GCN5L2

Histona acetiltransferasa KAT2A
	; Estructura tridimensional de la proteína GCN5L2.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1f68
Identificadores
Símbolos	GCN5L2 (HGNC: 4201) GCN5; MGC102791; PCAF-b; hGCN5
Identificadores; externos	OMIM: 602301 ; EBI: GCN5L2; GeneCards: Gen GCN5L2; UniProt: GCN5L2;
Locus	Cr. 17 q21.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
2648
Q92830	n/a
NP_066564	n/a

La histona acetiltransferasa KAT2A (GCN5L2) es una enzima con actividad histona acetiltransferasa codificada en humanos por el gen KAT2A.[1][2]

Interacciones

La proteína GCN5L2 ha demostrado ser capaz de interaccionar con:

Ku70[3]
TAF9[4]
SUPT3H[5][4]
TADA2L[3][6]
Ku80[3]
DDB1[4]

Referencias

Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL (Feb de 1996). «Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5». Mol Cell Biol 16 (2): 593-602. PMC 231038. PMID 8552087.
«Entrez Gene: GCN5L2 GCN5 general control of amino-acid synthesis 5-like 2 (yeast)».
Barlev, N A; Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman J L, Berger S L (Mar. de 1998). «Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1349-58. ISSN 0270-7306. PMID 9488450.
Martinez, E; Palhan V B, Tjernberg A, Lymar E S, Gamper A M, Kundu T K, Chait B T, Roeder R G (Oct. de 2001). «Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo». Mol. Cell. Biol. (United States) 21 (20): 6782-95. ISSN 0270-7306. PMID 11564863. doi:10.1128/MCB.21.20.6782-6795.2001.
Brand, M; Moggs J G, Oulad-Abdelghani M, Lejeune F, Dilworth F J, Stevenin J, Almouzni G, Tora L (Jun. de 2001). «UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation». EMBO J. (England) 20 (12): 3187-96. ISSN 0261-4189. PMID 11406595. doi:10.1093/emboj/20.12.3187.
Wang, L; Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis C D, Berger S L (Jan. de 1997). «Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation». Mol. Cell. Biol. (UNITED STATES) 17 (1): 519-27. ISSN 0270-7306. PMID 8972232.

Datos: Q18025658

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[pmid8552087-1] Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL (Feb de 1996). «Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5». Mol Cell Biol 16 (2): 593-602. PMC 231038. PMID 8552087.

[entrez-2] «Entrez Gene: GCN5L2 GCN5 general control of amino-acid synthesis 5-like 2 (yeast)».

[pmid9488450-3] Barlev, N A; Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman J L, Berger S L (Mar. de 1998). «Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1349-58. ISSN 0270-7306. PMID 9488450.

[pmid11564863-4] Martinez, E; Palhan V B, Tjernberg A, Lymar E S, Gamper A M, Kundu T K, Chait B T, Roeder R G (Oct. de 2001). «Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo». Mol. Cell. Biol. (United States) 21 (20): 6782-95. ISSN 0270-7306. PMID 11564863. doi:10.1128/MCB.21.20.6782-6795.2001.

[pmid11406595-5] Brand, M; Moggs J G, Oulad-Abdelghani M, Lejeune F, Dilworth F J, Stevenin J, Almouzni G, Tora L (Jun. de 2001). «UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation». EMBO J. (England) 20 (12): 3187-96. ISSN 0261-4189. PMID 11406595. doi:10.1093/emboj/20.12.3187.

[pmid8972232-6] Wang, L; Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis C D, Berger S L (Jan. de 1997). «Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation». Mol. Cell. Biol. (UNITED STATES) 17 (1): 519-27. ISSN 0270-7306. PMID 8972232.