Fluorolintano

Fluorolintano
Identificadores
PubChem	137332216
ChemSpider	58838621
UNII	S8L5P832B3
Datos químicos
Fórmula	C18H20NF
	InChI InChI=1S/C18H20FN/c19-17-11-5-4-10-16(17)18(20-12-6-7-13-20)14-15-8-2-1-3-9-15/h1-5,8-11,18H,6-7,12-14H2; Key: ZAGWVXYVNFPCLW-UHFFFAOYSA-N

El fluorolintano (abreviado 2-FPPP y 2-F-DPPy ) es un fármaco anestésico disociativo que se ha vendido en línea como fármaco de diseño.[1][2][3][4]

El fluorolintano y otras diariletilaminas relacionadas son antagonistas del receptor NMDA[5] y se han estudiado en investigaciones in vitro como tratamientos potenciales para ciertas lesiones neurotóxicas,[6] la depresión[7] y como simpaticomiméticos .[8]

Véase también

AD-1211
difenidina
efenidina
Lanicemine
Metoxfenidina (MXP)
Prolintano
Remacemida

Referencias

Wallach J, Kavanagh PV, McLaughlin G, Morris N, Power JD, Elliott SP, Mercier MS, Lodge D, Morris H, Dempster NM, Brandt SD (May 2015). «Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers». Drug Testing and Analysis 7 (5): 358-67. PMID 25044512. doi:10.1002/dta.1689.
«Analytical Report - Fluorolintane». Nacionalni forenzični laboratorij (NFL). January 2016.
Wallach, Jason; Colestock, Tristan; Agramunt, Julià; Claydon, Matt D. B.; Dybek, Michael; Filemban, Nadine; Chatha, Muhammad; Halberstadt, Adam L. et al. (August 2019). «Pharmacological characterizations of the 'legal high' fluorolintane and isomers». European Journal of Pharmacology 857: 172427. ISSN 0014-2999. PMC 6899220. PMID 31152702. doi:10.1016/j.ejphar.2019.172427.
Dybek, Michael; Wallach, Jason; Kavanagh, Pierce V.; Colestock, Tristan; Filemban, Nadine; Dowling, Geraldine; Westphal, Folker; Elliott, Simon P. et al. (August 2019). «Syntheses and analytical characterizations of the research chemical 1-[1-(2-fluorophenyl)-2-phenylethyl]pyrrolidine (fluorolintane) and five of its isomers». Drug Testing and Analysis 11 (8): 1144-1161. ISSN 1942-7611. PMID 31033229. doi:10.1002/dta.2608.
Berger ML, Schweifer A, Rebernik P, Hammerschmidt F (May 2009). «NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds». Bioorganic & Medicinal Chemistry 17 (9): 3456-62. PMID 19345586. doi:10.1016/j.bmc.2009.03.025.
«Patent EP 0346791 B1 - 1,2-diarylethylamines for treatment of neurotoxic injury». 1994.
«Patent US 3083139 A - Therapeutic 1-(1, 2-diphenylethyl) pyrrolidine for the management of depression». 1963.
Heinzelman RV, Aspergren BD (July 1953). «Compounds Containing the Pyrrolidine Ring. Analogs of Sympathomimetic Amines». Journal of the American Chemical Society 75 (14): 3409-3413. doi:10.1021/ja01110a033.

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[1] Wallach J, Kavanagh PV, McLaughlin G, Morris N, Power JD, Elliott SP, Mercier MS, Lodge D, Morris H, Dempster NM, Brandt SD (May 2015). «Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers». Drug Testing and Analysis 7 (5): 358-67. PMID 25044512. doi:10.1002/dta.1689.

[2] «Analytical Report - Fluorolintane». Nacionalni forenzični laboratorij (NFL). January 2016.

[3] Wallach, Jason; Colestock, Tristan; Agramunt, Julià; Claydon, Matt D. B.; Dybek, Michael; Filemban, Nadine; Chatha, Muhammad; Halberstadt, Adam L. et al. (August 2019). «Pharmacological characterizations of the 'legal high' fluorolintane and isomers». European Journal of Pharmacology 857: 172427. ISSN 0014-2999. PMC 6899220. PMID 31152702. doi:10.1016/j.ejphar.2019.172427.

[4] Dybek, Michael; Wallach, Jason; Kavanagh, Pierce V.; Colestock, Tristan; Filemban, Nadine; Dowling, Geraldine; Westphal, Folker; Elliott, Simon P. et al. (August 2019). «Syntheses and analytical characterizations of the research chemical 1-[1-(2-fluorophenyl)-2-phenylethyl]pyrrolidine (fluorolintane) and five of its isomers». Drug Testing and Analysis 11 (8): 1144-1161. ISSN 1942-7611. PMID 31033229. doi:10.1002/dta.2608.

[5] Berger ML, Schweifer A, Rebernik P, Hammerschmidt F (May 2009). «NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds». Bioorganic & Medicinal Chemistry 17 (9): 3456-62. PMID 19345586. doi:10.1016/j.bmc.2009.03.025.

[6] «Patent EP 0346791 B1 - 1,2-diarylethylamines for treatment of neurotoxic injury». 1994.

[7] «Patent US 3083139 A - Therapeutic 1-(1, 2-diphenylethyl) pyrrolidine for the management of depression». 1963.

[8] Heinzelman RV, Aspergren BD (July 1953). «Compounds Containing the Pyrrolidine Ring. Analogs of Sympathomimetic Amines». Journal of the American Chemical Society 75 (14): 3409-3413. doi:10.1021/ja01110a033.