Registry of Toxic Effects of Chemical Substances (RTECS)
Acetophenone, 2-chloro-
RTECS #
AM6300000CAS #
532-27-4Updated
September 201Molecular Weight
154.60Molecular Formula
C8H7ClOSynonyms
1-Chloroacetophenone2-Chloro-1-phenylethanone
2-Chloroacetophenone
alpha-Chloroacetophenone
alpha-Chloroacetophenone (ACGIH:OSHA)
Chemical mace
Chloromethyl phenyl ketone
CN
Ethanone, 2-chloro-1-phenyl-
Mace (lacrimator)
NCI-C55107
omega-Chloroacetophenone
Phenacyl chloride
Phenylchloromethylketone
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 1 mg | mild | TXAPA9 17,295,1970 |
eye /rabbit | 3 mg | severe | TXAPA9 17,295,1970 |
eye /rabbit | 2% rinse | mild | ARTODN 34,183,1975 |
eye /rabbit | 1% | VCVGK* -,463,1994 | |
skin /guinea pig | 12%/6H open irritation test | moderate | ARTODN 40,75,1978 |
skin /human | 0.5 mg/1H | moderate | CODEDG 86,150,1972 |
skin /rabbit | 5 mg/24H | mild | TXAPA9 17,295,1970 |
skin /rabbit | 12%/6H open irritation test | moderate | ARTODN 40,75,1978 |
skin /rat | 12%/6H open irritation test | moderate | ARTODN 40,75,1978 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | ovary/hamster | 3 mg/L | NTPTR* NTP-TR-379,1990 |
DNA Damage | liver/rat | 10 µmol/L | MUREAV 368,59,1996 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 2 mg/m3/6H/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Tumors Skin and Appendages: Tumors | NTPTR* NTP-TR-379,1990 |
skin/mouse | lowest published toxic dose: 2400 mg/kg/27W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application | BJCAAI 7,482,1953 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye/rabbit | lowest published toxic dose: 5 pph | Eye: Corneal damage | VCVGK* -,463,1994 |
inhalation/guinea pig | Lowest published lethal concentration: 490 mg/m3/30M | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
inhalation/human | Lowest published lethal concentration: 159 mg/m3/20M | 34ZIAG -,163,1969 | |
inhalation/human | lowest published toxic concentration: 93 mg/m3/3M | Eye: Lacrimation Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Dyspnea | AIHAAP 23,199,1962 |
inhalation/human | lowest published toxic concentration: 20 mg/m3 | Eye: Other eye effects Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea | BJIMAG 29,298,1972 |
inhalation/human | lowest published toxic concentration: 0.05 mg/m3/10S | Eye: Conjunctiva irritation | VCVGK* -,463,1994 |
inhalation/mouse | lethal concentration (50 percent kill): 59 mg/m3 | GISAAA 58(10),4,1993 | |
inhalation/rabbit | Lowest published lethal concentration: 465 mg/m3/20M | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
inhalation/rat | Lowest published lethal concentration: 417 mg/m3/15M | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
intraperitoneal/guinea pig | lethal dose (50 percent kill): 17 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
intraperitoneal/mouse | lethal dose (50 percent kill): 60 mg/kg | NTIS** AD837-111 | |
intraperitoneal/rat | lethal dose (50 percent kill): 36 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
intravenous/mouse | lethal dose (50 percent kill): 81 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Other changes | ARTODN 40,75,1978 |
intravenous/mouse | lethal dose (50 percent kill): 81 mg/kg | ENTOX* ,706,2005 | |
intravenous/rabbit | lethal dose (50 percent kill): 30 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Other changes | ARTODN 40,75,1978 |
intravenous/rat | lethal dose (50 percent kill): 41 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Other changes | ARTODN 40,75,1978 |
oral/guinea pig | lethal dose (50 percent kill): 158 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
oral/mouse | lethal dose (50 percent kill): 139 mg/kg | NTIS** AD837-111 | |
oral/rabbit | lethal dose (50 percent kill): 118 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
oral/rat | lethal dose (50 percent kill): 50 mg/kg | TXAPA9 17,295,1970 | |
skin/guinea pig | lethal dose (50 percent kill): >1 gm/kg | NTIS** OTS0556684 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 10 mg/m3/6H/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-379,1990 |
inhalation/mouse | lowest published toxic concentration: 87.6 mg/m3/15M/5D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Lung, Thorax, or Respiration: Other changes Endocrine: Hyperglycemia | JAPTO* 14,411,1994 |
inhalation/rat | lowest published toxic concentration: 19 mg/m3/6H/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-379,1990 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.05 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | CPEMM* 3,239,2002 | |
TOXICOLOGY REVIEW | ENTOX* -,626,2005 | |
TOXICOLOGY REVIEW | ENTOX* -,706,2005 | |
TOXICOLOGY REVIEW | HTCWA* 2,153, | |
TOXICOLOGY REVIEW | CCACL* 21,719,2005 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.05 ppm (0.3 mg/m3) | DTLVS* 3,48,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.05 ppm (0.32 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.04 ppm (0.3 mg/m3);KZW 0.08 ppm (0.6 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.05 ppm (0.32 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.05 ppm (0.3 mg/m3), MAY2011 | |
Occupational Exposure Limit-FINLAND | short term exposure limit 0.05 ppm (0.32 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.05 ppm (0.3 mg/m3), FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.05 ppm (0.3 mg/m3), NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.05 ppm (0.3 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.05 ppm (0.3 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.05 ppm (0.32 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.05 ppm (0.3 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 0.05 ppm (0.32 mg/m3), JUL2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.05 ppm (0.3 mg/m3), JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.3 mg/m3, 2003 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.05 ppm (0.32 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.05 ppm (0.3 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.05 ppm (0.3 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.05 ppm (0.3 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.05 ppm (0.3 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-CHLOROACETOPHENONE-air | 10H time-weighted average 0.05 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code X4754; Number of Industries 1; Total Number of Facilities 35; Number of Occupations 4; Total Number of Employees Exposed 2294; Total Number of Female Employees Exposed 1412 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division