Registry of Toxic Effects of Chemical Substances (RTECS)
Acetaldehyde, chloro-
RTECS #
AB2450000CAS #
107-20-0Updated
September 201Molecular Weight
78.50Molecular Formula
C2H3ClOSynonyms
2-Chloro-1-ethanal2-Chloroacetaldehyde
2-Chloroethanal
Chloroacetaldehyde
Chloroacetaldehyde (ACGIH:OSHA)
Chloroacetaldehyde monomer
Monochloroacetaldehyde
RCRA waste number P023
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
DNA adduct | testis/salmon | 3 gm | CRNGDP 3,663,1982 |
DNA adduct | lymphocyte/mammal (species unspecified) | 200 mmol/L | CBINA8 22,211,1978 |
DNA adduct | /Escherichia coli | 50 mmol/L/30M | MUREAV 684,24,2010 |
DNA Damage | liver/rat | 47 mmol/L | TOLED5 42,183,1988 |
DNA Damage | lymphocyte/human | 100 µmol/L | EMMUEG 20,277,1992 |
DNA Damage | sperm/salmon | 20 mmol/L | CNREA8 48,4804,1988 |
DNA inhibition | intravenous/rat | 5 gm/kg | CBINA8 17,239,1977 |
DNA repair | /Bacillus subtilis | 100 mmol/L | 37ATAD -,155,1977 |
DNA repair | /Escherichia coli | 10 mg/plate | EVHPAZ 21,79,1977 |
mutation in mammalian somatic cells | lymphocyte/human | 16 µmol/L | CRNGDP 18,31,1997 |
mutation in mammalian somatic cells | lung/hamster | 6400 nmol/L | IJCNAW 16,639,1975 |
mutation in microorganisms | /Bacillus subtilis | 5 mmol/L (-enzymatic activation step) | MSERDS 5,131,1981 |
mutation in microorganisms | /Salmonella typhimurium | 400 µmol/L (+enzymatic activation step) | MUREAV 32,93,1975 |
mutation in microorganisms | /Escherichia coli | 1 mmol/L (-enzymatic activation step) | CBINA8 12,265,1976 |
mutation in microorganisms | /Other microorganisms | 250 µg/plate (-enzymatic activation step) | CBINA8 30,9,1980 |
mutation in microorganisms | /Other microorganisms | 1 mmol/L (-enzymatic activation step) | MUREAV 73,1,1980 |
mutation in microorganisms | /Saccharomyes cerevisiae | 3100 µmol/L (+enzymatic activation step) | CNREA8 37,253,1977 |
mutation in microorganisms | /Aspergillus nidulans | 30 mg/plate (-enzymatic activation step) | CBINA8 30,9,1980 |
mutation in microorganisms | /Schizosaccharomyces pombe | 6250 µmol/L (+enzymatic activation step) | CNREA8 37,253,1977 |
other mutation test systems | /Bacillus subtilis | 1 mole/L | 37ATAD -,155,1977 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | Lowest published lethal concentration: 400 ppm/30M | Eye: Other eye effects Behavioral: Hallucinations, distorted perceptions Lung, Thorax, or Respiration: Dyspnea | NTIS** OTS0536151 |
inhalation/rat | lethal concentration (50 percent kill): 650 mg/m3/1H | Vascular: BP elevation not characterized in autonomic section Lung, Thorax, or Respiration: Respiratory obstruction Lung, Thorax, or Respiration: Other changes | EPASR* 8EHQ-0387-0660 |
intraperitoneal/guinea pig | lethal dose (50 percent kill): 2523 µg/kg | JPMSAE 61,19,1972 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 7 mg/kg | JPMSAE 61,19,1972 | |
intraperitoneal/rabbit | lethal dose (50 percent kill): 5522 µg/kg | JPMSAE 61,19,1972 | |
intraperitoneal/rat | lethal dose (50 percent kill): 7 mg/kg | JPMSAE 61,19,1972 | |
oral/mouse | lethal dose (50 percent kill): 82 mg/kg | JPMSAE 61,19,1972 | |
oral/rat | lethal dose (50 percent kill): 89 mg/kg | JPMSAE 61,19,1972 | |
skin/rabbit | lethal dose (50 percent kill): 267 mg/kg | JPMSAE 61,19,1972 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | lowest published toxic dose: 113 mg/kg/30D- intermittent | Brain and Coverings: Changes in brain weight Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JPMSAE 61,19,1972 |
parenteral/rat | lowest published toxic dose: 58 mg/kg/12W- intermittent | Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Blood: Changes in erythrocyte (RBC) count Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JPMSAE 61,19,1972 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 1 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | MUREAV 636,178,2007 | |
TOXICOLOGY REVIEW | MUREAV 727,1,2011 | |
TOXICOLOGY REVIEW | MUREAV 727,42,2011 | |
TOXICOLOGY REVIEW | TXCYAC 286,1,2011 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 1 ppm (3 mg/m3) | DTLVS* 3,48,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 1 ppm (3 mg/m3), JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | ceiling concentration 1 ppm (3.2 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 1 ppm (3 mg/m3);KZW 1 ppm (3 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | short term exposure limit 1 ppm (3.2 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | ceiling concentration 1 ppm (3 mg/m3), carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | short term exposure limit 1 ppm (3.3 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VLE 1 ppm (3 mg/m3), C3 Carcinogen, FEB2006 | |
Occupational Exposure Limit-ICELAND | short term exposure limit 1 ppm (3 mg/m3), NOV2011 | |
Occupational Exposure Limit-KOREA | ceiling concentration 1 ppm (3 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | peak 1 ppm (3 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 1 ppm (3.2 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (3 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | short term exposure limit 1 ppm (3.2 mg/m3), JUL2005 | |
Occupational Exposure Limit-SWITZERLAND | ceiling concentration 1 ppm (3 mg/m3), carc 3, JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 1 ppm (3 mg/m3), JAN1993 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-C 3 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1 ppm (3 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 1 ppm (3 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | short term exposure limit 1 ppm (3.3 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 1 ppm (3 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 1 ppm (3 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 1 ppm (3 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 1 ppm (3 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROACETALDEHYDE-air | ceiling concentration 1 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 | Hazard Code 18065; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 3; Total Number of Employees Exposed 788 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division