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Registry of Toxic Effects of Chemical Substances (RTECS)

Boric acid, disodium salt

RTECS #

ED4588000

CAS #

1330-43-4; 1332-28-1

Updated

September 201

Molecular Weight

201.22

Molecular Formula

B4O7·2Na

Synonyms

Anhydrous borax
Borates, tetra, sodium salt, anhydrous (ACGIH)
Borates, tetra, sodium salts (anhydrous)
Borax glass
Disodium tetraborate
FR 28
Fused borax
Rasorite 65
Sodium biborate
Sodium boron oxide
Sodium tetraborate
Sodium tetraborate (Na2B4O7)

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 16750 µg/kg (30D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands		EVHPAZ 13,59,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 2817 mg/kgVCVN1* -,193,1988
oral/mouse lethal dose (50 percent kill): 1060 mg/kgVCVN1* -,193,1988
oral/rat lethal dose (50 percent kill): 1200 mg/kgVCVN1* -,193,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 22680 mg/kg/12W- intermittentBlood: Luekopenia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count		VCVN1* -,195,1988
oral/rat lowest published toxic dose: 1312.5 mg/kg/70D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct		VCVN1* -,195,1988
oral/rat lowest published toxic dose: 283.5 mg/kg/70D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct		VCVN1* -,195,1988
oral/rat lowest published toxic dose: 26 gm/kg/14W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Xanthine, purine or nucleotides including urate		TOLED5 10,219,1982

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg/m3;short term exposure limit 6 mg/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,91,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg/m3, short term exposure limit 6 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg(B)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 1 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 1 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 mg/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M3899; Number of Industries 87; Total Number of Facilities 6225; Number of Occupations 57; Total Number of Employees Exposed 78116; Total Number of Female Employees Exposed 15080
National Occupational Hazard Survey 1974Hazard Code B0085; Number of Industries 34; Total Number of Facilities 1170; Number of Occupations 27; Total Number of Employees Exposed 5513
National Occupational Hazard Survey 1974Hazard Code M3899; Number of Industries 1; Total Number of Facilities 5; Number of Occupations 1; Total Number of Employees Exposed 101

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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