Irina Shayk

In 2007, Shayk replaced Ana Beatriz Barros as the face of Intimissimi,[11] and in the same year debuted in the annual Sports Illustrated Swimsuit Issue.[12]

After being the face of Intimissimi for three years, Shayk was made the official ambassador for the brand in 2010.[9] Her other modeling campaigns included Beach Bunny Swimwear,[13] and Guess for the spring/summer 2009 season.[14] Other work includes the Victoria's Secret catalog, Lacoste, Cesare Paciotti and Morellato. She signed with IMG Models in May 2009.[15]

Shayk modeled the Armani Exchange spring/summer 2010 campaign.[16] She also starred in Kanye West's "Power", directed by artist Marco Brambilla.[17] She was on the cover of Ocean Drive and GQ South Africa for the August issue.[18][19] She ranked first in the "50 Hottest Russian Women" list by Complex magazine.[20]

She made a change from swimwear to high fashion with a spread in Spain's Harper's Bazaar and landed the cover of Elle Spain for their November 2010 issue.[21] Glamour Spain awarded her "Best International Model of 2010".[22] At the end of the year, she was pictured nude in the GQ Spain December issue; however, she claimed that she had not stripped for the photoshoot, and that the magazine had digitally altered the images to remove her lingerie. GQ responded that there are 15 witnesses of her posing nude.[23]

Shayk walking the runway in 2014

On Valentine's Day, in an episode of the Late Show with David Letterman, it was revealed via Billboard that Shayk was the covermodel for the 2011 Sports Illustrated Swimsuit Issue. This was the fifth time she has been featured in the magazine, but the first time she has been on the cover. She is the first Russian to appear on the cover.[24] Shayk became the face of swim label Luli Fama's 2011 advertising campaign and look book.[25][26] In 2011, she covered magazines such as Tatler Russia, Twelv, Cosmopolitan Spain, GQ Mexico, Glamour Spain, Amica Italy and appeared on the covered of Elle Spain, the special edition for Christmas. She also worked for many brands like Rampage, replacing Bar Refaeli, Replay and XTI. She currently ranks 14th in the "Top 20 Sexiest Models" list on Models.com.[27] The same year, she was voted "Sexiest Woman In The World" in the Hungarian magazine Periodika.[28]

In 2012, she covered Esquire UK, Harper's Bazaar Arabia and Ukraine, Marie Claire Ukraine, Spain and Russia, GQ Germany, Glamour Russia and appeared on 14 Cosmopolitan spring covers worldwide. She also covered S Moda Spain and The Sunday Times Style. She also did an editorial for Vanity Fair Italy. The same year, she has appeared in campaigns for Morellato, Agua Bendita and Blanco.[29]

In November, Shayk covered Twelv Magazine, Second Issue with fellow Russian model Anne V.[30] In the same month, she appeared in an editorial for Vogue Spain December issue working with Mario Testino.[31]

In February 2013, she covered Vs. magazine with Anne V and the same month she did an editorial for CR Fashion book issue 2 photographed by Bruce Weber and styled by Carine Roitfeld. The same month, she did the runway of Jeremy Scott during the New York fashion week. In March 2013, she did the runway of Givenchy during the Paris fashion week.[29] Also in 2013, Shayk featured several times in Harper's Bazaar US. She featured for the second time in CR fashion book issue 3. In September, she covered Allure Russia.[32] She was also the cover model of Vogue Spain, landing her first Vogue cover photographed by Giampaolo Sgura.[33] In 2014, she was the placard bearer for the Russian team during the opening ceremony of the 2014 Winter Olympics.[34]

Shayk has walked the runways for Miu Miu, Bottega Veneta, Marc Jacobs, Moschino, Burberry, Versace, Givenchy, Diane Von Furstenberg, Giles Deacon, Desigual, Jeremy Scott, Hugo Boss, Philipp Plein, Salvatore Ferragamo, Valentino, Max Mara, Brandon Maxwell, Isabel Marant, Etro, Vivienne Westwood, Richard Quinn, Oscar de la Renta, Missoni, Michael Kors, and Mango.[35] She even walked for the last Jean Paul Gaultier fashion show in 2020. In 2016, she walked in the Victoria's Secret Fashion Show while 6 months pregnant[36] with baby girl Lea de Seine Shayk Cooper.

She has appeared in advertising campaigns for Burberry, Jean Paul Gaultier, Marc Jacobs, Versace, Alberta Ferretti, Givenchy, Missoni, La Perla, Roberto Cavalli, Giorgio Armani, Dsquared2, La Senza, Morellato, Bebe, Lord & Taylor, Lacoste, Armani Exchange, Guess?, Blumarine, Saks Fifth Avenue, Victoria's Secret, and Avon.[37] In October 2015, she became the new L'Oréal Paris International Spokesperson.[38]

Shayk made her acting debut as Megara alongside Dwayne Johnson in the 2014 film Hercules.[39][40]