YWHAQ

Proteína theta de activación de la tirosina 3-monooxigenasa/triptófano 5-monooxigenasa
	; Estructura tridimensional de la proteína YWHAQ.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 2btp
Identificadores
Símbolos	YWHAQ (HGNC: 12854) HS1; 14-3-3; 1C5
Identificadores; externos	OMIM: 609009 ; EBI: YWHAQ; GeneCards: Gen YWHAQ; UniProt: YWHAQ;
Locus	Cr. 2 p25.1
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
10971
P27348	n/a
NP_006817	n/a

La proteína theta de activación de la tirosina 3-monooxigenasa/triptófano 5-monooxigenasa, también denominada proteína theta 14-3-3 o YWHAQ, es una proteína codificada en humanos por el gen YWHAQ.[1]

La proteína YWHAQ pertenece a la familia de proteínas 14-3-3 que median en la transducción de señales por la unión a proteínas que contengan fosfoserina. Esta familia de proteínas está altamente conservada y puede encontrarse tanto en plantas como en mamíferos. Esta proteína presenta un 99% de identidad con sus ortólogos de rata y ratón. Este gen está hiper-expresado en pacientes con esclerosis lateral amiotrófica. Contiene en su extremo UTR 5' una secuencia repetida en tándem que es polimórfica. Sin embargo, no existe correlación entre el número de repeticiones y la gravedad de la enfermedad.[2]

Interacciones

La proteína YWHAQ ha demostrado ser capaz de interaccionar con:

MEF2D[3]
Proteína X asociada a Bcl-2[4]
CRTC2[5][6]
c-Raf[6][7][8][9]
Histona deacetilasa 5[10]
NRIP1[11]
Proteína quinasa Mζ[8]
UCP3[12]
PFKFB2[13]
Telomerasa transcriptasa inversa[14]
Promotor de muerte asociado a Bcl-2[15][16]
Cbl[17][9]
Proteína quinasa D1[18][19]

Referencias

Malaspina A, Kaushik N, de Belleroche J (Nov de 2000). «A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord». J Neurochem 75 (6): 2511-20. PMID 11080204.
«Entrez Gene: YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide».
Choi, S J; Park S Y, Han T H (Jul. de 2001). «14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation». Nucleic Acids Res. (England) 29 (13): 2836-42. PMID 11433030.
Nomura, Masaya; Shimizu Shigeomi, Sugiyama Tomoyasu, Narita Masashi, Ito Toshinori, Matsuda Hikaru, Tsujimoto Yoshihide (Jan. de 2003). «14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax». J. Biol. Chem. (United States) 278 (3): 2058-65. ISSN 0021-9258. PMID 12426317. doi:10.1074/jbc.M207880200.
Screaton, Robert A; Conkright Michael D, Katoh Yoshiko, Best Jennifer L, Canettieri Gianluca, Jeffries Shawn, Guzman Ernesto, Niessen Sherry, Yates John R, Takemori Hiroshi, Okamoto Mitsuhiro, Montminy Marc (Oct. de 2004). «The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector». Cell (United States) 119 (1): 61-74. ISSN 0092-8674. PMID 15454081. doi:10.1016/j.cell.2004.09.015.
Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3: 89. PMID 17353931. doi:10.1038/msb4100134.
Yeung, K; Janosch P, McFerran B, Rose D W, Mischak H, Sedivy J M, Kolch W (mayo. de 2000). «Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein». Mol. Cell. Biol. (UNITED STATES) 20 (9): 3079-85. ISSN 0270-7306. PMID 10757792.
Van Der Hoeven, P C; Van Der Wal J C, Ruurs P, Van Dijk M C, Van Blitterswijk J (Jan. de 2000). «14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation». Biochem. J. (ENGLAND). 345 Pt 2: 297-306. ISSN 0264-6021. PMID 10620507.
Liu, Y C; Elly C, Yoshida H, Bonnefoy-Berard N, Altman A (Jun. de 1996). «Activation-modulated association of 14-3-3 proteins with Cbl in T cells». J. Biol. Chem. (UNITED STATES) 271 (24): 14591-5. ISSN 0021-9258. PMID 8663231.
Vega, Rick B; Harrison Brooke C, Meadows Eric, Roberts Charles R, Papst Philip J, Olson Eric N, McKinsey Timothy A (Oct. de 2004). «Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5». Mol. Cell. Biol. (United States) 24 (19): 8374-85. ISSN 0270-7306. PMID 15367659. doi:10.1128/MCB.24.19.8374-8385.2004.
Zilliacus, J; Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson J A (Apr. de 2001). «Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140». Mol. Endocrinol. (United States) 15 (4): 501-11. ISSN 0888-8809. PMID 11266503.
Pierrat, B; Ito M; Hinz W; Simonen M; Erdmann D; Chiesi M; Heim J (mayo. de 2000). «Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family». Eur. J. Biochem. (GERMANY) 267 (9): 2680-7. ISSN 0014-2956. PMID 10785390.
Pozuelo Rubio, Mercedes; Peggie Mark, Wong Barry H C, Morrice Nick, MacKintosh Carol (Jul. de 2003). «14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase». EMBO J. (England) 22 (14): 3514-23. ISSN 0261-4189. PMID 12853467. doi:10.1093/emboj/cdg363.
Seimiya, H; Sawada H; Muramatsu Y; Shimizu M; Ohko K; Yamane K; Tsuruo T (Jun. de 2000). «Involvement of 14-3-3 proteins in nuclear localization of telomerase». EMBO J. (ENGLAND) 19 (11): 2652-61. ISSN 0261-4189. PMID 10835362. doi:10.1093/emboj/19.11.2652.
Chen, Lin; Willis Simon N, Wei Andrew, Smith Brian J, Fletcher Jamie I, Hinds Mark G, Colman Peter M, Day Catherine L, Adams Jerry M, Huang David C S (Feb. de 2005). «Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function». Mol. Cell (United States) 17 (3): 393-403. ISSN 1097-2765. PMID 15694340. doi:10.1016/j.molcel.2004.12.030.
Hsu, S Y; Kaipia A, Zhu L, Hsueh A J (Nov. de 1997). «Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11». Mol. Endocrinol. (UNITED STATES) 11 (12): 1858-67. ISSN 0888-8809. PMID 9369453.
Pedraza-Alva, G; Sawasdikosol S, Liu Y C, Mérida L B, Cruz-Muñoz M E, Oceguera-Yañez F, Burakoff S J, Rosenstein Y (Jan. de 2001). «Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells». J. Biol. Chem. (UNITED STATES) 276 (1): 729-37. ISSN 0021-9258. PMID 11024037. doi:10.1074/jbc.M008494200.
Storz, P; Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K, Johannes F J (Aug. de 2000). «Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32». J. Biol. Chem. (UNITED STATES) 275 (32): 24601-7. ISSN 0021-9258. PMID 10831594. doi:10.1074/jbc.M002964200.
Hausser, A; Storz P, Link G, Stoll H, Liu Y C, Altman A, Pfizenmaier K, Johannes F J (Apr. de 1999). «Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins». J. Biol. Chem. (UNITED STATES) 274 (14): 9258-64. ISSN 0021-9258. PMID 10092600.

Datos: Q18035991

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[pmid11080204-1] Malaspina A, Kaushik N, de Belleroche J (Nov de 2000). «A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord». J Neurochem 75 (6): 2511-20. PMID 11080204.

[2] «Entrez Gene: YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide».

[pmid11433030-3] Choi, S J; Park S Y, Han T H (Jul. de 2001). «14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation». Nucleic Acids Res. (England) 29 (13): 2836-42. PMID 11433030.

[pmid12426317-4] Nomura, Masaya; Shimizu Shigeomi, Sugiyama Tomoyasu, Narita Masashi, Ito Toshinori, Matsuda Hikaru, Tsujimoto Yoshihide (Jan. de 2003). «14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax». J. Biol. Chem. (United States) 278 (3): 2058-65. ISSN 0021-9258. PMID 12426317. doi:10.1074/jbc.M207880200.

[pmid15454081-5] Screaton, Robert A; Conkright Michael D, Katoh Yoshiko, Best Jennifer L, Canettieri Gianluca, Jeffries Shawn, Guzman Ernesto, Niessen Sherry, Yates John R, Takemori Hiroshi, Okamoto Mitsuhiro, Montminy Marc (Oct. de 2004). «The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector». Cell (United States) 119 (1): 61-74. ISSN 0092-8674. PMID 15454081. doi:10.1016/j.cell.2004.09.015.

[pmid17353931-6] Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3: 89. PMID 17353931. doi:10.1038/msb4100134.

[pmid10757792-7] Yeung, K; Janosch P, McFerran B, Rose D W, Mischak H, Sedivy J M, Kolch W (mayo. de 2000). «Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein». Mol. Cell. Biol. (UNITED STATES) 20 (9): 3079-85. ISSN 0270-7306. PMID 10757792.

[pmid10620507-8] Van Der Hoeven, P C; Van Der Wal J C, Ruurs P, Van Dijk M C, Van Blitterswijk J (Jan. de 2000). «14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation». Biochem. J. (ENGLAND). 345 Pt 2: 297-306. ISSN 0264-6021. PMID 10620507.

[pmid8663231-9] Liu, Y C; Elly C, Yoshida H, Bonnefoy-Berard N, Altman A (Jun. de 1996). «Activation-modulated association of 14-3-3 proteins with Cbl in T cells». J. Biol. Chem. (UNITED STATES) 271 (24): 14591-5. ISSN 0021-9258. PMID 8663231.

[pmid15367659-10] Vega, Rick B; Harrison Brooke C, Meadows Eric, Roberts Charles R, Papst Philip J, Olson Eric N, McKinsey Timothy A (Oct. de 2004). «Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5». Mol. Cell. Biol. (United States) 24 (19): 8374-85. ISSN 0270-7306. PMID 15367659. doi:10.1128/MCB.24.19.8374-8385.2004.

[pmid11266503-11] Zilliacus, J; Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson J A (Apr. de 2001). «Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140». Mol. Endocrinol. (United States) 15 (4): 501-11. ISSN 0888-8809. PMID 11266503.

[pmid10785390-12] Pierrat, B; Ito M; Hinz W; Simonen M; Erdmann D; Chiesi M; Heim J (mayo. de 2000). «Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family». Eur. J. Biochem. (GERMANY) 267 (9): 2680-7. ISSN 0014-2956. PMID 10785390.

[pmid12853467-13] Pozuelo Rubio, Mercedes; Peggie Mark, Wong Barry H C, Morrice Nick, MacKintosh Carol (Jul. de 2003). «14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase». EMBO J. (England) 22 (14): 3514-23. ISSN 0261-4189. PMID 12853467. doi:10.1093/emboj/cdg363.

[pmid10835362-14] Seimiya, H; Sawada H; Muramatsu Y; Shimizu M; Ohko K; Yamane K; Tsuruo T (Jun. de 2000). «Involvement of 14-3-3 proteins in nuclear localization of telomerase». EMBO J. (ENGLAND) 19 (11): 2652-61. ISSN 0261-4189. PMID 10835362. doi:10.1093/emboj/19.11.2652.

[pmid15694340-15] Chen, Lin; Willis Simon N, Wei Andrew, Smith Brian J, Fletcher Jamie I, Hinds Mark G, Colman Peter M, Day Catherine L, Adams Jerry M, Huang David C S (Feb. de 2005). «Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function». Mol. Cell (United States) 17 (3): 393-403. ISSN 1097-2765. PMID 15694340. doi:10.1016/j.molcel.2004.12.030.

[pmid9369453-16] Hsu, S Y; Kaipia A, Zhu L, Hsueh A J (Nov. de 1997). «Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11». Mol. Endocrinol. (UNITED STATES) 11 (12): 1858-67. ISSN 0888-8809. PMID 9369453.

[pmid11024037-17] Pedraza-Alva, G; Sawasdikosol S, Liu Y C, Mérida L B, Cruz-Muñoz M E, Oceguera-Yañez F, Burakoff S J, Rosenstein Y (Jan. de 2001). «Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells». J. Biol. Chem. (UNITED STATES) 276 (1): 729-37. ISSN 0021-9258. PMID 11024037. doi:10.1074/jbc.M008494200.

[pmid10831594-18] Storz, P; Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K, Johannes F J (Aug. de 2000). «Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32». J. Biol. Chem. (UNITED STATES) 275 (32): 24601-7. ISSN 0021-9258. PMID 10831594. doi:10.1074/jbc.M002964200.

[pmid10092600-19] Hausser, A; Storz P, Link G, Stoll H, Liu Y C, Altman A, Pfizenmaier K, Johannes F J (Apr. de 1999). «Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins». J. Biol. Chem. (UNITED STATES) 274 (14): 9258-64. ISSN 0021-9258. PMID 10092600.