction are obesity, coronary heart disease (CHD), hypertension and diabetes mellitus type 1.[8] Genetic disorders that can often be prevented by proper nutritional intake of parents include spina bifida, alcoholism and phenylketouria.

Coronary heart disease

Genes tied to nutrition manifest themselves through the body's sensitivity to food. In studies about CHD, there is a relationship between the disease and the presence of two alleles found at E and B apolipoprotein loci.[9] These loci differences result in individualized reactions to the consumption of lipids. Some people experience increased weight gain and greater risk of CHD whereas others with different loci do not. Research has shown a direct correlation between the decrease risk of CHD and the decrease consumption of lipids across all populations.[10]

Obesity

Obesity is one of the most widely studied topics in nutritional genomics. Due to genetic variations among individuals, each person could respond to diet differently. By exploring the interaction between dietary pattern and genetic factors, the field aims to suggest dietary changes that could prevent or reduce obesity.[11]

There appear to be some SNPs that make it more likely that a person will gain weight from a high fat diet; for people with AA genotype in the FTO gene showed a higher BMI compared those with TT genotype when having high fat or low carbohydrate dietary intake.[11] The APO B SNP rs512535 is another diet-related variation; the A/G heterozygous genotype was found to have association with obesity (in terms of BMI and waist circumference) and for individuals with habitual high fat diet (>35% of energy intake), while individuals with GG homozygous genotype are likely to have a higher BMI compared to AA allele carriers. However, this difference is not found in low fat consuming group (<35% of energy intake).[11]

Phenylketonuria

Phenylketonuria, otherwise known as PKU, is an uncommon autosomal recessive metabolic disorder that takes effect postpartum but the debilitating symptoms can be reversed with nutritional intervention.[4]

See also

References
  1. Neeha, V. S.; Kinth, P. (2013). "Nutrigenomics research: a review". Journal of Food Science and Technology. 50 (3): 415–428. doi:10.1007/s13197-012-0775-z. PMC 3602567. PMID 24425937.
  2. Fenech, Michael; El-Sohemy, Ahmed; Cahill, Leah; Ferguson, Lynnette R.; French, Tapaeru-Ariki C.; Tai, E. Shyong; Milner, John; Koh, Woon-Puay; Xie, Lin; Zucker, Michelle; Buckley, Michael; Cosgrove, Leah; Lockett, Trevor; Fung, Kim Y.C.; Head, Richard (2011). "Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice". Journal of Nutrigenetics and Nutrigenomics. 4 (2): 69–89. doi:10.1159/000327772. ISSN 1661-6758. PMC 3121546. PMID 21625170.
  3. Peregrin, Tony (2001). "The new frontier of nutrition science: Nutrigenomics". Journal of the American Dietetic Association. 101 (11): 1306. doi:10.1016/S0002-8223(01)00309-1. PMID 11716306.
  4. Camp, Kathryn M.; Trujillo, Elaine (February 2014). "Position of the Academy of Nutrition and Dietetics: Nutritional Genomics". Journal of the Academy of Nutrition and Dietetics. 114 (2): 299–312. doi:10.1016/j.jand.2013.12.001. ISSN 2212-2672. PMID 24439821.
  5. Xia, Q; Grant, SF (2013). "The genetics of human obesity". Ann N Y Acad Sci. 1281: 178–90. doi:10.1111/nyas.12020. PMC 3717174. PMID 23360386.
  6. Bisen, Prakash A.; Debnath, Mousumi; Prasad, Godavarthi B.K.S. (2010). Molecular Dianostics: Promises and Possibilities. Springer Science & Business Media. p. 26.ISBN 9048132614.
  7. Cameron, Louise (9 November 2016). "Nutrigenomics - looking at the individual within their nutritional environment".
  8. Information (US), National Center for Biotechnology (1998). Nutritional and Metabolic Diseases. National Center for Biotechnology Information (US).
  9. Health, National Research Council (US) Committee on Diet and (1989). Genetics and Nutrition. National Academies Press (US).
  10. DeBruyne, Linda K. (8 January 2015). Nutrition & diet therapy. Pinna, Kathryn,, Whitney, Ellie (Ninth ed.). Australia. ISBN 978-1-305-11040-3. OCLC 910704712.
  11. Doo, Miae; Kim, Yangha (2015-03-01). "Obesity: interactions of genome and nutrients intake". Preventive Nutrition and Food Science. 20 (1): 1–7. doi:10.3746/pnf.2015.20.1.1. ISSN 2287-1098. PMC 4391534. PMID 25866743.
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