Registry of Toxic Effects of Chemical Substances (RTECS)
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Arsenic acid, calcium salt (2:3)
RTECS #
CG0830000CAS #
7778-44-1; 1333-25-1Updated
September 201Molecular Weight
398.08Molecular Formula
As2O8·3CaSynonyms
Arseniate de calcium (French)Calcium arsenate
Calcium orthoarsenate
Calciumarsenat
Chip-Cal granular
Cucumber dust
Fencal
Kalziumarseniat (German)
Kilmag
Pencal
Spra-cal
Tricalcium arsenate
Tricalciumarsenat (German)
Turf-cal
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intratracheal/hamster | lowest published toxic dose: 120 mg/kg/15W- continuous | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | CALEDQ 27,99,1985 |
| intratracheal/hamster | toxic dose: 214 mg/kg/15W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | IJCNAW 40,220,1987 |
| intratracheal/rat | lowest published toxic dose: 1600 µg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Tumors at site of application | IJCNAW 24,786,1979 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/Dog | lethal dose (50 percent kill): 38 mg/kg | 85DPAN -,-,1971/1976 | |
| oral/mouse | lethal dose (50 percent kill): 794 mg/kg | AMRL** TR-72-62,1972 | |
| oral/rabbit | lowest published lethal dose: 50 mg/kg | JPETAB 39,246,1930 | |
| oral/rat | lethal dose (50 percent kill): 20 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Dehydration | AFDOAQ 15,122,1951 |
| skin/rat | lethal dose (50 percent kill): 2400 mg/kg | 28ZEAL 5,35,1976 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published toxic dose: 24 gm/kg/2Y- continuous | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | PHRPA6 56,1610,1941 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.01 mg(As)/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Sufficient Evidence | IMEMDT 23,39,1980 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMSUDL 7,100,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 23,39,1980 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 1 | IMSUDL 7,100,1987 |
| TOXICOLOGY REVIEW | 85DHAX As,-,1977 | |
| TOXICOLOGY REVIEW | TOLED5 133,1,2002 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,160,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 mg(As)/m3 | DTLVS* 3,16,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1 mg/m3, MAY2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.2 mg(As)/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.2 mg(As)/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.01 mg(As)/m3, JAN1999 | |
| Occupational Exposure Limit-POLAND | time-weighted average 0.01 mg(As)/m3, JAN1999 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1 mg/m3, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1 mg/m3, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.1 mg(As)/m3, carc, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA)-cancer hazard | CFRGBR 29,1910.1018,1987 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air | Carcinogen ceiling concentration 0.002 mg(As)/m3/15M | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division