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Registry of Toxic Effects of Chemical Substances (RTECS)

Acrylic acid

RTECS #

AS4375000

CAS #

79-10-7

Updated

September 201

Molecular Weight

72.07

Molecular Formula

C3H4O2

Synonyms

2-Propenoic acid (9CI)
Acroleic acid
Acrylic acid (ACGIH)
Acrylic acid, glacial
Ethylenecarboxylic acid
Glacial acrylic acid
Kyselina akrylova (Czech)
Propene acid
Propenoic acid
RCRA waste number U008
Vinylformic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1 mg severeUCDS** 2/2/1965
eye /rabbit 250 µg/24H severe85JCAE -,309,1986
skin /rabbit 500 mg open irritation test severeUCDS** 2/2/1965
skin /rabbit 5 mg/24H severe85JCAE -,309,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/mouse450 mg/LEMMUEG 11,49,1988
Cytogenetic Analysisovary/hamster116 mg/LFCTOD7 30,505,1992
mutation in mammalian somatic cellsother cell types/mouse4.56 mmol/l (+/-enzymatic activation step)HPV063 -,-,2003
mutation in mammalian somatic cellslymphocyte/mouse500 mg/LEMMUEG 11,49,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 300 ppm (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female		TOSCF2 48,240,1999
inhalation/rabbit 75 ppm (6-18D pregnant)Reproductive: Other effects on femaleHPV063 -,-,2003
intraperitoneal/rat 14340 µg/kg (5-15D pregnant)Reproductive: Other developmental abnormalitiesJDREAF 51,1632,1972
intraperitoneal/rat 7329 µg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		JDREAF 51,1632,1972
oral/rat 169 gm/kg (13W male/13W pre-3W after birth)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical		DCTODJ 6,1,1983
oral/rat 43680 mg/kg (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		NTIS** OTS0573007
oral/rat 16800 mg/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)HPV063 -,-,2003

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 37440 mg/kg/78W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia		EPASR* 8EHQ-0386-0592
skin/mouse toxic dose: 37440 mg/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors		EPASR* 8EHQ-0386-0592
subcutaneous/mouse lowest published toxic dose: 2912 mg/kg/52W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application		CBINA8 61,189,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 40 mg/m3Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes		TOVEFN (4),23,2000
inhalation/monkey Lethal concentration: >75 ppm/6HOlfaction: Deviated nasal septum

Olfaction: Ulcerated nasal septum		TOXID9 36(1 Pt2),113,1997
inhalation/mouse lethal concentration (50 percent kill): 5300 mg/m3/2H85GMAT -,16,1982
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HTXAPA9 28,313,1974
inhalation/rat Lowest published lethal concentration: 4105 mg/m3/1HLung, Thorax, or Respiration: DyspneaHPV063 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 144 mg/kgYKKZAJ 104,793,1984
intraperitoneal/rat lethal dose (50 percent kill): 22 mg/kgJDREAF 51,1632,1972
oral/mouse lethal dose (50 percent kill): 2400 mg/kgTumorigenic: Active as anti-cancer agentBIJOAK 34,1196,1940
oral/rat lethal dose (50 percent kill): 33500 µg/kg85GMAT -,16,1982
oral/rat lethal dose (50 percent kill): 1337 mg/kgBehavioral: Somnolence (general depressed activity)HPV063 -,-,2003
skin/rabbit lethal dose (50 percent kill): 280 µL/kgTXAPA9 28,313,1974
skin/rabbit lethal dose (50 percent kill): 640 mg/kgCardiac: Cardiomegaly

Lung, Thorax, or Respiration: Acute pulmonary edema

Skin: After topical application: Corrosive		HPV063 -,-,2003
subcutaneous/mouse lethal dose (50 percent kill): 1590 mg/kgJPPMAB 21,85,1969
unreported route/mouse lethal dose (50 percent kill): 830 mg/kgGISAAA 49(10),64,1984
unreported route/rabbit lethal dose (50 percent kill): 250 mg/kgGISAAA 49(10),64,1984
unreported route/rat lethal dose (50 percent kill): 1250 mg/kgGISAAA 49(10),64,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 223 ppm/6H/2W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FAATDF 1,271,1981
inhalation/mouse lowest published toxic concentration: 25 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FAATDF 1,271,1981
inhalation/mouse lowest published toxic concentration: 225 ppm/6H/10D- intermittentOlfaction: Other olfaction effects

Behavioral: Muscle contraction or spasticity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0555707
inhalation/mouse lowest published toxic concentration: 25 ppm/13W- intermittentOlfaction: Other olfaction effects

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV063 -,-,2003
inhalation/rat lowest published toxic concentration: 223 ppm/6H/2W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FAATDF 1,271,1981
inhalation/rat lowest published toxic concentration: 75 ppm/6H/13W- intermittentOlfaction: Other olfaction effectsFAATDF 1,271,1981
inhalation/rat lowest published toxic concentration: 225 ppm/6H/10D- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0555707
inhalation/rat lowest published toxic concentration: 75 ppm/13W- intermittentOlfaction: Other olfaction effectsHPV063 -,-,2003
oral/rat lowest published toxic dose: 22500 mg/kg/90D- continuousBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight		DCTODJ 6,1,1983
oral/rat lowest published toxic dose: 36000 mg/kg/48W- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV063 -,-,2003
oral/rat lowest published toxic dose: 21000 mg/kg/12W- intermittentBehavioral: Fluid intakeHPV063 -,-,2003
oral/rat lowest published toxic dose: 63000 mg/kg/12W- intermittentBrain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV063 -,-,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMEMDT 19,47,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMEMDT 71,1223,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 19,47,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1223,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1223,1999
TOXICOLOGY REVIEWENTOX* -,45,2005
TOXICOLOGY REVIEWNTAPM* -,727,1995

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (5.9 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (6 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (5.9 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (6 mg/m3), short term exposure limit 15 ppm (45 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (6 mg/m3), VLE 10 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (30 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (5.9 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (30 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (5.9 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (5.9 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 5 mg/m3, short term exposure limit 15 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (30 mg/m3);short term exposure limit 15 ppm (45 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 10 ppm (30 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5.9 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACRYLIC ACID-air10H time-weighted average 2 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 03570; Number of Industries 74; Total Number of Facilities 4826; Number of Occupations 67; Total Number of Employees Exposed 96535; Total Number of Female Employees Exposed 28146
National Occupational Hazard Survey 1974Hazard Code 03570; Number of Industries 44; Total Number of Facilities 1679; Number of Occupations 41; Total Number of Employees Exposed 28576

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8796
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #28

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