Examples of metabolic acidosis in the following topics:
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- Acid-base imbalances, including metabolic acidosis and alkalosis, can produce severe, even life-threatening medical conditions.
- The process that causes the imbalance is classified based on the etiology of the disturbance (respiratory or metabolic) and the direction of change in pH (acidosis or alkalosis).
- The phrase mixed acidosis, for example, refers to metabolic acidosis in conjunction with respiratory acidosis.
- In medicine, metabolic acidosis is a condition that occurs when the body produces too much acid or when the kidneys are not removing enough acid from the body.
- Differentiate among the acid-base disorders: metabolic acidosis, metabolic alkalosis, respiratory acidosis, and respiratory alkalosis
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- Acid-base imbalances, including metabolic acidosis and alkalosis, can produce severe, even life-threatening medical conditions.
- The process that causes the imbalance is classified based on the etiology of the disturbance (respiratory or metabolic) and the direction of change in pH (acidosis or alkalosis).
- The phrase "mixed acidosis," for example, refers to metabolic acidosis in conjunction with respiratory acidosis.
- In medicine, metabolic acidosis is a condition that occurs when the body produces too much acid or when the kidneys are not removing enough acid from the body.
- Metabolic alkalosis is a metabolic condition in which the pH of tissue is elevated beyond the normal range (7.35-7.45 ).
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- Metabolic acidosis may result from increased production of metabolic acids or disturbances in the ability to excrete acid via the kidneys.
- Renal acidosis is associated with an accumulation of urea and creatinine as well as metabolic acid residues of protein catabolism.
- Metabolic acidosis is compensated for in the lungs, as increased exhalation of carbon dioxide promptly shifts the buffering equation to reduce metabolic acid.
- Treatment of uncompensated metabolic acidosis is focused upon correcting the underlying problem.
- When metabolic acidosis is severe and can no longer be compensated for adequately by the lungs, neutralizing the acidosis with infusions of bicarbonate may be required.
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- The process that causes the imbalance is classified based on the etiology of the disturbance (respiratory or metabolic) and the direction of change in pH (acidosis or alkalosis).
- There are four basic processes: metabolic acidosis, respiratory acidosis, metabolic alkalosis, and respiratory alkalosis.
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- Since oxygen is not abundant, the Kreb's cycle is slowed resulting in lactic acidosis (the accumulation of lactate).
- The compensatory stage is characterized by the body employing physiological mechanisms, including neural, hormonal, and bio-chemical mechanisms in an attempt to reverse the lactic acidosis.
- As anaerobic metabolism continues, increasing the body's metabolic acidosis, the arteriolar smooth muscle and precapillary sphincters relax such that blood remains in the capillaries and will lead to leakage of fluid and protein into the surrounding tissues.
- The scheme depicts the cell metabolic response as a result of inadequate blood delivery during circulatory shock.
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- The opposite condition is acidosis (when pH falls below 7.35).
- Alkalosis can refer to respiratory alkalosis or metabolic alkalosis.
- Metabolic alkalosis is a metabolic condition in which the pH of tissue is elevated beyond the normal range (7.35-7.45 ).
- Compensatory mechanism for metabolic alkalosis involves slowed breathing by the lungs to increase serum carbon dioxide, a condition leaning toward respiratory acidosis.
- As respiratory acidosis often accompanies the compensation for metabolic alkalosis, and vice versa, a delicate balance is created between these two conditions.
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- Vomiting, diarrhea, and metabolic acidosis can also lead to hypochloremia.
- Bicarbonate ions result from a chemical reaction that starts with carbon dioxide (CO2) and water - two molecules that are produced at the end of aerobic metabolism.
- Bicarbonate is transported in the blood, and once in the lungs, the reactions reverse direction, and CO2 is regenerated from bicarbonate to be exhaled as metabolic waste .
- The addition and removal of phosphate from proteins in all cells is a pivotal strategy in the regulation of metabolic processes.
- In the lungs, CO2 is produced from bicarbonate and removed as metabolic waste through the reverse reaction of the bicarbonate bidirectional equation.
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- The purpose of exhalation is to remove metabolic waste, primarily carbon dioxide from the body from gas exchange.
- Involuntary expiration is not under conscious control, and is an important component for metabolic function.
- Changes in breathing patterns may also occur for metabolic reasons, such as through increased breathing rate in people with acidosis from negative feedback.
- While these two structures are involved in neural respiratory control, they also have other metabolic regulatory functions for other body systems, such as the cardiovascular system.
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- In response to acidosis, tubular cells reabsorb more bicarbonate from the tubular fluid, collecting duct cells secrete more hydrogen and generate more bicarbonate, and ammoniagenesis leads to increased formation of the NH3 buffer.
- In response to alkalosis, the kidneys may excrete more bicarbonate by decreasing hydrogen ion secretion from the tubular epithelial cells, and lowering rates of glutamine metabolism and ammonium excretion.
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- In response to acidosis, tubular cells reabsorb more bicarbonate from the tubular fluid, collecting duct cells secrete more hydrogen and generate more bicarbonate, and ammoniagenesis leads to increased formation of the NH3 buffer.
- In responses to alkalosis, the kidneys may excrete more bicarbonate by decreasing hydrogen ion secretion from the tubular epithelial cells, and lowering rates of glutamine metabolism and ammonium excretion.