Histona deacetilasa 1

La histona deacetilasa 1 (HDAC1) es una enzima codificada en humanos por el gen hdac1.[1]

Histona deacetilasa 1
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB

 Lista de códigos PDB
4BKX
 Estructuras enzimáticas
RCSB PDB, PDBe, PDBsum
Identificadores
Símbolos HDAC1 (HGNC: 4852) DKFZp686H12203; GON-10; HD1; RPD3; RPD3L1
Identificadores
externos
 Bases de datos de enzimas
IntEnz: entrada en IntEnz
BRENDA: entrada en BRENDA
ExPASy: NiceZime view
KEGG: entrada en KEEG
PRIAM: perfil PRIAM
ExplorEnz: entrada en ExplorEnz
MetaCyc: vía metabólica
Número EC 3.5.1.98
Locus Cr. 1 p35.1
Patrón de expresión de ARNm
ancho=250px
Más información
Ortólogos
Especies
Humano Ratón
Entrez
3065 433759
Ensembl
Véase HS Véase MM
UniProt
Q13547 O09106
RefSeq
(ARNm)
NM_004964 NM_008228
RefSeq
(proteína) NCBI
NP_004955 NP_032254
Ubicación (UCSC)
Cr. 1:
32.76 – 32.8 Mb 		Cr. 4:
129.52 – 129.54 Mb
PubMed (Búsqueda)


Función

Las histonas juegan un papel crucial en la regulación de la transcripción, en la progresión del ciclo celular y en procesos de desarrollo. La acetilación/desacetilación de histonas altera la estructura del cromosoma, variando así la accesibilidad de los factores de transcripción al ADN. La HDAC1 pertenece a la familia de histona deacetilasas acuc/alfa y es uno de los componentes del complejo histona deacetilasa. Esta proteína interacciona con la proteína del retinoblastoma formando un complejo que es un elemento clave en el control de la proliferación celular y la diferenciación celular. Junto con la proteína 2 asociada a metástasis, deacetila a p53 y modula su acción sobre la proliferación celular y la apoptosis.[2]

Interacciones

La histona deacetilasa 1 ha demostrado ser capaz de interaccionar con:

Véase también

Referencias
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