Prolactin-releasing peptide receptor

The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.

PRLHR
Identifiers
AliasesPRLHR, GPR10, GR3, PrRPR, prolactin releasing hormone receptor
External IDsOMIM: 600895 MGI: 2135956 HomoloGene: 3134 GeneCards: PRLHR
Orthologs
SpeciesHumanMouse
Entrez

2834

226278

Ensembl

ENSG00000119973

ENSMUSG00000045052

UniProt

P49683

Q6VMN6

RefSeq (mRNA)

NM_004248

NM_201615

RefSeq (protein)

NP_004239

NP_963909

Location (UCSC)Chr 10: 118.59 – 118.6 MbChr 19: 60.46 – 60.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PrRPR is a G-protein coupled receptor[5] that binds the prolactin-releasing peptide (PRLH).[6]

Function

PrRPR is a 7-transmembrane domain receptor for prolactin-releasing peptide that is highly expressed in the anterior pituitary.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000119973 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000045052 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics. 29 (2): 335–44. doi:10.1006/geno.1995.9996. PMID 8666380.
  6. Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). "A prolactin-releasing peptide in the brain". Nature. 393 (6682): 272–6. Bibcode:1998Natur.393..272H. doi:10.1038/30515. PMID 9607765. S2CID 4306854.
  7. "Entrez Gene: PRLHR prolactin releasing hormone receptor".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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