Sweat allergy

A sweat allergy is the exacerbation of atopic dermatitis associated with an elevated body temperature and resulting increases in the production of sweat. It appears as small reddish welts that become visible in response to increased temperature and resulting production of sweat.[1] It can affect all ages. Sweating can trigger intense itching or cholinergic urticaria. The protein MGL_1304 secreted by mycobiota (fungi) present on the skin such as Malassezia globosa acts as a histamine or antigen. People can be desensitized using their own samples of sweat that have been purified that contains small amounts of the allergen.[2][3] The allergy is not due to the sweat itself but instead to an allergy-producing protein secreted by bacteria found on the skin.[4]

Cholinergic urticaria (CU) is one of the physical urticaria (hives) which is provoked during sweating events such as exercise, bathing, staying in a heated environment, or emotional stress. The hives produced are typically smaller than classic hives and are generally shorter-lasting.[5][6]

Multiple subtypes have been elucidated, each of which require distinct treatment.[7][8]

Tannic acid has been found to suppress the allergic response, along with showering.[2]

See also

References
  1. Kan T, Hiragun T, Ishii K, Hiragun M, Yanase Y, Tanaka A, Hide M (July 2015). "Evaluation of recombinant MGL_1304 produced by Pichia pastoris for clinical application to sweat allergy". Allergology International. 64 (3): 266–271. doi:10.1016/j.alit.2015.03.003. PMID 26117259.
  2. Hiragun T, Hiragun M, Ishii K, Kan T, Hide M (July 2017). "Sweat allergy: Extrinsic or intrinsic?". Journal of Dermatological Science. 87 (1): 3–9. doi:10.1016/j.jdermsci.2017.03.002. PMID 28416076.
  3. Hiragun T, Hide M (2016). "Sweat Allergy". Current Problems in Dermatology. Karger Publishers. 51: 101–108. doi:10.1159/000446788. ISBN 978-3-318-05904-5. PMID 27584969.
  4. Yokozeki H (2016). Perspiration research. Basel New York: Karger. p. 52. ISBN 9783318059052.
  5. Moore-Robinson M, Warin RP (December 1968). "Some clinical aspects of cholinergic urticaria". The British Journal of Dermatology. 80 (12): 794–799. doi:10.1111/j.1365-2133.1968.tb11948.x. PMID 5706797.
  6. Hirschmann JV, Lawlor F, English JS, Louback JB, Winkelmann RK, Greaves MW (April 1987). "Cholinergic urticaria. A clinical and histologic study". Archives of Dermatology. 123 (4): 462–467. doi:10.1001/archderm.1987.01660280064024. PMID 3827277.
  7. Nakamizo S, Egawa G, Miyachi Y, Kabashima K (January 2012). "Cholinergic urticaria: pathogenesis-based categorization and its treatment options". Journal of the European Academy of Dermatology and Venereology. 26 (1): 114–116. doi:10.1111/j.1468-3083.2011.04017.x. PMID 21371134.
  8. Bito T, Sawada Y, Tokura Y (December 2012). "Pathogenesis of cholinergic urticaria in relation to sweating". Allergology International. 61 (4): 539–544. doi:10.2332/allergolint.12-RAI-0485. PMID 23093795.
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