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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Anisidine

RTECS #

BZ5450000

CAS #

104-94-9

Updated

September 201

Molecular Weight

123.17

Molecular Formula

C7H9NO

Synonyms

1-Amino-4-methoxybenzene
4-Aminoanisole
4-Anisidine
4-Methoxy-1-aminobenzene
4-Methoxyaniline
4-Methoxybenzenamine
4-Methoxybenzeneamine
Aniline, p-methoxy-
Anisole, p-amino-
Benzenamine, 4-methoxy- (9CI)
p-Aminoanisole
p-Anisidine (ACGIH:OSHA)
p-Anisylamine
p-Methoxyaniline
p-Methoxyphenylamine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster160 mg/LEMMUEG 10(Suppl 10),1,1987
DNA Damagelymphocyte/mouse202 µmol/LMUREAV 203,155,1988
DNA Damageother cell types/mouse32 mg/L/24H (-enzymatic activation step)MUREAV 541,9,2003
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
DNA repair/Escherichia coli39 mmol/LMUREAV 272,145,1992
host-mediated assayEscherichia coli/mouse780 mg/kgMUREAV 272,161,1992
morphological transformembryo/hamster6.16 mg/L/7DMUTAEX 20,51,2005
mutation in mammalian somatic cellslymphocyte/mouse392 µmol/LMUTAEX 3,193,1988
mutation in microorganismslymphocyte/mouse196 µmol/L (+enzymatic activation step)MUTAEX 3,193,1988
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
sister chromatid exchangeovary/hamster14 mg/LEMMUEG 10(Suppl 10),1,1987
specific locus testAscites tumor/mouse32 mg/L/24HEMMUEG 42,91,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 806 mg/kgJMCMAR 17,900,1974
intraperitoneal/rat lethal dose (50 percent kill): 1400 mg/kgAGGHAR 15,447,1957
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTPKVAL 4,91,1962
oral/mouse lowest published lethal dose: 295.6 mg/kgCardiac: Other changes

Liver: Fatty liver degeneration

Liver: Other changes		TPKVAL 4,91,1962
oral/mouse lethal dose (50 percent kill): 1410 mg/kgEye: Other eye effects

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia		ATDAEI 1,184,1992
oral/rabbit lethal dose (50 percent kill): 2900 mg/kgKidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Other changes		IMEMDT 27,63,1982
oral/rat lethal dose (50 percent kill): 1320 mg/kgTLSMA6 128,14,1979
skin/rat lethal dose (50 percent kill): 3200 mg/kgAGGHAR 15,447,1957

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 10 mg/m3/4H/30D- intermittentBrain and Coverings: Changes in circulation

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi		TPKVAL 4,91,1962
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/244D- intermittentBlood: Normocytic anemiaTPKVAL 4,91,1962
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/335D- intermittentBlood: Changes in other cell count (unspecified)TPKVAL 4,91,1962
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/0.5Y- intermittentGastrointestinal: Ulceration or bleeding from small intestine

Endocrine: Changes in spleen weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TPKVAL 4,91,1962

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 27,63,1982
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 ppm (0.5 mg/m3) (skin)DTLWS* 3,10,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.5 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRIATRK-TMW 0.1 ppm (0.5 mg/m3);KZW 0.2 ppm (1 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.5 mg/m3), short term exposure limit 0.3 ppm (1.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.5 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 ppm (0.5 mg/m3), skin, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.5 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.5 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.1 ppm (0.5 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-ANISIDINE-air10H time-weighted average 0.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Anisidine, 2514

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