Proteína del retinoblastoma-like 2

Proteína del retinoblastoma-like 2
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	RBL2 (HGNC: 9894) FLJ26459; P130; Rb2
Identificadores; externos	OMIM: 180203 ; EBI: RBL2; GeneCards: Gen RBL2; UniProt: RBL2;
Locus	Cr. 16 q12.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
5934
Q08999	n/a
NP_005602	n/a

La proteína del retinoblastoma-like 2 (p130) es un factor de transcripción codificado en humanos por el gen rbl2.[1][2] Esta proteína pertenece a la familia de proteínas bolsillo.

Interacciones

La proteína del retinoblastoma-like 2 ha demostrado ser capaz de interaccionar con:

Véase también

Familia de proteínas pocket

Referencias

Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (Sep de 1993). «Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain». Oncogene 8 (9): 2561-6. PMID 8361765.
Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (Jul de 1996). «Genomic structure of the human retinoblastoma-related Rb2/p130 gene». Proc Natl Acad Sci U S A 93 (10): 4629-32. PMC 39329. PMID 8643454.
Ferreira, R; Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep. de 1998). «The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493-8. ISSN 0027-8424. PMID 9724731.
Bouzahzah, B; Fu M, Iavarone A, Factor V M, Thorgeirsson S S, Pestell R G (Aug. de 2000). «Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo». Cancer Res. (UNITED STATES) 60 (16): 4531-7. ISSN 0008-5472. PMID 10969803.
Wang, S; Ghosh R N, Chellappan S P (Dec. de 1998). «Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation». Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487-98. ISSN 0270-7306. PMID 9819434.
Meloni, A R; Smith E J, Nevins J R (Aug. de 1999). «A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574-9. ISSN 0027-8424. PMID 10449734.
Fusco, C; Reymond A, Zervos A S (Aug. de 1998). «Molecular cloning and characterization of a novel retinoblastoma-binding protein». Genomics (UNITED STATES) 51 (3): 351-8. ISSN 0888-7543. PMID 9721205. doi:10.1006/geno.1998.5368.
Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (Feb. de 1999). «Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest». Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460-9. ISSN 0270-7306. PMID 9891079.
Li, Y; Graham C, Lacy S, Duncan A M, Whyte P (Dec. de 1993). «The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E». Genes Dev. (UNITED STATES) 7 (12A): 2366-77. ISSN 0890-9369. PMID 8253383.
Wang, S; Nath N; Adlam M; Chellappan S (Jun. de 1999). «Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function». Oncogene (ENGLAND) 18 (23): 3501-10. ISSN 0950-9232. PMID 10376528. doi:10.1038/sj.onc.1202684.
Lacy, S; Whyte P (mayo. de 1997). «Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes». Oncogene (ENGLAND) 14 (20): 2395-406. ISSN 0950-9232. PMID 9188854. doi:10.1038/sj.onc.1201085.
Sutcliffe, J E; Cairns C A, McLees A, Allison S J, Tosh K, White R J (Jun. de 1999). «RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130». Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255-61. ISSN 0270-7306. PMID 10330166.
Fan, S; Yuan R, Ma Y X, Xiong J, Meng Q, Erdos M, Zhao J N, Goldberg I D, Pestell R G, Rosen E M (Aug. de 2001). «Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding». Oncogene (England) 20 (35): 4827-41. ISSN 0950-9232. PMID 11521194. doi:10.1038/sj.onc.1204666.

Enlaces externos

MeSH: RBL2+protein,+human (en inglés)

Datos: Q18031061

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[pmid8361765-1] Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (Sep de 1993). «Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain». Oncogene 8 (9): 2561-6. PMID 8361765.

[pmid8643454-2] Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (Jul de 1996). «Genomic structure of the human retinoblastoma-related Rb2/p130 gene». Proc Natl Acad Sci U S A 93 (10): 4629-32. PMC 39329. PMID 8643454.

[pmid9724731-3] Ferreira, R; Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep. de 1998). «The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493-8. ISSN 0027-8424. PMID 9724731.

[pmid10969803-4] Bouzahzah, B; Fu M, Iavarone A, Factor V M, Thorgeirsson S S, Pestell R G (Aug. de 2000). «Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo». Cancer Res. (UNITED STATES) 60 (16): 4531-7. ISSN 0008-5472. PMID 10969803.

[pmid9819434-5] Wang, S; Ghosh R N, Chellappan S P (Dec. de 1998). «Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation». Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487-98. ISSN 0270-7306. PMID 9819434.

[pmid10449734-6] Meloni, A R; Smith E J, Nevins J R (Aug. de 1999). «A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574-9. ISSN 0027-8424. PMID 10449734.

[pmid9721205-7] Fusco, C; Reymond A, Zervos A S (Aug. de 1998). «Molecular cloning and characterization of a novel retinoblastoma-binding protein». Genomics (UNITED STATES) 51 (3): 351-8. ISSN 0888-7543. PMID 9721205. doi:10.1006/geno.1998.5368.

[pmid9891079-8] Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (Feb. de 1999). «Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest». Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460-9. ISSN 0270-7306. PMID 9891079.

[pmid8253383-9] Li, Y; Graham C, Lacy S, Duncan A M, Whyte P (Dec. de 1993). «The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E». Genes Dev. (UNITED STATES) 7 (12A): 2366-77. ISSN 0890-9369. PMID 8253383.

[pmid10376528-10] Wang, S; Nath N; Adlam M; Chellappan S (Jun. de 1999). «Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function». Oncogene (ENGLAND) 18 (23): 3501-10. ISSN 0950-9232. PMID 10376528. doi:10.1038/sj.onc.1202684.

[pmid9188854-11] Lacy, S; Whyte P (mayo. de 1997). «Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes». Oncogene (ENGLAND) 14 (20): 2395-406. ISSN 0950-9232. PMID 9188854. doi:10.1038/sj.onc.1201085.

[pmid10330166-12] Sutcliffe, J E; Cairns C A, McLees A, Allison S J, Tosh K, White R J (Jun. de 1999). «RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130». Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255-61. ISSN 0270-7306. PMID 10330166.

[pmid11521194-13] Fan, S; Yuan R, Ma Y X, Xiong J, Meng Q, Erdos M, Zhao J N, Goldberg I D, Pestell R G, Rosen E M (Aug. de 2001). «Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding». Oncogene (England) 20 (35): 4827-41. ISSN 0950-9232. PMID 11521194. doi:10.1038/sj.onc.1204666.