Life expectancy

Life expectancy is a statistical measure of the average time an organism is expected to live, based on the year of its birth, current age, and other demographic factors like sex. The most commonly used measure is life expectancy at birth (LEB), which can be defined in two ways. Cohort LEB is the mean length of life of a birth cohort (all individuals born in a given year) and can be computed only for cohorts born so long ago that all their members have died. Period LEB is the mean length of life of a hypothetical cohort[1][2] assumed to be exposed, from birth through death, to the mortality rates observed at a given year.[3]

Life expectancy in USA, China and Russia, 1960–2020
Life expectancy in the largest European countries, 1960–2020
Life expectancy at birth, measured by region, between 1950 and 2050
Life expectancy by world region, from 1770 to 2018
Gender Die Gap: global gender life expectancy gap at birth for countries and territories as defined by WHO for 2019. Open the original svg-file and hover over a bubble to show its data. The square of the bubbles is proportional to country population based on estimation of the UN.

National LEB figures reported by national agencies and international organizations for human populations are estimates of period LEB. In the Bronze Age and the Iron Age, human LEB was 26 years; the 2010 world LEB was 67.2 years. In recent years, LEB in Eswatini (formerly Swaziland) is 49, while LEB in Japan is 83. The combination of high infant mortality and deaths in young adulthood from accidents, epidemics, plagues, wars, and childbirth, before modern medicine was widely available, significantly lowers LEB. For example, a society with a LEB of 40 would have relatively few people dying at exactly 40: most will die before 30 or after 55. In populations with high infant mortality rates, LEB is highly sensitive to the rate of death in the first few years of life. Because of this sensitivity, LEB can be grossly misinterpreted, leading to the belief that a population with a low LEB would have a small proportion of older people.[4] A different measure, such as life expectancy at age 5 (e5), can be used to exclude the effect of infant mortality to provide a simple measure of overall mortality rates other than in early childhood. Aggregate population measures such as the proportion of the population in various age groups, are also used alongside individual-based measures like formal life expectancy when analyzing population structure and dynamics. However, pre-modern societies still had universally higher mortality rates and lower life expectancies at every age for both males and females, and this example was relatively rare. In societies with life expectancies of 30, for instance, a 40-year remaining timespan at age 5 may not have been uncommon, but a 60-year one was.

Until the middle of the 20th century, infant mortality was approximately 40–60% of the total mortality. Excluding child mortality, the average life expectancy during the 12th–19th centuries was approximately 55 years. If a medieval person survived childhood, they had about a 50% chance of living 50–55 years, instead of only 25–40 years.[5]

Mathematically, life expectancy is the mean number of years of life remaining at a given age.[6] It is denoted by ,[a] which is the mean number of subsequent years of life for someone at age , with a particular mortality. Life expectancy, longevity, and maximum lifespan are not synonymous. Longevity refers to the relatively long lifespan of some members of a population. Maximum lifespan is the age at death for the longest-lived individual of a species. Because life expectancy is an average, a particular person may die many years before or many years after the "expected" survival.

Life expectancy is also used in plant or animal ecology,[7] and in life tables (also known as actuarial tables). The concept of life expectancy may also be used in the context of manufactured objects,[8] though the related term shelf life is commonly used for consumer products, and the terms "mean time to breakdown" (MTTB) and "mean time between failures" (MTBF) are used in engineering.

Human patterns

Maximum

Records of human lifespan above age 100 are highly susceptible to errors.[9] For example, the previous world-record holder for human lifespan, Carrie C. White, was uncovered as a simple typographic error after more than two decades.[9] The longest verified lifespan for any human is that of Frenchwoman Jeanne Calment, who is verified as having lived to age 122 years, 164 days, between 21 February 1875 and 4 August 1997. This is referred to as the "maximum life span," which is the upper boundary of life, the maximum number of years any human is known to have lived.[10] A theoretical study shows that the maximum life expectancy at birth is limited by the human life characteristic value δ, which is around 104 years.[11] According to a study by biologists Bryan G. Hughes and Siegfried Hekimi, there is no evidence for limit on human lifespan.[12][13] However, this view has been questioned on the basis of error patterns.[9]

Variation over time

The following information is derived from the 1961 Encyclopædia Britannica and other sources, some with questionable accuracy. Unless otherwise stated, it represents estimates of the life expectancies of the world population as a whole. In many instances, life expectancy varied considerably according to class and gender.

Life expectancy at birth takes account of infant mortality and child mortality but not prenatal mortality.

EraLife expectancy at birth in yearsNotes
Paleolithic22[14] – 33Based on the data from modern hunter-gatherer populations, it is estimated that at 15, life expectancy was an additional 39 years (total 54), with a 60% probability of reaching 15.[15]
Neolithic20[16] – 33[17]Based on Early Neolithic data, total life expectancy at 15 would be 28–33 years.[18]
Bronze Age and Iron Age[19]26Based on Early and Middle Bronze Age data, total life expectancy at 15 would be 28–36 years.[18]
Classical Greece[20]25[21] – 28[22]Based on Athens Agora and Corinth data, total life expectancy at 15 would be 37–41 years.[18] Most Greeks and Romans died young. About half of all children died before adolescence. Those who survived to the age of 30 had a reasonable chance of reaching 50 or 60. The truly elderly, however, were rare. Because so many died in childhood, life expectancy at birth was probably between 20 and 30 years.[23]
Classical Rome20–33

[24][25][26][23][14][27]

 Data is lacking, but computer models provide the estimate. If a person survived to age 20, they could expect to live around 30 years more. Life expectancy was probably slightly longer for women than men.[28]

When infant mortality is factored out [i.e. counting only the 67[24]-75% who survived the first year], life expectancy is around 34–41 more years [i.e. expected to live to 35–42]. When child mortality is factored out [i.e. counting only the 55-65% who survived to age 5], life expectancy is around 40–45 [i.e. age 45–50].[26] The ~50% that reached age 10 could also expect to reach ~45-50;[24] at 15 to ~48–54; at 40 to ~60,[24] at 50 to ~64–68; at 60 to ~70–72; at 70 to ~76–77.[26][28]

Vedic India25-35 30 was considered the average lifespan by Vedic texts.[29]
Wang clan of China, 1st c. AD – 174935For the 60% that survived the first year [i.e. excluding infant mortalities] it rose to ~35.[30][31]
Early Middle Ages (Europe, from the late 5th or early 6th century to the 10th century AD)30–35Life expectancy for those of both sexes who survived birth averaged about 30–35 years. However, if a Gaulish boy made it past age 20, he might expect to live 25 more years while a woman at age 20 could normally expect about 17 years. Anyone who survived until 40 had a good chance at another 15 to 20 years.[32]
Pre-Columbian Mesoamerica[33]>40The average Aztec life expectancy was 41.2 years for men and 42.1 for women.
Late medieval English peerage[34][35]30–33[27]In Europe, around one-third of infants died in their first year.[14] Once children reached the age of 10, their life expectancy was 32.2 years, and for those who survived to 25, the remaining life expectancy was 23.3 years. Such estimates reflected the life expectancy of adult males from the higher ranks of English society in the Middle Ages, and were similar to that computed for monks of the Christ Church in Canterbury during the 15th century.[27] At age 21, life expectancy of an aristocrat was an additional 43 years (total age 64).[36]
Early modern England (16th - 18th cent.)[19]33–4034 years for males in the 18th century.[37] For 15-year-old girls: around the 15th & 16th cent it was ~33 years (48 total), and in the 18th it was ~42 (57 total).[38]
18th-century England[39][14]25–40For most of the century it ranged from 35 to 40; however, in the 20s it dipped as low as 25.[39] For 15-year-old girls, it was ~42 (57 total).[38] During the 2nd half of the century it was ~37,[40] while for the elite it passed 40 and approached 50.[30]
Pre-Champlain Canadian Maritimes[41] 60 Samuel de Champlain wrote that in his visits to Mi'kmaq and Huron communities, he met people over 100 years old. Daniel Paul attributes the incredible lifespan in the region to low stress and a healthy diet of lean meats, diverse vegetables and legumes.[42]
18th-century Prussia[37]24.7For males.[37]
18th-century France[37]27.5–30For males.[37] 24.8 years in 1740–1749, 27.9 years in 1750–1759, 33.9 years in 1800–1809.[31]
18th-century American colonies[14]28Massachusetts colonists who reached the age of 50 could expect to live until 71, and those who were still alive at 60 could expect to reach 75.
Beginning of the 19th century[39]~29Demographic research suggests that at the beginning of the 19th century no country in the world had a life expectancy longer than 40 years. India were ~25, while Belgium was around 40.[39] For Europe as a whole, it was ~33 years.[40]
Early 19th-century England[19][39][30]40For the 84% who survived the first year [i.e. excluding infant mortality], the average age was ~46[30] - 48. If they reached 20 it was ~60, if 50 then ~70, if 70 then ~80.[39] For a 15-year-old girl it was ~60-65.[38] For the upper-class, LEB rose from ~45 to 50.[30]

Another way of thinking about it - less than half of the people born in the mid-19th century made it past their 50th birthday. In contrast, 97% of the people born in 21st century England and Wales can expect to live longer than 50 years.[39]

19th-century British India[43]25.4
19th-century world average[39]28.5–32Over the course of the century: Europe rose from ~33 to 43, the Americas from ~35 to 41, Oceania ~35 to 48, Asia ~28, Africa 26.[39] In 1820s France, LEB was ~38, and for the 80% that survived, it rose to ~47. For Moscow serfs, LEB was ~34, and for the 66% that survived, it rose to ~36.[30] Western Europe in 1830 was ~33 years, while for the people of Hau-Lou in China, it was ~40.[40] The LE for a 10-year-old in Sweden rose from ~44 to ~54.[39]
1900 world average[44]31–32[39]Around 48 in Oceania, 43 in Europe, and 41 in the Americas.[39] ~47 in the U.S.[14] Around 48 for 15-year-old girls in England.[38]
1950 world average[44]45.7[39] – 48Around 60 years in Europe, North America, Oceania, Japan and parts of South America, but only 41 in Asia and 36 in Africa. Norway had double that with 72, while in Mali it was merely 26.[39]
2019-2020 world average72.6–73.2
[39][45][46]		Females: 75.6 years | Males: 70.8 years |

Range: ~54 (Central African Republic) - 85.3 Hong Kong[46]

Life expectancy increases with age as the individual survives the higher mortality rates associated with childhood. For instance, the table gives the life expectancy at birth among 13th-century English nobles at 30. Having survived to the age of 21, a male member of the English aristocracy in this period could expect to live:[36]

  • 1200–1300: to age 64
  • 1300–1400: to age 45 (because of the bubonic plague)
  • 1400–1500: to age 69
  • 1500–1550: to age 71

17th-century English life expectancy was only about 35 years, largely because infant and child mortality remained high. Life expectancy was under 25 years in the early Colony of Virginia,[47] and in seventeenth-century New England, about 40 percent died before reaching adulthood.[48] During the Industrial Revolution, the life expectancy of children increased dramatically.[49] The under-5 mortality rate in London decreased from 74.5% in 1730–1749 to 31.8% in 1810–1829.[50][51]

Public health measures are credited with much of the recent increase in life expectancy. During the 20th century, despite a brief drop due to the 1918 flu pandemic[52] starting around that time the average lifespan in the United States increased by more than 30 years, of which 25 years can be attributed to advances in public health.[53]

The life expectancy for people reaching adulthood is greater, — ignoring infant and child mortality. For instance, 16th Century English and Welsh women at 15 years may have had an life expectancy of around 35 more years (50 total).[38]

Regional variations
Life expectancy in 1800, 1950, and 2015 – visualization by Our World in Data

Human beings are expected to live on average 30–40 years in Eswatini[54] and 82.6 years in Japan, but the latter's recorded life expectancy may have been very slightly increased by counting many infant deaths as stillborn.[55] An analysis published in 2011 in The Lancet attributes Japanese life expectancy to equal opportunities and public health as well as diet.[56][57]

Plot of life expectancy vs. GDP per capita in 2009. This phenomenon is known as the Preston curve.
Graphs of life expectancy at birth for some sub-Saharan countries showing the fall in the 1990s primarily due to the HIV pandemic[58]

There are great variations in life expectancy between different parts of the world, mostly caused by differences in public health, medical care, and diet. The impact of AIDS on life expectancy is particularly notable in many African countries. According to projections made by the United Nations (UN) in 2002, the life expectancy at birth for 2010–2015 (if HIV/AIDS did not exist) would have been:[59]

  • 70.7 years instead of 31.6 years, Botswana
  • 69.9 years instead of 41.5 years, South Africa
  • 70.5 years instead of 31.8 years, Zimbabwe

Actual life expectancy in Botswana declined from 65 in 1990 to 49 in 2000 before increasing to 66 in 2011. In South Africa, life expectancy was 63 in 1990, 57 in 2000, and 58 in 2011. And in Zimbabwe, life expectancy was 60 in 1990, 43 in 2000, and 54 in 2011.[60]

During the last 200 years, African countries have generally not had the same improvements in mortality rates that have been enjoyed by countries in Asia, Latin America, and Europe.[61][62]

In the United States, African-American people have shorter life expectancies than their European-American counterparts. For example, white Americans in 2010 are expected to live until age 78.9, but black Americans only until age 75.1. This 3.8-year gap, however, is the lowest it has been since 1975 at the latest. The greatest difference was 7.1 years in 1993.[63] In contrast, Asian-American women live the longest of all ethnic groups in the United States, with a life expectancy of 85.8 years.[64] The life expectancy of Hispanic Americans is 81.2 years.[63] According to the new government reports in the US, life expectancy in the country dropped again because of the rise in suicide and drug overdose rates. The Centers for Disease Control (CDC) found nearly 70,000 more Americans died in 2017 than in 2016, with rising rates of death among 25- to 44-year-olds.[65]

Cities also experience a wide range of life expectancy based on neighborhood breakdowns. This is largely due to economic clustering and poverty conditions that tend to associate based on geographic location. Multi-generational poverty found in struggling neighborhoods also contributes. In United States cities such as Cincinnati, the life expectancy gap between low income and high-income neighborhoods touches 20 years.[66]

Economic circumstances
Life expectancy is higher in rich countries with low economic inequality.[67]
Life expectancy vs healthcare spending of rich OECD countries[68]

Economic circumstances also affect life expectancy. For example, in the United Kingdom, life expectancy in the wealthiest and richest areas is several years higher than in the poorest areas. This may reflect factors such as diet and lifestyle, as well as access to medical care. It may also reflect a selective effect: people with chronic life-threatening illnesses are less likely to become wealthy or to reside in affluent areas.[69] In Glasgow, the disparity is amongst the highest in the world: life expectancy for males in the heavily deprived Calton area stands at 54, which is 28 years less than in the affluent area of Lenzie, which is only 8 km away.[70][71]

A 2013 study found a pronounced relationship between economic inequality and life expectancy.[72] However, a study by José A. Tapia Granados and Ana Diez Roux at the University of Michigan found that life expectancy actually increased during the Great Depression, and during recessions and depressions in general.[73] The authors suggest that when people are working at a more extreme degree during prosperous economic times, they undergo more stress, exposure to pollution, and the likelihood of injury among other longevity-limiting factors.

Life expectancy is also likely to be affected by exposure to high levels of highway air pollution or industrial air pollution. This is one way that occupation can have a major effect on life expectancy. Coal miners (and in prior generations, asbestos cutters) often have lower life expectancies than average. Other factors affecting an individual's life expectancy are genetic disorders, drug use, tobacco smoking, excessive alcohol consumption, obesity, access to health care, diet, and exercise.

Sex differences
Pink: Countries where female life expectancy at birth is higher than males. Blue: A few countries in southern Africa where females have shorter lives due to AIDS.[74]

In the present, female human life expectancy is greater than that of males, despite females having higher morbidity rates (see Health Survival paradox). There are many potential reasons for this. Traditional arguments tend to favor sociology-environmental factors: historically, men have generally consumed more tobacco, alcohol and drugs than women in most societies, and are more likely to die from many associated diseases such as lung cancer, tuberculosis and cirrhosis of the liver.[75] Men are also more likely to die from injuries, whether unintentional (such as occupational, war or car accidents) or intentional (suicide).[75] Men are also more likely to die from most of the leading causes of death (some already stated above) than women. Some of these in the United States include cancer of the respiratory system, motor vehicle accidents, suicide, cirrhosis of the liver, emphysema, prostate cancer, and coronary heart disease.[10] These far outweigh the female mortality rate from breast cancer and cervical cancer. In the past, mortality rates for females in child-bearing age groups were higher than for males at the same age.

A paper from 2015 found that female fetuses have a higher mortality rate than male fetuses.[76] This finding contradicts papers dating from 2002 and earlier that attribute the male sex to higher in-utero mortality rates.[77][78][79] Among the smallest premature babies (those under 2 pounds or 900 g), females have a higher survival rate. At the other extreme, about 90% of individuals aged 110 are female. The difference in life expectancy between men and women in the United States dropped from 7.8 years in 1979 to 5.3 years in 2005, with women expected to live to age 80.1 in 2005.[80] Data from the UK shows the gap in life expectancy between men and women decreasing in later life. This may be attributable to the effects of infant mortality and young adult death rates.[81]

Some argue that shorter male life expectancy is merely another manifestation of the general rule, seen in all mammal species, that larger-sized individuals within a species tend, on average, to have shorter lives.[82][83] This biological difference occurs because women have more resistance to infections and degenerative diseases.[10]

In her extensive review of the existing literature, Kalben concluded that the fact that women live longer than men was observed at least as far back as 1750 and that, with relatively equal treatment, today males in all parts of the world experience greater mortality than females. Kallen's study, however, was restricted to data in Western Europe alone, where the demographic transition occurred relatively early. United Nations statistics from mid-twentieth century onward, show that in all parts of the world, females have a higher life expectancy at age 60 than males.[84] Of 72 selected causes of death, only 6 yielded greater female than male age-adjusted death rates in 1998 in the United States. Except for birds, for almost all of the animal species studied, males have higher mortality than females. Evidence suggests that the sex mortality differential in people is due to both biological/genetic and environmental/behavioral risk and protective factors.[85]

There is a recent suggestion that mitochondrial mutations that shorten lifespan continue to be expressed in males (but less so in females) because mitochondria are inherited only through the mother. By contrast, natural selection weeds out mitochondria that reduce female survival; therefore such mitochondria are less likely to be passed on to the next generation. This thus suggests that females tend to live longer than males. The authors claim that this is a partial explanation.[86][87]

Another explanation is the unguarded X hypothesis: according to this hypothesis one reason for why the average lifespan of males isn't as long as that of females––by 18% on average according to the study––is that they have a Y chromosome which can't protect an individual from harmful genes expressed on the X chromosome, while a duplicate X chromosome, as present in female organisms, can ensure harmful genes aren't expressed.[88][89]

Before the Industrial Revolution, men lived longer than women on average.[90][91] In developed countries, starting around 1880, death rates decreased faster among women, leading to differences in mortality rates between males and females. Before 1880 death rates were the same. In people born after 1900, the death rate of 50- to 70-year-old men was double that of women of the same age. Men may be more vulnerable to cardiovascular disease than women, but this susceptibility was evident only after deaths from other causes, such as infections, started to decline.[92] Most of the difference in life expectancy between the sexes is accounted for by differences in the rate of death by cardiovascular diseases among persons aged 50–70.[93]

Genetics

The heritability of lifespan is estimated to be less than 10%, meaning the majority of variation in lifespan is attributable due to differences in environment rather than genetic variation.[94] However, researchers have identified regions of the genome which can influence the length of life and the number of years lived in good health. For example, a genome-wide association study of 1 million lifespans found 12 genetic loci which influenced lifespan by modifying susceptibility to cardiovascular and smoking-related disease.[95] The locus with the largest effect is APOE. Carriers of the APOE ε4 allele live approximately one year less than average (per copy of the ε4 allele), mainly due to increased risk of Alzheimer's disease.[95]

"Healthspan, parental lifespan, and longevity are highly genetically correlated."[96]

In July 2020, scientists identified 10 genomic loci with consistent effects across multiple lifespan-related traits, including healthspan, lifespan, and longevity.[96] The genes affected by variation in these loci highlighted haem metabolism as a promising candidate for further research within the field. This study suggests that high levels of iron in the blood likely reduce, and genes involved in metabolising iron likely increase healthy years of life in humans.[97]

A follow-up study which investigated the genetics of frailty and self-rated health in addition to healthspan, lifespan, and longevity also highlighted haem metabolism as an important pathway, and found genetic variants which lower blood protein levels of LPA and VCAM1 were associated with increased healthy lifespan.[98]

Centenarians
Main article: Centenarian

In developed countries, the number of centenarians is increasing at approximately 5.5% per year, which means doubling the centenarian population every 13 years, pushing it from some 455,000 in 2009 to 4.1 million in 2050.[99] Japan is the country with the highest ratio of centenarians (347 for every 1 million inhabitants in September 2010). Shimane Prefecture had an estimated 743 centenarians per million inhabitants.[100]

In the United States, the number of centenarians grew from 32,194 in 1980 to 71,944 in November 2010 (232 centenarians per million inhabitants).[101]

Mental illness

Mental illness is reported to occur in approximately 18% of the average American population.[102][103]

Life expectancy in the seriously mentally ill is much shorter than the general population.[104]

The mentally ill have been shown to have a 10- to a 25-year reduction in life expectancy.[105] Generally, the reduction of lifespan in the mentally ill population compared to the mentally stable population has been studied and documented.[106][107][108][109][110]

The greater mortality of people with mental disorders may be due to death from injury, from co-morbid conditions, or medication side effects.[111] For instance, psychiatric medications can increase the risk of developing diabetes.[112][113][114][115] It has been shown that the psychiatric medication olanzapine can increase risk of developing agranulocytosis among other comorbidities.[116][117] Psychiatric medicines also affect the gastrointestinal tract, where the mentally ill have a four times risk of gastrointestinal disease.[118][119][120]

As of the year 2020 and the COVID-19 pandemic, researchers have found an increased risk of death in the mentally ill.[121][122][123]

Other illnesses

The life expectancy of people with diabetes, which is 9.3% of the U.S. population, is reduced by roughly ten to twenty years.[124][125] People over 60 years old with Alzheimer's disease have about a 50% life expectancy of 3 to 10 years.[126] Other demographics that tend to have a lower life expectancy than average include transplant recipients,[127] and the obese.[128]

Education

Education on all levels has been shown to be strongly associated with increased life expectancy.[129] This association may be due partly to higher income,[130] which can lead to increased life expectancy. Despite the association, among identical twin pairs with different education levels, there is only weak evidence of a relationship between educational attainment and adult mortality.[129]

According to a paper from 2015, the mortality rate for the Caucasian population in the United States from 1993 to 2001 is four times higher for those who did not complete high school compared to those who have at least 16 years of education.[129] In fact, within the U.S. adult population, those who have less than a high school education have the shortest life expectancies.

Pre-school education also plays a large role in life expectancy. It was found that high-quality early-stage childhood education had positive effects on health. Researchers discovered this by analyzing the results of the Carolina Abecedarian Project (ABC) finding that the disadvantaged children who were randomly assigned to treatment had lower instances of risk factors for cardiovascular and metabolic diseases in their mid-30s.[131]

Evolution and aging rate
Main article: Life history theory

Various species of plants and animals, including humans, have different lifespans. Evolutionary theory states that organisms that, by virtue of their defenses or lifestyle, live for long periods and avoid accidents, disease, predation, etc. are likely to have genes that code for slow aging, which often translates to good cellular repair. One theory is that if predation or accidental deaths prevent most individuals from living to an old age, there will be less natural selection to increase the intrinsic life span.[132] That finding was supported in a classic study of opossums by Austad;[133] however, the opposite relationship was found in an equally prominent study of guppies by Reznick.[134][135]

One prominent and very popular theory states that lifespan can be lengthened by a tight budget for food energy called caloric restriction.[136] Caloric restriction observed in many animals (most notably mice and rats) shows a near doubling of life span from a very limited calorific intake. Support for the theory has been bolstered by several new studies linking lower basal metabolic rate to increased life expectancy.[137][138][139] That is the key to why animals like giant tortoises can live so long.[140] Studies of humans with life spans of at least 100 have shown a link to decreased thyroid activity, resulting in their lowered metabolic rate.

In a broad survey of zoo animals, no relationship was found between investment of the animal in reproduction and its life span.[141]

Calculation
A survival tree to explain the calculations of life-expectancy. Red numbers indicate a chance of survival at a specific age, and blue ones indicate age-specific death rates.

The starting point for calculating life expectancy is the age-specific death rates of the population members. If a large amount of data is available, a statistical population can be created that allow the age-specific death rates to be simply taken as the mortality rates actually experienced at each age (the number of deaths divided by the number of years "exposed to risk" in each data cell). However, it is customary to apply smoothing to iron out, as much as possible, the random statistical fluctuations from one year of age to the next. In the past, a very simple model used for this purpose was the Gompertz function, but more sophisticated methods are now used.[142]

These are the most common methods now used for that purpose:

  • to fit a mathematical formula, such as an extension of the Gompertz function, to the data.
  • for relatively small amounts of data, to look at an established mortality table that was previously derived for a larger population and make a simple adjustment to it (as multiply by a constant factor) to fit the data.
  • with a large number of data points, one looks at the mortality rates actually experienced at each age and applies to smooth (as by cubic splines).

While the data required are easily identified in the case of humans, the computation of life expectancy of industrial products and wild animals involves more indirect techniques. The life expectancy and demography of wild animals are often estimated by capturing, marking, and recapturing them.[143] The life of a product, more often termed shelf life, is also computed using similar methods. In the case of long-lived components, such as those used in critical applications: in aircraft, methods like accelerated aging are used to model the life expectancy of a component.[8]

The age-specific death rates are calculated separately for separate groups of data that are believed to have different mortality rates (such as males and females, and perhaps smokers and non-smokers if data are available separately for those groups) and are then used to calculate a life table from which one can calculate the probability of surviving to each age. In actuarial notation, the probability of surviving from age to age is denoted and the probability of dying during age (between ages and ) is denoted . For example, if 10% of a group of people alive at their 90th birthday die before their 91st birthday, the age-specific death probability at 90 would be 10%. That is a probability, not a mortality rate.

The expected future lifetime of a life age in whole years (the curtate expected lifetime of (x)) is denoted by the symbol .[a] It is the conditional expected future lifetime (in whole years), assuming survival to age . If denotes the curtate future lifetime at ,

Substituting in the sum and simplifying gives the equivalent formula:[144] If the assumption is made that on average, people live a half year in the year of death, the complete expectation of future lifetime at age is .

Life expectancy is by definition an arithmetic mean. It can also be calculated by integrating the survival curve from 0 to positive infinity (or equivalently to the maximum lifespan, sometimes called 'omega'). For an extinct or completed cohort (all people born in the year 1850, for example), it can of course simply be calculated by averaging the ages at death. For cohorts with some survivors, it is estimated by using mortality experience in recent years. The estimates are called period cohort life expectancies.

It is important to note that the statistic is usually based on past mortality experience and assumes that the same age-specific mortality rates will continue. Thus, such life expectancy figures need to be adjusted for temporal trends before calculating how long a currently living individual of a particular age is expected to live. Period life expectancy remains a commonly used statistic to summarize the current health status of a population.

However, for some purposes, such as pensions calculations, it is usual to adjust the life table used by assuming that age-specific death rates will continue to decrease over the years, as they have usually done in the past. That is often done by simply extrapolating past trends, but some models exist to account for the evolution of mortality like the Lee–Carter model.[145]

As discussed above, on an individual basis, some factors correlate with longer life. Factors that are associated with variations in life expectancy include family history, marital status, economic status, physique, exercise, diet, drug use including smoking and alcohol consumption, disposition, education, environment, sleep, climate, and health care.[10]

Healthy life expectancy

To assess the quality of these additional years of life, 'healthy life expectancy' has been calculated for the last 30 years. Since 2001, the World Health Organization has published statistics called Healthy life expectancy (HALE), defined as the average number of years that a person can expect to live in "full health" excluding the years lived in less than full health due to disease and/or injury.[146][147] Since 2004, Eurostat publishes annual statistics called Healthy Life Years (HLY) based on reported activity limitations. The United States uses similar indicators in the framework of the national health promotion and disease prevention plan "Healthy People 2010". More and more countries are using health expectancy indicators to monitor the health of their population.

The long-standing quest for longer life led in the 2010s to a more promising focus on increasing HALE, also known as a person's "healthspan". Besides the benefits of keeping people healthier longer, a goal is to reduce health-care expenses on the many diseases associated with cellular senescence. Approaches being explored include fasting, exercise, and senolytic drugs.[148]

Forecasting

Forecasting life expectancy and mortality form an important subdivision of demography. Future trends in life expectancy have huge implications for old-age support programs like U.S. Social Security and pension since the cash flow in these systems depends on the number of recipients who are still living (along with the rate of return on the investments or the tax rate in pay-as-you-go systems). With longer life expectancies, the systems see increased cash outflow; if the systems underestimate increases in life-expectancies, they will be unprepared for the large payments that will occur, as humans live longer and longer.

Life expectancy forecasting is usually based on two different approaches:

  • Forecasting the life expectancy directly, generally using ARIMA or other time-series extrapolation procedures: that has the advantage of simplicity, but it cannot account for changes in mortality at specific ages, and the forecast number cannot be used to derive other life table results. Analyses and forecasts using this approach can be done with any common statistical/mathematical software package, like EViews, R, SAS, Stata, Matlab, or SPSS.
  • Forecasting age-specific death rates and computing the life expectancy from the results with life table methods: that is usually more complex than simply forecasting life expectancy because the analyst must deal with correlated age-specific mortality rates, but it seems to be more robust than simple one-dimensional time series approaches. It also yields a set of age specific-rates that may be used to derive other measures, such as survival curves or life expectancies at different ages. The most important approach within this group is the Lee-Carter model,[149] which uses the singular value decomposition on a set of transformed age-specific mortality rates to reduce their dimensionality to a single time series, forecasts that time series and then recovers a full set of age-specific mortality rates from that forecasted value. The software includes Professor Rob J. Hyndman's R package called 'demography' and UC Berkeley's LCFIT system.

Policy uses

Life expectancy is one of the factors in measuring the Human Development Index (HDI) of each nation along with adult literacy, education, and standard of living.[150]

Life expectancy is also used in describing the physical quality of life of an area or, for an individual when the value of a life settlement is determined a life insurance policy is sold for a cash asset.

Disparities in life expectancy are often cited as demonstrating the need for better medical care or increased social support. A strongly associated indirect measure is income inequality. For the top 21 industrialized countries, if each person is counted equally, life expectancy is lower in more unequal countries (r = −0.907).[151] There is a similar relationship among states in the US (r = −0.620).[152]

Life expectancy vs. maximum life span

Life expectancy is commonly confused with the average age an adult could expect to live. This confusion may create the expectation that an adult would be unlikely to exceed an average life expectancy, even though, with all statistical probability, an adult, who has already avoided many statistical causes of adolescent mortality, should be expected to outlive the average life expectancy calculated from birth.[153] One must compare the life expectancy of the period after childhood, to estimate also the life expectancy of an adult.[153] Life expectancy can change dramatically after childhood, even in preindustrial times as is demonstrated by the Roman Life Expectancy table, which estimates life expectancy to be 25 years at birth, but 53 years upon reaching age 25.[154] Studies like Plymouth Plantation; "Dead at Forty" and Life Expectancy by Age, 1850–2004 similarly show a dramatic increase in life expectancy once adulthood was reached.[155][156]

Life expectancy differs from maximum life span. Life expectancy is an average for all people in the population — including those who die shortly after birth, those who die in early adulthood (e.g. childbirth, war), and those who live unimpeded until old age. Maximum lifespan is an individual-specific concept — maximum lifespan is, therefore, an upper bound rather than an average.[153] Science author Christopher Wanjek said "has the human race increased its life span? Not at all. This is one of the biggest misconceptions about old age." The maximum life span, or oldest age a human can live, may be constant.[153] Further, there are many examples of people living significantly longer than the average life expectancy of their time period, such as Socrates (71), Saint Anthony the Great (105), Michelangelo (88), and John Adams, 2nd president of the United States (90).[153]

However, anthropologist John D. Hawks criticizes the popular conflation of life span (life expectancy) and maximum life span when popular science writers falsely imply that the average adult human does not live longer than their ancestors. He writes, "[a]ge-specific mortality rates have declined across the adult lifespan. A smaller fraction of adults die at 20, at 30, at 40, at 50, and so on across the lifespan. As a result, we live longer on average... In every way we can measure, human lifespans are longer today than in the immediate past, and longer today than they were 2000 years ago... age-specific mortality rates in adults really have reduced substantially."[157]

See also
  • Biodemography
  • Calorie restriction
  • Demography
  • Depreciation
  • DNA damage theory of aging
  • Glasgow effect
  • Healthcare inequality
  • Indefinite lifespan
  • Life table
  • Lindy effect
  • List of countries by life expectancy
  • List of countries by past life expectancy
  • List of longest-living organisms
  • Maximum life span
  • Medieval demography
  • Mitohormesis
  • Mortality rate
  • Population pyramid
  • Senescence

Increasing life expectancy
  • Strategies for engineered negligible senescence (SENS)
  • John Sperling
  • Life extension
  • Longevity
  • Rejuvenation
  • Public health
  • Infant mortality

Explanatory notes

a. ^ ^ In standard actuarial notation, ex refers to the expected future lifetime of (x) in whole years, while eͦx (with a ring above the e) denotes the complete expected future lifetime of (x), including the fraction.

References
  1. ""Life Expectancy" – What does this actually mean?". Our World in Data. Retrieved August 31, 2020.
  2. "Period and cohort life expectancy explained: December 2019 – Office for National Statistics". www.ons.gov.uk. Retrieved August 31, 2020.
  3. S. Shryock, J. S. Siegel et al. The Methods, and Materials of Demography. Washington, DC, US Bureau of the Census, 1973
  4. Laden, Greg (May 1, 2011). "Falsehood: "If this was the Stone Age, I'd be dead by now"". ScienceBlogs. Archived from the original on November 11, 2012. Retrieved August 31, 2014.
  5. Felinah Memo Hazara Khan-ad-Din. "Old Age, Height and Nutrition: Common Misconceptions About Medieval England" (PDF).
  6. Arthur O'Sullivan; Steven M. Sheffrin (2003). Economics: Principles in Action. Pearson Prentice Hall. p. 473. ISBN 978-0-13-063085-8.
  7. John S. Millar; Richard M. Zammuto (1983). "Life Histories of Mammals: An Analysis of Life Tables". Ecology. Ecological Society of America. 64 (4): 631–635. doi:10.2307/1937181. JSTOR 1937181.
  8. Eliahu Zahavi, Vladimir Torbilo & Solomon Press (1996) Fatigue Design: Life Expectancy of Machine Parts. CRC Press. ISBN 0-8493-8970-4.
  9. Newman, Saul Justin (December 20, 2018). "Errors as a primary cause of late-life mortality deceleration and plateaus". PLOS Biology. 16 (12): e2006776. doi:10.1371/journal.pbio.2006776. ISSN 1545-7885. PMC 6301557. PMID 30571676.
  10. Santrock, John (2007). Life Expectancy. A Topical Approach to: Life-Span Development (pp. 128–132). New York, New York: The McGraw-Hill Companies, Inc.
  11. X. Liu (2015). "Life equations for the senescence process". Biochemistry and Biophysics Reports. 4: 228–233. arXiv:1502.00759. doi:10.1016/j.bbrep.2015.09.020. PMC 5669524. PMID 29124208.
  12. "No detectable limit to how long people can live" (Press release). Science Daily. June 28, 2017. Retrieved July 4, 2017.
  13. Hughes, Bryan G.; Hekimi, Siegfried (June 29, 2017). "Many possible maximum lifespan trajectories". Nature. 546 (7660): E8–E9. Bibcode:2017Natur.546E...8H. doi:10.1038/nature22786. PMID 28658230. S2CID 4464500.
  14. Kotre, John N.; Hall, Elizabeth (1997). Seasons of Life: The Dramatic Journey from Birth to Death. University of Michigan Press. pp. 47–49. ISBN 978-0-472-08512-5.
  15. Hillard Kaplan; Kim Hill; Jane Lancaster; A. Magdalena Hurtado (2000). "A Theory of Human Life History Evolution: Diet, Intelligence and Longevity" (PDF). Evolutionary Anthropology. 9 (4): 156–185. doi:10.1002/1520-6505(2000)9:4<156::AID-EVAN5>3.0.CO;2-7. S2CID 2363289. Retrieved September 12, 2010.
  16. Galor, Oded; Moav, Omer (2007). "The Neolithic Revolution and Contemporary Variations in Life Expectancy" (PDF). Brown University Working Paper. Retrieved September 12, 2010.
  17. Angel Lawrence J. (1984), "Health as a crucial factor in the changes from hunting to developed farming in the eastern Mediterranean", Proceedings of Meeting on Paleopathology at the Origins of Agriculture: 51–73
  18. J. Lawrence Angel (May 1969). "The bases of paleodemography". American Journal of Physical Anthropology. 30 (3): 427–437. doi:10.1002/ajpa.1330300314. PMID 5791021.
  19. Galor, Oded; Moav, Omer (2005). "Natural Selection and the Evolution of Life Expectancy" (PDF). Brown University Working Paper. Retrieved November 4, 2010.
  20. Morris, Ian (2004). "Economic Growth in Ancient Greece". Journal of Institutional and Theoretical Economics. 160 (4): 709–742. doi:10.1628/0932456042776050. JSTOR 40752487.
  21. Mogens Herman Hansen, The Shotgun Method, p. 55.
  22. "Mortality". Britannica.com. Retrieved November 4, 2010.
  23. Ryan, Garrett (September 1, 2021). Naked Statues, Fat Gladiators, and War Elephants: Frequently Asked Questions about the Ancient Greeks and Romans. Rowman & Littlefield. p. 44. ISBN 978-1-63388-703-9.
  24. Boatwright, Mary T. (2021). Imperial Women of Rome: Power, Gender, Context. Oxford University Press. p. 87. ISBN 978-0-19-045589-7.
  26. Saller, Richard P. (1997). Patriarchy, Property and Death in the Roman Family. Cambridge University Press. pp. 22–25. ISBN 978-0-521-59978-8.
  27. Carrieri, Maria Patrizia; Serraino, Diego (December 1, 2005). "Longevity of popes and artists between the 13th and the 19th century". International Journal of Epidemiology. 34 (6): 1435–1436. doi:10.1093/ije/dyi211. PMID 16260451.
  28. Frier, Bruce (2009). "Chapter 27: Demographics". The Cambridge Ancient History XI: The High Empire, A.D. 70–192. Cambridge University Press. pp. 788–789. ISBN 9781139054393.
  29. "Longevity and the Indian Tradition". India Future Society. June 3, 2013. Retrieved November 26, 2021.
  30. Maher, George (2021). The Imperial Roman Economy. Kilnamanagh. pp. 123, 137, 123–151. ISBN 978-1-9996262-2-8.
  31. Bagchi, Amiya Kumar (2008). Perilous Passage: Mankind and the Global Ascendancy of Capital. Rowman & Littlefield Publishers. p. 138. ISBN 978-1-4617-0515-4.
  32. Bitel, Lisa M. (October 24, 2002). Women in Early Medieval Europe, 400-1100. Cambridge University Press. ISBN 978-0-521-59773-9.
  33. Krause, Stanford Mc. Life in the Aztec Empire. Brainy Bookstore Mckrause.
  34. "Time traveller's guide to Medieval Britain". Channel4.com. Retrieved November 4, 2010.
  35. "A millennium of health improvement". BBC News. December 27, 1998. Retrieved November 4, 2010.
  36. "Expectations of Life" by H.O. Lancaster (page 8)
  37. Pomeranz, Kenneth (2000), The Great Divergence: China, Europe, and the Making of the Modern World Economy, Princeton University Press, p. 37, ISBN 978-0-691-09010-8
  38. J P Griffin (December 1, 2008). "Changing life expectancy throughout history". Journal of the Royal Society of Medicine. 101 (12): 577. doi:10.1258/JRSM.2008.08K037. ISSN 0141-0768. PMC 2625386. PMID 19092024. Wikidata Q55709331. Note: Author is clearly using the term "life expectancy" to mean total years, as is evident from the fact that a life expectancy of 79.2 is given for a 15 year old girl in 1989.
  39. Roser, Max; Ortiz-Ospina, Esteban; Ritchie, Hannah (2019) [First published in 2013]. "Life Expectancy". Our World in Data. How did life expectancy change over time?.
  40. Li, Bozhong (2021). An Early Modern Economy in China. Cambridge University Press. pp. 246–247. ISBN 978-1-108-47920-2.
  41. Francis, Daniel (2006). Voices and Visions: A Story of Canada. Canada: Oxford University Press. p. 21. ISBN 978-0-19-542169-9.
  42. Paul, Daniel N. (1993). We Were Not the Savages: A Micmac Perspective on the Collision of European and Aboriginal Civilizations (1st ed.). Nimbus. ISBN 978-1-55109-056-6.
  43. "Life expectancy". Our World in Data. Retrieved August 28, 2018.
  44. Prentice, Thomson. "Health, history and hard choices: Funding dilemmas in a fast-changing world" (PDF). World Health Organization: Global Health Histories. Retrieved November 4, 2010.
  45. 72.6 72.7
  46. "Life Expectancy by Country and in the World - Worldometer". www.worldometers.info.
  47. "", Stratfordhall.org. Archived 15 February 2020 at the Wayback Machine
  48. "Death in Early America Archived December 30, 2010, at the Wayback Machine". Digital History.
  49. "Modernization – Population Change". Encyclopædia Britannica.
  50. Mabel C. Buer, Health, Wealth and Population in the Early Days of the Industrial Revolution, London: George Routledge & Sons, 1926, page 30 ISBN 0-415-38218-1
  51. BBC—History—The Foundling Hospital. Published: May 1, 2001.
  52. "Gapminder World".
  53. CDC (1999). "Ten great public health achievements—United States, 1900–1999". MMWR Morb Mortal Wkly Rep. 48 (12): 241–3. PMID 10220250. Reprinted in: "From the Centers for Disease Control and Prevention. Ten great public health achievements—United States, 1900–1999". JAMA. 281 (16): 1481. 1999. doi:10.1001/jama.281.16.1481. PMID 10227303.
  54. "The World Factbook — Central Intelligence Agency". November 4, 2021.
  55. Ansley J. Coale; Judith Banister (December 1996). "Five decades of missing females in China". Proceedings of the American Philosophical Society. 140 (4): 421–450. JSTOR 987286. Also printed as Coale AJ, Banister J (August 1994). "Five decades of missing females in China". Demography. 31 (3): 459–79. doi:10.2307/2061752. JSTOR 2061752. PMID 7828766. S2CID 24724998.
  56. Boseley, Sarah (August 30, 2011). "Japan's life expectancy 'down to equality and public health measures'". The Guardian. London. Retrieved August 31, 2011. Japan has the highest life expectancy in the world but the reasons says an analysis, are as much to do with equality and public health measures as diet.... According to a paper in a Lancet series on healthcare in Japan....
  57. Ikeda, Nayu; Saito, Eiko; Kondo, Naoki; Inoue, Manami; Ikeda, Shunya; Satoh, Toshihiko; Wada, Koji; Stickley, Andrew; Katanoda, Kota; Mizoue, Tetsuya; Noda, Mitsuhiko; Iso, Hiroyasu; Fujino, Yoshihisa; Sobue, Tomotaka; Tsugane, Shoichiro; Naghavi, Mohsen; Ezzati, Majid; Shibuya, Kenji (August 2011). "What has made the population of Japan healthy?". The Lancet. 378 (9796): 1094–105. doi:10.1016/S0140-6736(11)61055-6. PMID 21885105. S2CID 33124920. Reduction in health inequalities with improved average population health was partly attributable to equal educational opportunities and financial access to care.
  58. "Life expectancy at birth, total (years)—Data".
  59. ""World Population Prospects—The 2002 Revision", 2003, page 24".
  60. "GHO—By category—Life expectancy—Data by country".
  61. "Wealth & Health of Nations". Gapminder. Retrieved June 26, 2015.
  62. "Life Expectancy | Visual Data". BestLifeRates.org. March 23, 2015. Retrieved June 26, 2015.
  63. "Deaths: Final Data for 2010", National Vital Statistics Reports, authored by Sherry L. Murphy, Jiaquan Xu, and Kenneth D. Kochanek, volume 61, number 4, page 12, 8 May 2013
  64. United States Department of Health and Human Services, Office of Minority Health—Asian American/Pacific Islander Profile Archived February 4, 2012, at the Wayback Machine. Retrieved October 1, 2013.
  65. "Drug and suicide deaths rise as US life expectancy drops". BBC News. November 30, 2018.
  66. "The Root Causes of Poverty". Waterfields. Retrieved March 4, 2015.
  67. Wilkinson, Richard & Kate Pickett (2009). The Spirit Level: Why Greater Equality Makes Societies Stronger. Bloomsbury Press. ISBN 978-1608190362.
  68. Link between health spending and life expectancy: US is an outlier. May 26, 2017. By Max Roser at Our World in Data. Click the sources tab under the chart for info on the countries, healthcare expenditures, and data sources. See the later version of the chart here.
  69. Department of Health—Tackling health inequalities: Status report on the Programme for Action
  70. "Social factors key to ill health". BBC News. August 28, 2008. Retrieved August 28, 2008.
  71. "GP explains life expectancy gap". BBC News. August 28, 2008. Retrieved August 28, 2008.
  72. Fletcher, Michael A. (March 10, 2013). "Research ties economic inequality to gap in life expectancy". Washington Post. Retrieved March 23, 2013.
  73. "Did The Great Depression Have A Silver Lining? Life Expectancy Increased By 6.2 Years". September 29, 2009. Retrieved April 3, 2011.
  74. PELE, Laurent. "How long will I live? Estimate remaining life expectancy for all countries in the world".
  75. World Health Organization (2004). "Annex Table 2: Deaths by cause, sex and mortality stratum in WHO regions, estimates for 2002" (PDF). The world health report 2004 – changing history. Retrieved November 1, 2008.
  76. "The human sex ratio from conception to birth" Steven Hecht Orzack, J. William Stubblefield, Viatcheslav R. Akmaev, Pere Colls, Santiago Munné, Thomas Scholl, David Steinsaltz, and James E. Zuckerman PNAS April 21, 2015 112 (16) E2102-E2111; first published March 30, 2015 https://doi.org/10.1073/pnas.1416546112.
  77. Kalben, Barbara Blatt. "Why Men Die Younger: Causes of Mortality Differences by Sex". Society of Actuaries", 2002, p. 17.http://www.soa.org/library/monographs/life/why-men-die-younger-causes-of-mortality-differences-by-sex/2001/january/m-li01-1-05.pdf
  78. Tatter, Dorothy; Blanc, William A.; Wright, David L.; Burt, Leslie S.; Naeye, Richard L. (December 1, 1971). "Neonatal Mortality, the Male Disadvantage". Pediatrics. 48 (6): 902–906. doi:10.1542/peds.48.6.902. ISSN 0031-4005. PMID 5129451.
  79. Waldron, Ingrid (January 1, 1983). "Sex differences in human mortality: The role of genetic factors". Social Science & Medicine. 17 (6): 321–333. doi:10.1016/0277-9536(83)90234-4. ISSN 0277-9536. PMID 6344225.
  80. Hitti, Miranda (February 28, 2005). "U.S. Life Expectancy Best Ever, Says CDC". eMedicine. WebMD. Retrieved January 18, 2011.
  81. "Life expectancy—care quality indicators". QualityWatch. Nuffield Trust & Health Foundation. Retrieved April 16, 2015.
  82. "Telemores, sexual size dimorphism and gender gap in life expectancy". Jerrymondo.tripod.com. Retrieved November 4, 2010.
  83. Samaras Thomas T., Heigh Gregory H. "How human size affects longevity and mortality from degenerative diseases". Townsend Letter for Doctors & Patients. 159 (78–85): 133–139.
  84. United Nations, Department of Economic and Social Affairs, Population Division p. 53. "World Population Ageing 2015 (ST/ESA/SER.A/390)" (PDF). un.org. United Nations. Retrieved March 11, 2021.
  85. Kalben, Barbara Blatt. Why Men Die Younger: Causes of Mortality Differences by Sex Archived July 1, 2013, at the Wayback Machine Society of Actuaries, 2002.
  86. "Fruit flies offer DNA clue to why women live longer". BBC News. August 2, 2012 – via bbc.co.uk.
  87. Evolutionary biologist, PZ Myers Mother's Curse
  88. "Why men (and other male animals) die younger: It's all in the Y chromosome". phys.org. Retrieved April 5, 2020.
  89. Xirocostas, Zoe A.; Everingham, Susan E.; Moles, Angela T. (March 25, 2020). "The sex with the reduced sex chromosome dies earlier: a comparison across the tree of life". Biology Letters. 16 (3): 20190867. doi:10.1098/rsbl.2019.0867. PMC 7115182. PMID 32126186.
  90. Bullough and Campbell, Female Longevity and Diet in the Middle Ages
  91. Berlin, Stolnitz & Tenenbein, Mortality Trends of Males and Females Over The Ages
  92. "When Did Women Start to Outlive Men?". Live Science. July 6, 2015. Retrieved July 8, 2015.
  93. Hiram Beltrán-Sánchez, Caleb E. Finch, and Eileen M. Crimmins. "Twentieth-century surge of excess adult male mortality." PNAS July 21, 2015 112 (29) 8993–8998; published ahead of print July 6, 2015 https://doi.org/10.1073/pnas.1421942112.
  94. Ruby, J.G.; Wright, K.M.; Rand, K.A.; Kermany, A.; Noto, K.; Curtis, D; Varner, N.; Garrigan, D.; Slinkov, D.; Dorfman, I.; Granka, J.M.; Byrnes, J.; Myres, N.; Ball, C. (November 2018). "Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating". Genetics. 210 (3): 1109–1124. doi:10.1534/genetics.118.301613. PMC 6218226. PMID 30401766.
  95. Timmers, P.R.H.J.; Mounier, N.; Lall, K.; Fischer, K.; Ning, Z.; Feng, X.; Bretherick, A.D.; Clark, D.W.; eQTLGen Consortium; Shen, X.; Esko, T.; Kutalik, Z.; Wilson, J.F.; Joshi, P.K. (January 2019). "Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances". eLife. 8 (e39856). doi:10.7554/eLife.39856. PMC 6333444. PMID 30642433.
  96. Timmers, Paul R. H. J.; Wilson, James F.; Joshi, Peter K.; Deelen, Joris (July 16, 2020). "Multivariate genomic scan implicates novel loci and haem metabolism in human ageing". Nature Communications. 11 (1): 3570. Bibcode:2020NatCo..11.3570T. doi:10.1038/s41467-020-17312-3. ISSN 2041-1723. PMC 7366647. PMID 32678081.
  97. "Blood iron levels could be key to slowing ageing, gene study shows". phys.org. Retrieved August 18, 2020.
  98. Timmers, P.R.H.J.; Tiys, E.S.; Sakaue, S.; Akiyama, M.; Kiiskinen, T.T.J.; Zhou, W.; Hwang, S.; Yao, C.; Biobank Japan Project; FinnGen; Deelen, J.; Levy, D.; Ganna, A.; Kamatani, Y.; Okada, Y.; Joshi, P.K.; Wilson, J.F.; Tsepilov, Y.A. (January 2022). "Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging". Nature Aging. 2: 19–30. doi:10.1038/s43587-021-00159-8. S2CID 246093885.
  99. United Nations "World Population Ageing 2009"; ST/ESA/SER.A/295, Population Division, Department of Economic and Social Affairs, United Nations, New York, Oct. 2010, liv + 73 pp.
  100. Japan Times "Centenarians to Hit Record 44,000". The Japan Times, September 15, 2010. Okinawa 667 centenarians per 1 million inhabitants in September 2010, had been for a long time the Japanese prefecture with the largest ratio of centenarians, partly because it also had the largest loss of young and middle-aged population during the Pacific War.
  101. "Resident Population. National Population Estimates for the 2000s. Monthly Postcensal Resident Population, by single year of age, sex, race, and Hispanic Origin" Archived October 10, 2013, at the Wayback Machine, Bureau of the Census (updated monthly). Different figures, based on earlier assumptions (104,754 centenarians on Nov.1, 2009) are provided in "Older Americans Month: May 2010" Archived February 16, 2016, at the Wayback Machine, Bureau of the Census, Facts for Features, March 2, 2010, 5 pp.
  102. "Nearly 1 in 5 Americans Suffers From Mental Illness Each Year". Newsweek. February 28, 2014.
  103. Silove, Derrick; Patel, Vikram; Jackson, John W.; Chey, Tien; Iranpour, Changiz; Marnane, Claire; Steel, Zachary (April 2014). "The global prevalence of common mental disorders: A systematic review and meta-analysis 1980–2013". International Journal of Epidemiology. 43 (2): 476–493. doi:10.1093/ije/dyu038. PMC 3997379. PMID 24648481.
  104. "Morbidity and Mortality in People With Serious Mental Illness" (PDF). National Association of State Mental Health Program Directors. 2006.
  105. Khullar, Dhruv (May 30, 2018). "The Largest Health Disparity We Don't Talk About". The New York Times.
  106. Wahlbeck, Kristian; Westman, Jeanette; Nordentoft, Merete; Gissler, Mika; Laursen, Thomas Munk (December 1, 2011). "Outcomes of Nordic mental health systems: life expectancy of patients with mental disorders". Br J Psychiatry. 199 (6): 453–458. doi:10.1192/bjp.bp.110.085100. PMID 21593516.
  107. Reininghaus, Ulrich; Dutta, Rina; Dazzan, Paola; Doody, Gillian A.; Fearon, Paul; Lappin, Julia; Heslin, Margaret; Onyejiaka, Adanna; Donoghue, Kim; Lomas, Ben; Kirkbride, James B.; Murray, Robin M.; Croudace, Tim; Morgan, Craig; Jones, Peter B. (September 27, 2014). "Mortality in Schizophrenia and Other Psychoses: A 10-Year Follow-up of the ӔSOP First-Episode Cohort". Schizophr Bull. 41 (3): 664–73. doi:10.1093/schbul/sbu138. PMC 4393685. PMID 25262443 – via schizophreniabulletin.oxfordjournals.org.
  108. Laursen TM, Munk-Olsen T, Vestergaard M (March 2012). "Life expectancy and cardiovascular mortality in persons with schizophrenia". Curr Opin Psychiatry. 25 (2): 83–8. doi:10.1097/YCO.0b013e32835035ca. PMID 22249081. S2CID 13646442.
  109. "Antipsychotics Linked to Mortality in Parkinson's". Medscape. Retrieved April 9, 2018.
  110. Rosenbaum Lisa (2016). "Closing the Mortality Gap — Mental Illness and Medical Care". New England Journal of Medicine. 375 (16): 1585–1589. doi:10.1056/NEJMms1610125. PMID 27797313.
  111. "Inquest told there was a "lost opportunity" to treat mental health patient who died following severe constipation".
  112. Kumar PN, Thomas B (2011). "Hyperglycemia associated with olanzapine treatment". Indian J Psychiatry. 53 (2): 176–7. doi:10.4103/0019-5545.82562. PMC 3136028. PMID 21772658.
  113. "Lilly Adds Strong Warning Label to Zyprexa, a Schizophrenia Drug". The New York Times. October 6, 2007. Retrieved April 9, 2018.
  114. Codario, Ronald A. (October 28, 2007). Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome. Springer Science & Business Media. ISBN 9781592599325 – via Google Books.
  115. "Antipsychotic-Related Metabolic Testing Falls Far Short". MedScape. Retrieved April 9, 2018.
  116. Jose Ma. J. Alvir (1993). "Clozapine-Induced Agranulocytosis -- Incidence and Risk Factors in the United States". New England Journal of Medicine. 329 (3): 162–167. doi:10.1056/NEJM199307153290303. PMID 8515788.
  117. "Zyprexa Prescribing Information" (PDF). U.S. Food Drug and Administration. 2010.
  118. Philpott, H L; Nandurkar, S; Lubel, J; Gibson, P R (January 2014). "Drug-induced gastrointestinal disorders". Frontline Gastroenterology. 5 (1): 49–57. doi:10.1136/flgastro-2013-100316. ISSN 2041-4137. PMC 5369702. PMID 28839751.
  119. Rege S, Lafferty T (2008). "Life-threatening constipation associated with clozapine". Australas Psychiatry. 16 (3): 216–9. doi:10.1080/10398560701882203. PMID 18568631. S2CID 32093594.
  120. Hibbard KR, Propst A, Frank DE, Wyse J (2009). "Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports". Psychosomatics. 50 (4): 416–9. doi:10.1176/appi.psy.50.4.416. PMID 19687183.
  121. "Association of Psychiatric Disorders With Mortality Among Patients With COVID-19". Date January 27 2021. Authors Katlyn Nemani, Chenxiang Li, Mark Olfson. doi:10.1001/jamapsychiatry.2020.4442
  122. "Increased risk of COVID-19 infection and mortality in people with mental disorders: analysis from electronic health records in the United States." Date October 7 2020. Authors QuanQiu Wang, Rong Xu, Nora D. Volkow. doi.org/10.1002/wps.20806
  123. "Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Infection" Date September 30, 2020 . Authors Luming Li, Fangyong Li, Frank Fortunati. doi:10.1001/jamanetworkopen.2020.23282
  124. "Diabetes Life Expectancy – Type 1 and Type 2 Life Expectancy". January 15, 2019.
  125. Centers for Disease Control and Prevention
  126. Zanetti O, Solerte SB, Cantoni F (2009). "Life expectancy in Alzheimer's disease (AD)". Archives of Gerontology and Geriatrics. 49 Suppl 1: 237–43. doi:10.1016/j.archger.2009.09.035. PMID 19836639.
  127. Kiberd, Bryce A.; Keough-Ryan, Tammy; Clase, Catherine M. (2003). "Screening for prostate, breast and colorectal cancer in renal transplant recipients". American Journal of Transplantation. 3 (5): 619–625. doi:10.1034/j.1600-6143.2003.00118.x. PMID 12752319. S2CID 20247054.
  128. Diehr Paula; et al. (2008). "Weight, mortality, years of healthy life, and active life expectancy in older adults". Journal of the American Geriatrics Society. 56 (1): 76–83. doi:10.1111/j.1532-5415.2007.01500.x. PMC 3865852. PMID 18031486.
  129. Hummer, Robert A.; Hernandez, Elaine M. (June 2013). "The Effect of Educational Attainment on Adult Mortality in the United States*". Population Bulletin. 68 (1): 1–16. ISSN 0032-468X. PMC 4435622. PMID 25995521.
  130. Torpey, Elka. "Measuring the value of education : Career Outlook: U.S. Bureau of Labor Statistics". bls.gov. Retrieved March 10, 2019.
  131. Campbell, Frances & Conti, Gabriella & Heckman, James & Moon, Seong & Pinto, Rodrigo & Pungello, Elizabeth & Pan, Yi. (2014). Early Childhood Investments Substantially Boost Adult Health. Science. 343. 1478–85. 10.1126/science.1248429.
  132. Williams G (1957). "Pleiotropy, natural selection, and the evolution of senescence". Evolution. Society for the Study of Evolution. 11 (4): 398–411. doi:10.2307/2406060. JSTOR 2406060.
  133. Austad SN (1993). "Retarded senescence in an insular population of Virginia opossums". J. Zool. Lond. 229 (4): 695–708. doi:10.1111/j.1469-7998.1993.tb02665.x.
  134. Reznick DN, Bryant MJ, Roff D, Ghalambor CK, Ghalambor DE (2004). "Effect of extrinsic mortality on the evolution of senescence in guppies". Nature. 431 (7012): 1095–1099. Bibcode:2004Natur.431.1095R. doi:10.1038/nature02936. PMID 15510147. S2CID 205210169.
  135. Mitteldorf J, Pepper J (2007). "How can evolutionary theory accommodate recent empirical results on organismal senescence?". Theory in Biosciences. 126 (1): 3–8. doi:10.1007/s12064-007-0001-0. PMID 18087751. S2CID 7305206.
  136. Kirkwood TE (1977). "Evolution of aging". Nature. 270 (5635): 301–304. Bibcode:1977Natur.270..301K. doi:10.1038/270301a0. PMID 593350. S2CID 492012.
  137. Hulbert, A. J.; Pamplona, Reinald; Buffenstein, Rochelle; Buttemer, W. A. (October 1, 2007). "Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals" (PDF). Physiol. Rev. 87 (4): 1175–1213. doi:10.1152/physrev.00047.2006. PMID 17928583. S2CID 11903260. Archived from the original (PDF) on February 18, 2019.
  138. Olshansky, S J; Rattan, Suresh IS (July 25, 2009). "What Determines Longevity: Metabolic Rate or Stability?". Discovery Medicine. 5 (28): 359–362. PMID 20704872.
  139. Aguilaniu, Hugo; Durieux, Jenni; Dillin, Andrew (October 15, 2005). "Metabolism, ubiquinone synthesis, and longevity". Genes Dev. 19 (20): 2399–2406. doi:10.1101/gad.1366505. PMID 16230529.
  140. "The Longevity Secret for Tortoises Is Held In Their Low Metabolism Rate". Archived from the original on November 12, 2013.
  141. Ricklefs RE, Cadena CD (2007). "Lifespan is unrelated to investment in reproduction in populations of mammals and birds in captivity". Ecol. Lett. 10 (10): 867–872. doi:10.1111/j.1461-0248.2007.01085.x. PMID 17845285.
  142. Anderson, Robert N. (1999) Method for constructing complete annual U.S. life tables. Vital and health statistics. Series 2, Data Evaluation, and methods research; no. 129 (DHHS publication no. (PHS) 99-1329) PDF
  143. Linda J Young; Jerry H Young (1998) Statistical ecology: a population perspective. Kluwer Academic Publishers, p. 310
  144. R. Cunningham; T. Herzog; R. London (2008). Models for Quantifying Risk (Third ed.). Actex. ISBN 978-1-56698-676-2. page 92.
  145. Ronald D. Lee and Lawrence Carter. 1992. "Modeling and Forecasting the Time Series of U.S. Mortality," Journal of the American Statistical Association 87 (September): 659–671.
  146. "Healthy life expectancy (HALE) at 60 (years)". World Health Organization.
  147. "Health Status Statistics: Mortality". World Health Organization. Archived from the original on July 4, 2012.
  148. Lawton, Graham (April 24, 2019). "Anti-ageing drugs are coming that could keep you healthier for longer". New Scientist. Retrieved May 2, 2019.
  149. "The Lee-Carter Method for Forecasting Mortality, with Various Extensions and Applications – SOA" (PDF). SOA. Retrieved April 9, 2018.
  150. "International Human Development Indicators—UNDP". Hdrstats.undp.org. Archived from the original on April 20, 2009. Retrieved November 4, 2010.
  151. De Vogli, R. (2005). "Has the relation between income inequality and life expectancy disappeared? Evidence from Italy and top industrialised countries". Journal of Epidemiology & Community Health. 59 (2): 158–162. doi:10.1136/jech.2004.020651. PMC 1733006. PMID 15650149.
  152. Kaplan, G. A; Pamuk, E. R; Lynch, J. W; Cohen, R. D; Balfour, J. L (1996). "Inequality in income and mortality in the United States: analysis of mortality and potential pathways". BMJ. 312 (7037): 999–1003. doi:10.1136/bmj.312.7037.999. PMC 2350835. PMID 8616393.
  153. Wanjek, Christopher (2002), Bad Medicine: Misconceptions and Misuses Revealed, from Distance Healing to Vitamin O, Wiley, pp. 70–71, ISBN 978-0471434993.
  154. Frier, "Demography", 789.
  155. "Common Myths – "Dead at Forty"". July 13, 2007. Archived from the original on July 13, 2007.
  156. "Life Expectancy by Age, 1850–2011". InfoPlease.
  157. Hawks, John (2009), Human lifespans have not been constant for the last 2000 years.

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