Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Acetone

RTECS #

AL3150000

CAS #

67-64-1

Updated

September 201

Molecular Weight

58.09

Molecular Formula

C3H6O

Synonyms

2-Propanone
Aceton (German, Dutch, Polish)
Acetone (ACGIH:OSHA)
beta-Ketopropane
Chevron acetone
Dimethyl ketone
Dimethylformaldehyde
Dimethylketal
Ketone propane
Ketone, dimethyl
Methyl ketone
Propanone
Pyroacetic acid
Pyroacetic ether
RCRA waste number U002

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 500 ppmJIHTAB 25,282,1943
eye /human 186300 ppm mildCRTXB2 32,43,2002
eye /rabbit 20 mg severeENTOX* -,27,2005
eye /rabbit 20 mg/24H moderate85JCAE -,280,1986
eye /rabbit 10 µL mildJTPAE7 29,187,2001
skin /rabbit 395 mg open irritation test mildUCDS** 5/7/1970
skin /rabbit 500 mg/24H mild85JCAE -,280,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisfibroblast/hamster40 gm/LFCTOD7 22,623,1984
sex chromosome loss and nondisjunctioninhalation/mouse12 gm/LVCVGK* -,409,1994
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae47600 ppmANYAA9 407,186,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) 31500 µg/m3/24H (1-13D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)GTPZAB 26(6),24,1982
inhalation/rat 30 mg/m3 (1-13D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death		VCVGK* -,409,1994
inhalation/rat 11000 ppm (6-19D pregnant)Reproductive: Other developmental abnormalitiesNTIS** #DE89-005671
inhalation/mouse 6600 ppm (6-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)		NTIS** #DE89-005671
oral/rat 273 gm/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTIS** PB91-185975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 355 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 620 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.024 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
inhalation/cat lowest published toxic concentration: 8000 mg/m3Eye: Conjunctiva irritation

Behavioral: Sleep		VCVGK* -,408,1984
inhalation/guinea pig lowest published toxic concentration: 72000 mg/m3/2HBehavioral: Alteration of classical conditioningVCVGK* -,408,1984
inhalation/human lowest published toxic concentration: 12000 mg/m3/3MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		VCVGK* -,408,1984
inhalation/human lowest published toxic concentration: 10 mg/m3/6HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseVCVGK* -,408,1984
inhalation/human lowest published toxic concentration: 500 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes		JIHTAB 25,282,1943
inhalation/man lowest published toxic concentration: 12000 ppm/4HGastrointestinal: Nausea or vomiting

Behavioral: Muscle weakness		AOHYA3 16,73,1973
inhalation/man lowest published toxic concentration: 440 µg/m3/6MBrain and Coverings: Recordings from specific areas of CNSGISAAA 42(8),42,1977
inhalation/man lowest published toxic concentration: 10 mg/m3/6HBiochemical: Metabolism (intermediary): Other carbohydratesGISAAA 42(8),42,1977
inhalation/mouse lethal concentration (50 percent kill): 44 gm/m3/4HCUTOEX 1,47,1993
inhalation/mouse Lowest published lethal concentration: 150000 mg/m3VCVGK* -,408,1984
inhalation/mouse lowest published toxic concentration: 10000 ppm/6MLung, Thorax, or Respiration: Respiratory depressionTOLED5 9,137,1981
inhalation/mouse lowest published toxic concentration: 30000 mg/m3/2HBehavioral: Alteration of classical conditioningVCVGK* -,408,1984
inhalation/rabbit lowest published toxic concentration: 1250 mg/m3Behavioral: Alteration of classical conditioningVCVGK* -,408,1984
inhalation/rat lowest published toxic concentration: 30000 mg/m3/2HBehavioral: Alteration of classical conditioningVCVGK* -,408,1984
inhalation/rat lethal concentration (50 percent kill): 50100 mg/m3/8HAIHAAP 20,364,1959
inhalation/rat lethal concentration (50 percent kill): 50100 mg/m3ENTOX* -,27,2005
inhalation/rat lowest published toxic concentration: 20000 ppm/1HBehavioral: Change in motor activity (specific assay)PBBHAU 89,101,2008
intraperitoneal/Dog lowest published lethal dose: 8 gm/kgBehavioral: Coma

Gastrointestinal: Alteration in gastric secretion		AEXPBL 18,218,1884
intraperitoneal/mouse lethal dose (50 percent kill): 1297 mg/kgSCCUR* -,1,1961
intraperitoneal/rat lowest published lethal dose: 500 mg/kgBehavioral: General anesthetic

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Renal function tests depressed		JPPMAB 11,150,1959
intraperitoneal/rat lowest published toxic dose: 1452 mg/kgBehavioral: AnticonvulsantBJPCBM 158,872,2009
intravenous/mouse lowest published lethal dose: 4 gm/kgFAONAU 48A,86,1970
intravenous/rabbit lowest published lethal dose: 1576 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression		JPETAB 33,175,1928
intravenous/rat lethal dose (50 percent kill): 5500 mg/kgNPIRI* 1,1,1974
oral/Dog lowest published lethal dose: 8 gm/kgBehavioral: Ataxia

Behavioral: Coma

Musculoskeletal: Joints		AEXPBL 18,218,1884
oral/Dog lowest published lethal dose: 8000 mg/kgVCVGK* -,408,1984
oral/human lowest published lethal dose: 714 mg/kgVCVGK* -,409,1984
oral/mammal (species unspecified) lowest published toxic dose: 3.49 gm/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Effect on specific coenzyme: NAD, NADP		VCVGK* -,408,1984
oral/man lowest published toxic dose: 2857 mg/kgBehavioral: Coma

Kidney, Ureter, and Bladder: Other changes		34ZIAG -,64,1969
oral/man lowest published toxic dose: 2857 mg/kgBehavioral: Coma

Biochemical: Metabolism (intermediary): Other		DIAEAZ 15,810,1966
oral/mouse lethal dose (50 percent kill): 3 gm/kgPCJOAU 14,162,1980
oral/rabbit lethal dose (50 percent kill): 5340 mg/kgFAONAU 48A,86,1970
oral/rat lowest published toxic dose: 5 mL/kgOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)		TOXID9 60,404,2001
oral/rat lethal dose (50 percent kill): 5800 mg/kgENTOX* -,27,2005
oral/rat lethal dose (50 percent kill): 5800 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor		JTEHD6 15,609,1985
skin/guinea pig lethal dose (50 percent kill): >9400 µL/kgTXAPA9 7,559,1965
skin/rabbit lowest published lethal dose: 20 mL/kgUCDS** 5/7/1970
subcutaneous/Dog lowest published lethal dose: 5 gm/kgAEXPBL 18,218,1884
subcutaneous/guinea pig lowest published lethal dose: 5 gm/kgAGGHAR 5,1,1933
unreported route/man lowest published lethal dose: 1159 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 100 mg/m3/6H/5D- intermittentCardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		VCVGK* -,409,1994
inhalation/human lowest published toxic concentration: 440 mg/m3/3Y- intermittentBlood: Changes in erythrocyte (RBC) count

Blood: Granulocytopenia		VCVGK* -,410,1994
inhalation/mouse lowest published toxic concentration: 11000 ppm/12D- intermittentBehavioral: General anestheticNTIS** #DE89-005671
inhalation/rat lowest published toxic concentration: 206 mg/m3/21D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Reproductive: Other effects on female		GISAAA 4,12,1994
inhalation/rat lowest published toxic concentration: 11000 ppm/9D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #DE89-005671
inhalation/rat lowest published toxic concentration: 30 mg/m3/13D- intermittentBiochemical: Metabolism (intermediary): Lipids including transportVCVGK* -,409,1994
inhalation/rat lowest published toxic concentration: 5000 ppm/3D- intermittentBehavioral: Change in motor activity (specific assay)PBBHAU 89,101,2008
inhalation/rat lowest published toxic concentration: 2000 mg/m3/4H/45D- intermittentEndocrine: Change in gonadotropins

Endocrine: Evidence of thyroid hyperfunction

Biochemical: Metabolism (intermediary): Effect on Na-K pump		VCVGK* -,409,1994
inhalation/rat lowest published toxic concentration: 199 mg/m3/8H/45D- intermittentBehavioral: Alteration of classical conditioningVCVGK* -,409,1994
inhalation/rat lowest published toxic concentration: 19000 ppm/3H/8W- intermittentBrain and Coverings: Changes in brain weightTXAPA9 61,302,1981
inhalation/rat lowest published toxic concentration: 199 mg/m3/8H/45D- intermittentBehavioral: Muscle contraction or spasticityGISAAA 25(5),3,1960
oral/mouse lowest published toxic dose: 546 gm/kg/13W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight		NTPTR* NIH-91-3122
oral/mouse lowest published toxic dose: 2 mg/kg/5D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		LIFSAK 69,923,2001
oral/rat lowest published toxic dose: 273 gm/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia		NTPTR* NIH-91-3122
oral/rat lowest published toxic dose: 5 mg/kg/5D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		LIFSAK 69,923,2001
oral/rat lowest published toxic dose: 7 gm/kg/7D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)BCPCA6 67,875,2004
oral/rat lowest published toxic dose: 15 mL/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)		TOLED5 144,55,2003
oral/rat lowest published toxic dose: 8.75 mL/kg/7D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport		CBCPAI 128,503,2001
oral/rat lowest published toxic dose: 145600 mg/kg/13W- continuousKidney, Ureter, and Bladder: Other changes

Blood: Macrocytosis

Blood: Other hemolysis with or without anemia		TOXID9 60,432,2001
skin/mouse lowest published toxic dose: 31.6 µg/kg/2W- intermittentBiochemical: Metabolism (intermediary): OtherMOCAE8 44,122,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 500 ppm;short term exposure limit 750 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 127,111,2002
TOXICOLOGY REVIEWCRTXB2 32,43,2002
TOXICOLOGY REVIEWMUREAV 566,209,2004
TOXICOLOGY REVIEWCHHSA* 9,6,2002
TOXICOLOGY REVIEWENTOX* -,27,2005
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWMUREAV 659,93,2008
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWMUREAV 674,62,2009
TOXICOLOGY REVIEWNCLNA* 16,503,1998
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWNTAPM* -,727,1995

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,289,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (2400 mg/m3)DTLVS* 3,3,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 500 ppm (1185 mg/m3), short term exposure limit 1000 ppm (2375 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 500 ppm (1200 mg/m3);KZW 2000 ppm (4800 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 500 ppm (1210 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 1000 ppm (2420 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 250 ppm (600 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 1210 mg/m3 (500 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 500 ppm (1200 mg/m3), short term exposure limit 630 ppm (1500 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 500 ppm (1210 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 500 ppm (1200 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1210 mg/m3, short term exposure limit 2420 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 250 ppm (600 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 200 ppm (470 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 750 ppm (1780 mg/m3), short term exposure limit 1000 ppm (2375 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (2400 mg/m3);short term exposure limit 1260 ppm(3000 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 500 ppm (1.185 mg/m3); short term exposure limit 1 ppm (2.375 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 125 ppm (295 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 500 ppm (1187 mg/m3); short term exposure limit 750 ppm (1781 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 600 mg/m3, MAC(short term exposure limit) 1800 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 200 mg/m3, short term exposure limit 800 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 250 ppm (600 mg/m3);short term exposure limit 500 ppm (1200 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 500 ppm (1200 mg/m3), KZG-week 1000 ppm (2400 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1780 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (2400 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (2400 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 500 ppm (1210 mg/m3);short term exposure limit 1500 ppm, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (2400 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (2400 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (2400 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (2400 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETONE-air10H time-weighted average 250 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 02820; Number of Industries 358; Total Number of Facilities 97342; Number of Occupations 215; Total Number of Employees Exposed 1740164; Total Number of Female Employees Exposed 540313
National Occupational Hazard Survey 1974Hazard Code 02820; Number of Industries 350; Total Number of Facilities 99713; Number of Occupations 188; Total Number of Employees Exposed 1287794

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100095/AS)
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-mouse embryo
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-03, October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-69

Follow NIOSH

NIOSH Homepage

TOP