MED6

Proteína mediadora de la transcripción de la subunidad 6 de la ARN polimerasa II
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	MED6 (HGNC: 19970) NY-REN-28
Identificadores; externos	OMIM: 602984 ; EBI: MED6; GeneCards: Gen MED6; UniProt: MED6;
Locus	Cr. 14 q24.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
10001
O75586	n/a
NP_005457	n/a

La proteína mediadora de la transcripción de la subunidad 6 de la ARN polimerasa II (MED6) es una enzima que, en humanos, es codificada por el gen med6.[1][2][3]

Interacciones

La proteína MED6 ha demostrado ser capaz de interaccionar con:

Referencias

Lee YC, Min S, Gim BS, Kim YJ (Aug de 1997). «A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans». Mol Cell Biol 17 (8): 4622-32. PMC 232315. PMID 9234719.
Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD (Aug de 1998). «Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways». Proc Natl Acad Sci U S A 95 (15): 8538-43. PMC 21111. PMID 9671713.
«Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)».
Ito, M; Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G (Mar. de 1999). «Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators». Mol. Cell (UNITED STATES) 3 (3): 361-70. ISSN 1097-2765. PMID 10198638.
Kang, Yun Kyoung; Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G (Mar. de 2002). «The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642-7. ISSN 0027-8424. PMID 11867769. doi:10.1073/pnas.261715899.
Sun, X; Zhang Y; Cho H; Rickert P; Lees E; Lane W; Reinberg D (Aug. de 1998). «NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription». Mol. Cell (UNITED STATES) 2 (2): 213-22. ISSN 1097-2765. PMID 9734358.
Yang, Fajun; DeBeaumont Rosalie, Zhou Sharleen, Näär Anders M (Feb. de 2004). «The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator». Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (8): 2339-44. ISSN 0027-8424. PMID 14983011.
Wang, G; Cantin G T, Stevens J L, Berk A J (Jul. de 2001). «Characterization of mediator complexes from HeLa cell nuclear extract». Mol. Cell. Biol. (United States) 21 (14): 4604-13. ISSN 0270-7306. PMID 11416138. doi:10.1128/MCB.21.14.4604-4613.2001.

Enlaces externos

MeSH: MED6+protein,+human (en inglés)

Datos: Q18034944

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[pmid9234719-1] Lee YC, Min S, Gim BS, Kim YJ (Aug de 1997). «A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans». Mol Cell Biol 17 (8): 4622-32. PMC 232315. PMID 9234719.

[pmid9671713-2] Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD (Aug de 1998). «Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways». Proc Natl Acad Sci U S A 95 (15): 8538-43. PMC 21111. PMID 9671713.

[entrez-3] «Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)».

[pmid10198638-4] Ito, M; Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G (Mar. de 1999). «Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators». Mol. Cell (UNITED STATES) 3 (3): 361-70. ISSN 1097-2765. PMID 10198638.

[pmid11867769-5] Kang, Yun Kyoung; Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G (Mar. de 2002). «The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642-7. ISSN 0027-8424. PMID 11867769. doi:10.1073/pnas.261715899.

[pmid9734358-6] Sun, X; Zhang Y; Cho H; Rickert P; Lees E; Lane W; Reinberg D (Aug. de 1998). «NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription». Mol. Cell (UNITED STATES) 2 (2): 213-22. ISSN 1097-2765. PMID 9734358.

[pmid14983011-7] Yang, Fajun; DeBeaumont Rosalie, Zhou Sharleen, Näär Anders M (Feb. de 2004). «The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator». Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (8): 2339-44. ISSN 0027-8424. PMID 14983011.

[pmid11416138-8] Wang, G; Cantin G T, Stevens J L, Berk A J (Jul. de 2001). «Characterization of mediator complexes from HeLa cell nuclear extract». Mol. Cell. Biol. (United States) 21 (14): 4604-13. ISSN 0270-7306. PMID 11416138. doi:10.1128/MCB.21.14.4604-4613.2001.