Russell bodies

Russell bodies are inclusion bodies usually found in atypical plasma cells that become known as Mott cells.[1] Russell bodies are eosinophilic, homogeneous immunoglobulin (Ig)-containing inclusions usually found in cells undergoing excessive synthesis of Ig; the Russell body is characteristic of the distended endoplasmic reticulum. Russell bodies are large and globular of varying size, and become packed into the cell's cytoplasm pushing the nucleus to the edge of the cell, and are found in the peripheral areas of tumors. Russell bodies are thought to have originated as abnormal proteins that have not been secreted. The excess immunoglobulin builds up and forms intracytoplasmic globules, which is thought to be a result of insufficient protein transport within the cell. This causes the proteins to neither be degraded or secreted and stay stored in dilated cisternae.[2] In 1949, Pearse discovered that Russell bodies also contain mucoproteins that are secreted by plasma cells. Russell bodies are not tissue specific; during research they were induced in rat glioma cells.[3] Russell bodies were found to have positive reactions to PAS stain, CD 38 and CD 138 stains. Plasma cells that contain Russell bodies and are stained with H&E stain are found to be autofluorescent, while those without Russell bodies are not. Russell bodies tend to be found in places with chronic inflammation.

Mott cells with Russell bodies (red arrows), compared to an almost normal plasma cell (white arrow; it has a prominent nucleolus).
Plasmacytoma with abundant Russell bodies. H&E stain.
Dutcher and Russell bodies. H&E stain.

This is one cell variation found in multiple myeloma.[4]

Similar inclusion bodies that tend to overlie the nucleus or invaginate into it are known as Dutcher bodies.[5]

They are named for William Russell (1852-1940), a Scottish physician.[6][7]

Additional images
  • Russell bodies.

References
  1. Fellows, IW; Leach, IH; Smith, PG; Toghill, PJ; Doran, J (June 1990). "Carcinoid tumour of the common bile duct--a novel complication of von Hippel-Lindau syndrome". Gut. 31 (6): 728–9. doi:10.1136/gut.31.6.728. PMC 1378509. PMID 2379881.
  2. Rubio, C.A. (2005). "Mott Cell (Russell Bodies) Barrett's Oesophagitis" (PDF). In Vivo.
  3. Valetti, C., Grossi, C.E., Milstein, C., Sitia, R. (November 15, 1991). "Russell Bodies: A General Response of Secretory Cells to Synthesis of a Mutant Immunoglobulin Which Can Neither Exit from, Nor Be Degraded in, the Endoplasmic Reticulum". The Journal of Cell Biology. 115 (4): 983–994. doi:10.1083/jcb.115.4.983. PMC 2289943. PMID 1955467.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. Martín-Noya A, Ríos-Herranz E, Rafel-Ribas E (February 1999). "Multiple myeloma with numerous intranuclear Russell bodies". Haematologica. 84 (2): 179–80. PMID 10091418.
  5. "Dutcher Body in Recurrent Lymphoplasmacytic Lymphoma". imagebank.hematology.org. Retrieved 8 May 2021.
  6. synd/1962 at Who Named It?
  7. Russell, W. (1890). "An Address on a Characteristic Organism of Cancer". BMJ. 2 (1563): 1356–1360. doi:10.1136/bmj.2.1563.1356. PMC 2208600. PMID 20753194.


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