Receptor de estrógeno alfa

El receptor de estrógeno alfa, también denominado ER-alfa o NR3A1 (de sus siglas en inglés "Nuclear receptor subfamily 3, group A, member 1"), es uno de los miembros de la familia de factores de transcripción de receptores nucleares, activado por una hormona sexual, el estrógeno, y codificado en humanos por el gen ESR1.[1][2][3]

Receptor de estrógeno alfa

Estructura tridimensional del receptor de estrógeno alfa.
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB

 Lista de códigos PDB
1a52
Identificadores
Símbolos ESR1 (HGNC: 3467) ER; DKFZp686N23123; ESR; ESRA; Era; NR3A1
Identificadores
externos
Locus Cr. 6 q24-q27
Ortólogos
Especies
Humano Ratón
Entrez
2099
UniProt
P03372 n/a
RefSeq
(ARNm)
NP_000116 n/a

Estructura

El receptor de estrógeno es un factor de transcripción activado por ligando compuesto de varios dominios implicados en la unión de la hormona, en la unión al ADN y en la activación de la transcripción.[4] Se han descrito hasta 5 variantes transcripcionales del gen ESR1 obtenidas mediante splicing alternativo, que dan lugar a 5 ARNms diferentes los cuales se diferencian en las regiones 5' no traducidas. Los receptores resultantes de estas variantes muestran menos variabilidad.[5][6]

Coactivadores

Los principales coactivadores del receptor de estrógeno alfa son los siguientes:

Interacciones

El receptor de estrógeno alfa ha demostrado ser capaz de interaccionar con:

Referencias
  1. «Entrez Gene: ESR1 estrogen receptor 1».
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  6. «Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)».
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Enlaces externos
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