IKZF1

Proteína de unión a ADN Ikaros
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	IKZF1 (HGNC: 13176) IK1; Hs.54452; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk-1
Identificadores; externos	OMIM: 603023 ; EBI: IKZF1; GeneCards: Gen IKZF1; UniProt: IKZF1;
Locus	Cr. 7 p12.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
10320
Q13422	n/a
NP_006051	n/a

La proteína de unión a ADN Ikaros (IKZF1) es una proteína codificada en humanos por el gen IKZF1.[1][2][3]

La proteína IKZF1 pertenece a la familia de proteínas con dedos de zinc.

Interacciones

La proteína IKZF1 ha demostrado ser capaz de interaccionar con:

Referencias

Georgopoulos K, Moore DD, Derfler B (Dec de 1992). «Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment». Science 258 (5083): 808-12. PMID 1439790.
Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST (Nov de 1994). «The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene». Mol Cell Biol 14 (11): 7111-23. PMC 359245. PMID 7935426.
«Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)».
Koipally, Joseph; Georgopoulos Katia (Aug. de 2002). «A molecular dissection of the repression circuitry of Ikaros». J. Biol. Chem. (United States) 277 (31): 27697-705. ISSN 0021-9258. PMID 12015313. doi:10.1074/jbc.M201694200.
Koipally, J; Renold A; Kim J; Georgopoulos K (Jun. de 1999). «Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes». EMBO J. (ENGLAND) 18 (11): 3090-100. ISSN 0261-4189. PMID 10357820. doi:10.1093/emboj/18.11.3090.
Koipally, Joseph; Georgopoulos Katia (Jun. de 2002). «Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression». J. Biol. Chem. (United States) 277 (26): 23143-9. ISSN 0021-9258. PMID 11959865. doi:10.1074/jbc.M202079200.
Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar. de 1999). «Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system». FEBS Lett. (NETHERLANDS) 447 (1): 76-80. ISSN 0014-5793. PMID 10218586.
Perdomo, J; Holmes M; Chong B; Crossley M (Dec. de 2000). «Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities». J. Biol. Chem. (UNITED STATES) 275 (49): 38347-54. ISSN 0021-9258. PMID 10978333. doi:10.1074/jbc.M005457200.
Koipally, J; Georgopoulos K (Jun. de 2000). «Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity». J. Biol. Chem. (UNITED STATES) 275 (26): 19594-602. ISSN 0021-9258. PMID 10766745. doi:10.1074/jbc.M000254200.

Enlaces externos

MeSH: IKZF1+protein,+human (en inglés)

Datos: Q18035293

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[pmid1439790-1] Georgopoulos K, Moore DD, Derfler B (Dec de 1992). «Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment». Science 258 (5083): 808-12. PMID 1439790.

[pmid7935426-2] Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST (Nov de 1994). «The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene». Mol Cell Biol 14 (11): 7111-23. PMC 359245. PMID 7935426.

[entrez-3] «Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)».

[pmid12015313-4] Koipally, Joseph; Georgopoulos Katia (Aug. de 2002). «A molecular dissection of the repression circuitry of Ikaros». J. Biol. Chem. (United States) 277 (31): 27697-705. ISSN 0021-9258. PMID 12015313. doi:10.1074/jbc.M201694200.

[pmid10357820-5] Koipally, J; Renold A; Kim J; Georgopoulos K (Jun. de 1999). «Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes». EMBO J. (ENGLAND) 18 (11): 3090-100. ISSN 0261-4189. PMID 10357820. doi:10.1093/emboj/18.11.3090.

[pmid11959865-6] Koipally, Joseph; Georgopoulos Katia (Jun. de 2002). «Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression». J. Biol. Chem. (United States) 277 (26): 23143-9. ISSN 0021-9258. PMID 11959865. doi:10.1074/jbc.M202079200.

[pmid10218586-7] Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar. de 1999). «Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system». FEBS Lett. (NETHERLANDS) 447 (1): 76-80. ISSN 0014-5793. PMID 10218586.

[pmid10978333-8] Perdomo, J; Holmes M; Chong B; Crossley M (Dec. de 2000). «Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities». J. Biol. Chem. (UNITED STATES) 275 (49): 38347-54. ISSN 0021-9258. PMID 10978333. doi:10.1074/jbc.M005457200.

[pmid10766745-9] Koipally, J; Georgopoulos K (Jun. de 2000). «Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity». J. Biol. Chem. (UNITED STATES) 275 (26): 19594-602. ISSN 0021-9258. PMID 10766745. doi:10.1074/jbc.M000254200.