Registry of Toxic Effects of Chemical Substances (RTECS)
4-Biphenylamine
RTECS #
DU8925000CAS #
92-67-1Updated
September 201Molecular Weight
169.24Molecular Formula
C12H11NSynonyms
(1,1'-Biphenyl)-4-amine4-Aminobifenyl (Czech)
4-Aminobiphenyl
4-Aminodifenil (Spanish)
4-Aminodiphenyl
4-Aminodiphenyl (ACGIH:OSHA)
4-Bifenylamin (Czech)
Biphenylamine
p-Aminobiphenyl
p-Aminodiphenyl
Paraaminodiphenyl
p-Biphenylamine
p-Phenylaniline
Xenylamin (Czech)
Xenylamine
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
body fluid assay | Salmonella typhimurium/rat | 250 µmol/kg | TXCYAC 16,113,1980 |
body fluid assay | Salmonella typhimurium/Dog | 10 mg/kg | CNREA8 37,1757,1977 |
Cytogenetic Analysis | intraperitoneal/mouse | 25 mg/kg | MUREAV 268,255,1992 |
Cytogenetic Analysis | lymphocyte/mouse | 50 mg/L | MUREAV 320,69,1994 |
Cytogenetic Analysis | intraperitoneal/rat | 10 mg/kg/72H | NULSAK 23,36,1980 |
DNA adduct | /Escherichia coli | 30 µmol/L | MUREAV 89,95,1981 |
DNA adduct | oral/Dog | 5 mg/kg | CNREA8 48,6336,1988 |
DNA adduct | skin/mouse | 8.5 mg/kg/24H | TOXID9 72(Supp 1),336,2003 |
DNA adduct | oral/mouse | 80 mg/kg | TOSCF2 73,279,2003 |
DNA adduct | unreported route/mouse | 120 mg/kg | CBINA8 146,51,2003 |
DNA adduct | oral/rat | 10 mg/kg | TOXID9 90,161,2006 |
DNA adduct | skin/mouse | 10 mg/kg | JNCIEQ 95,1227,2003 |
DNA adduct | intraperitoneal/mouse | 558.492 µg/kg/8D- intermittent | MOCAE8 42,193,2005 |
DNA Damage | intraperitoneal/mouse | 1692.4 µg/kg/8D- intermittent | MOCAE8 42,193,2005 |
DNA Damage | other cell types/human | 0.06 mmol/plate | EMMUEG 38,1,2001 |
DNA Damage | other cell types/rat | 0.5 mmol/L/20H | TXCYAC 179,115,2002 |
DNA Damage | other cell types/human | 0.125 mmol/L/20H | TXCYAC 179,115,2002 |
DNA Damage | other cell types/human | 60 µmol/L | EMMUEG 38,1,2001 |
DNA Damage | lymphocyte/human | 500 µmol/L/2H | TOSCF2 72,283,2003 |
DNA Damage | lung/hamster | 300 µmol/L/2H | BBRCA9 72,732,1976 |
DNA Damage | liver/rat | 30 µmol/L | SinJF# 26OCT1982 |
DNA repair | /Bacillus subtilis | 200 µg/disc | MUREAV 97,1,1982 |
DNA repair | /Escherichia coli | 250 mg/L | JJIND8 62,873,1979 |
gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 2 pph | JJIND8 62,901,1979 |
host-mediated assay | Salmonella typhimurium/rat | 1 mmol/kg | MUREAV 93,317,1982 |
host-mediated assay | Escherichia coli/mouse | 67 mg/kg | MUREAV 272,161,1992 |
micronucleus test | intraperitoneal/mouse | 28 mg/kg/24H-continuous | MUREAV 216,321,1989 |
micronucleus test | oral/mouse | 50 mg/kg/48H- intermittent | MUREAV 389,3,1997 |
morphological transform | embryo/mouse | 10 mg/L | JNCIAM 52,1167,1974 |
morphological transform | oral/rat | 100 mg/kg | CNREA8 40,1157,1980 |
morphological transform | embryo/rat | 10 mg/L | JNCIAM 51,799,1973 |
morphological transform | kidney/hamster | 80 µg/L | BJCAAI 37,873,1978 |
morphological transform | embryo/hamster | 5 mg/L | NCIMAV 58,243,1981 |
morphological transform | fibroblast/mouse | 0.1 mg/L/21D (-enzymatic activation step) | EMMUEG 35,300,2000 |
mutation in mammalian somatic cells | lung/hamster | 5 mg/L | CNREA8 43,5194,1983 |
mutation in mammalian somatic cells | lymphocyte/mouse | 5 mg/L | MUREAV 125,291,1984 |
mutation in mammalian somatic cells | oral/mouse | 75 mg/kg | MUREAV 400,245,1998 |
mutation in mammalian somatic cells | fibroblast/human | 60 mg/L | MUREAV 121,71,1983 |
mutation in microorganisms | /Salmonella typhimurium | 2 µg/plate (-enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
mutation in microorganisms | /Escherichia coli | 900 µg/L (+enzymatic activation step) | CNREA8 39,682,1979 |
mutation in microorganisms | /Salmonella typhimurium | 3 µg/plate (+enzymatic activation step) | TOSCF2 56,351,2000 |
mutation in microorganisms | /Salmonella typhimurium | 10 µg/plate/20M (+enzymatic activation step) | MUREAV 515,15,2002 |
mutation in microorganisms | /Salmonella typhimurium | 1 nmol/plate/20M | EMMUEG 38,268,2001 |
mutation in microorganisms | /Salmonella typhimurium | 600 µmol/L/3H | TCMUD8 23,47,2003 |
mutation in microorganisms | /Escherichia coli | 30 nmol/plate (+enzymatic activation step) | MUTAEX 20,199,2005 |
mutation in microorganisms | /Escherichia coli | 37.5 nmol/plate/48H (+enzymatic activation step) | MUTAEX 20,199,2005 |
other mutation test systems | intraperitoneal/mouse | 100 mg/kg | MUREAV 268,255,1992 |
other mutation test systems | lymphocyte/mouse | 50 mg/L | MUREAV 320,69,1994 |
phage inhibition capacity | /Escherichia coli | 25 mg/L | CNREA8 41,532,1981 |
sister chromatid exchange | intraperitoneal/hamster | 50 mg/kg | MUREAV 113,33,1983 |
sister chromatid exchange | oral/hamster | 50 mg/kg | MUREAV 113,33,1983 |
specific locus test | oral/Drosophila melanogaster | 500 µmol/L | MUREAV 242,169,1990 |
specific locus test | intraperitoneal/mouse | 0.3 µmol/2D- intermittent | MUTAEX 21,29,2006 |
specific locus test | ovary/hamster | 5 mg/L/9D | EMMUEG 16,260,1990 |
Unscheduled DNA Synthesis | liver/human | 100 µg/L | MUREAV 206,91,1988 |
Unscheduled DNA Synthesis | fibroblast/human | 800 µg/L | TXCYAC 21,151,1981 |
Unscheduled DNA Synthesis | oral/mouse | 200 mg/kg | ENMUDM 6,474,1984 |
Unscheduled DNA Synthesis | liver/rabbit | 500 µmol/L | CNREA8 43,3120,1983 |
Unscheduled DNA Synthesis | oral/rat | 200 mg/kg | ENMUDM 6,474,1984 |
Unscheduled DNA Synthesis | liver/rat | 3 µmol/L | MUREAV 216,101,1989 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lowest published toxic dose: 85 µg/kg | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | CALEDQ 185,13,2002 |
oral/Dog | toxic dose: 5580 mg/kg/4Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Kidney, Ureter, and Bladder: Bladder tumors | NEOLA4 15,3,1968 |
oral/Dog | toxic dose: 8200 mg/kg/90W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | JAMAAP 172,1611,1960 |
oral/Dog | toxic dose: 8200 mg/kg/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | IMSUAI 27,25,1958 |
oral/Dog | toxic dose: 9600 mg/kg/3Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | IMSUAI 27,25,1958 |
oral/Dog | toxic dose: 8400 mg/kg/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | IMSUAI 27,25,1958 |
oral/Dog | toxic dose: 14 gm/kg/3Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | IMSUAI 27,25,1958 |
oral/mouse | toxic dose: 5460 µg/kg | Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors Blood: Tumors | EJCODS 21,865,1985 |
oral/mouse | lowest published toxic dose: 1520 mg/kg/39W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors | BJCAAI 19,297,1965 |
oral/rat | lowest published toxic dose: 5 gm/kg/52W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors | ARZNAD 12,270,1962 |
subcutaneous/mouse | lowest published toxic dose: 216 mg/kg/3D- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | JNCIAM 41,403,1968 |
subcutaneous/rat | toxic dose: 5000 mg/kg/1W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Liver: Tumors | BMBUAQ 14,141,1958 |
subcutaneous/rat | lowest published toxic dose: 4560 mg/kg/44W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Kidney tumors | NATUAS 175,1131,1955 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lowest published lethal dose: 250 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | CBCCT* 6,54,1954 |
intraperitoneal/rat | lowest published toxic dose: 10 µg/kg | Blood: Other changes | BECTA6 67,649,2001 |
oral/Dog | lowest published lethal dose: 25 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | SCIEAS 167,992,1970 |
oral/Dog | lethal dose (50 percent kill): 25 mg/kg | ENTOX* -,92,2005 | |
oral/mouse | lethal dose (50 percent kill): 205 mg/kg | EJCODS 21,865,1985 | |
oral/mouse | lowest published toxic dose: 120 mg/kg | Liver: Other changes | TOXID9 66,10,2002 |
oral/rabbit | lethal dose (50 percent kill): 690 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JIHTAB 29,1,1947 |
oral/rat | lethal dose (50 percent kill): 500 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JIHTAB 29,1,1947 |
oral/rat | lethal dose (50 percent kill): 500 mg/kg | ENTOX* -,92,2005 | |
oral/rat | lowest published toxic dose: 0.1 µg/kg | Blood: Other changes | BECTA6 67,649,2001 |
skin/mouse | lowest published toxic dose: 16.9 mg/kg | Liver: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TXAPA9 181,32,2002 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lowest published toxic dose: 16755 µg/kg/8D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | MOCAE8 42,193,2005 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Control as low as possible | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed human carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Limited Evidence | IMEMDT 1,74,1972 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 1,74,1972 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Sufficient Evidence | IMEMDT 28,151,1982 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 1 | IMSUDL 7,91,1987 |
TOXICOLOGY REVIEW | KHZHAZ 12(2),85,1976 | |
TOXICOLOGY REVIEW | ADCSAJ 13,271,1970 | |
TOXICOLOGY REVIEW | BLFSBY 24,253,1983 | |
TOXICOLOGY REVIEW | ARPTDI 43,485,2003 | |
TOXICOLOGY REVIEW | TOLED5 134,39,2002 | |
TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
TOXICOLOGY REVIEW | TXAPA9 197,144,2004 | |
TOXICOLOGY REVIEW | MUTAEX 14,301,1999 | |
TOXICOLOGY REVIEW | TCMUD8 23(Suppl 1),187,2003 | |
TOXICOLOGY REVIEW | MUREAV 588,88,2005 | |
TOXICOLOGY REVIEW | MUREAV 612,58,2006 | |
TOXICOLOGY REVIEW | MUREAV 567,427,2004 | |
TOXICOLOGY REVIEW | MUREAV 567,447,2004 | |
TOXICOLOGY REVIEW | ENTOX* -,92,2005 | |
TOXICOLOGY REVIEW | FCTOD7 44,1699,2006 | |
TOXICOLOGY REVIEW | MUREAV 627,10,2007 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | TOPADD 33,517,2005 | |
TOXICOLOGY REVIEW | MUREAV 659,68,2008 | |
TOXICOLOGY REVIEW | HUTOX* -,649,1996 | |
TOXICOLOGY REVIEW | MUREAV 574,92,2005 | |
TOXICOLOGY REVIEW | MUREAV 590,1,2005 | |
TOXICOLOGY REVIEW | MUTAEX 23,1,2008 | |
TOXICOLOGY REVIEW | MUREAV 579,6,2005 | |
TOXICOLOGY REVIEW | MUREAV 705,107,2010 | |
TOXICOLOGY REVIEW | MUREAV 751,49,2012 | |
TOXICOLOGY REVIEW | MUREAV 752,99,2013 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD | skin-HUMAN CARCINOGEN, NO ASSIGNED time-weighted average | DTLVS* 3,10,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | Prohibited, Carcinogen, JUL2008 | |
Occupational Exposure Limit-BELGIUM | Skin, MAR2002 | |
Occupational Exposure Limit-FRANCE | VME 0.001 ppm (0.007 mg/m3), C1 Carcinogen, FEB2006 | |
Occupational Exposure Limit-HUNGARY | ceiling concentration 10 mg/m3, Carcinogen, SEP2000 | |
Occupational Exposure Limit-JAPAN | 1 carc, MAY2012 | |
Occupational Exposure Limit-KOREA | carcinogen, skin, 2006 | |
Occupational Exposure Limit-NEW ZEALAND | carcinogen, skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.1 mg/m3, JAN1999 | |
Occupational Exposure Limit-SWEDEN | Group A Carcinogen, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | carc 1, JAN2011 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | see Code of Federal Regulations (CFR) 29,1926.1111 | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | see Code of Federal Regulations (CFR) 29,1910.1011 | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | see Code of Federal Regulations (CFR) 29,1915.1011 | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA)-cancer suspect agent | CFRGBR 29,1910.1011,1987 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-AMINODIPHENYL-air | Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1011 | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division