Registry of Toxic Effects of Chemical Substances (RTECS)
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1,3-Butadiene, 2-chloro-
RTECS #
EI9625000CAS #
126-99-8Updated
September 201Molecular Weight
88.54Molecular Formula
C4H5ClSynonyms
2-Chloor-1,3-butadieen (Dutch)2-Chlor-1,3-butadien (German)
2-Chloro-1,3-butadiene
2-Chloro-1,3-butadiene (OSHA)
2-Chlorobuta-1,3-diene
2-Cloro-1,3-butadiene (Italian)
beta-Chloroprene
beta-Chloroprene (ACGIH:OSHA)
Chlorobutadiene
Chloropreen (Dutch)
Chloropren (German, Polish)
Chloroprene
Cloroprene (Italian)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /rabbit | 500 µL/24H | severe | NTIS** OTS0535986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | unreported route/human | 1 mg/m3 | MUREAV 147,301,1985 |
| Cytogenetic Analysis | inhalation/rat | 1960 µg/m3/16W | BZARAZ 27(6),102,1974 |
| Cytogenetic Analysis | inhalation/mouse | 320 µg/m3/4W-continuous | GTPZAB 20(3),31,1976 |
| DNA Damage | inhalation/mouse | 32 ppm/104W- intermittent | CBINA8 135-136,373,2001 |
| Dominant Lethal Test | inhalation/rat | 4 µg/L/48D- intermittent | TNICS* 13,56,1973 |
| host-mediated assay | Salmonella typhimurium/mouse | 375 mg/kg/4H | ZKMAAX 16,41,1976 |
| micronucleus test | inhalation/mouse | 1480 µg/m3/2H/2D-continuous | HYDXET 17,209,1986 |
| morphological transform | embryo/hamster | 125 mg/L | AETODY 1,241,1980 |
| mutation in microorganisms | /Salmonella typhimurium | 70 µmol/L (+enzymatic activation step) | NATUAS 255,641,1975 |
| mutation in microorganisms | /Salmonella typhimurium | 2 pph/4H (-enzymatic activation step) | ARTODN 41,249,1979 |
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 5700 µmol/L/3D- intermittent | 35WYAM -,63,1976 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 4 mg/m3/24H (3-4D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | GTPZAB 19(3),30,1975 |
| inhalation/rat | 4 mg/m3/24H (11-12D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | GTPZAB 19(3),30,1975 |
| inhalation/rat | 10 ppm/4H (3-20D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TXAPA9 44,81,1978 |
| inhalation/rat | 150 µg/m3/24H (19W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EVHPAZ 17,85,1976 |
| inhalation/rat | 500 mg/m3/5H (17W prior to copulation) | Reproductive: Maternal effects: Menstrual cycle changes or disorders | BEBMAE 60(7),107,1965 |
| inhalation/rat | 500 mg/m3/5H (30W prior to copulation) | Reproductive: Maternal effects: Ovaries, fallopian tubes | BEBMAE 60(7),107,1965 |
| inhalation/rat | 0.15 mg/m3 (multigenerations) | Reproductive: Effects on embryo or fetus: Fetal death | VCVGH* -,505,1990 |
| inhalation/rat | 0.0038 gm/m3 (48D male) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | TPKVAL 13,58,1973 |
| oral/rat | 9100 µg/kg (26W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | GISAAA 45(2),17,1980 |
| oral/rat | 1 mg/kg (11-12D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | GTPZAB 19(3),30,1975 |
| oral/rat | 1 mg/kg (11-12D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | GTPZAB 19(7),30,1975 |
| oral/rat | 1 mg/kg (9-10D pregnant) | Reproductive: Other developmental abnormalities | GTPZAB 19(7),30,1975 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 32 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Lung, Thorax, or Respiration: Tumors | NTPTR* NTP-TR-467,1998 |
| inhalation/mouse | lowest published toxic concentration: 32 ppm/6H/104W - intermittent | Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | CBINA8 135-136,373,2001 |
| inhalation/mouse | lowest published toxic concentration: 80 ppm/5H/104W - intermittent | Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | CBINA8 135-136,373,2001 |
| inhalation/mouse | lowest published toxic concentration: 791.04 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | NTIS** PB99-123671 |
| inhalation/mouse | lowest published toxic concentration: 1977.6 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Liver: Tumors | NTIS** PB99-123671 |
| inhalation/rat | lowest published toxic concentration: 80 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors | NTPTR* NTP-TR-467,1998 |
| inhalation/rat | lowest published toxic concentration: 988.9 mg/kg/103W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Kidney, Ureter, and Bladder: Bladder tumors | NTIS** PB99-123671 |
| inhalation/rat | lowest published toxic concentration: 2060 mg/kg/103W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Endocrine: Thyroid tumors | NTIS** PB99-123671 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | Lowest published lethal concentration: 1290 mg/m3/8H | JIHTAB 18,240,1936 | |
| inhalation/cat | Lowest published lethal concentration: 3500 mg/m3/2H | VCVGH* -,504,1990 | |
| inhalation/human | lowest published toxic concentration: 100 mg/kg/5M | Eye: Lacrimation Behavioral: Headache Gastrointestinal: Nausea or vomiting | VCVGH* -,505,1990 |
| inhalation/mouse | lethal concentration (50 percent kill): 1600 mg/m3 | VCVGH* -,504,1990 | |
| inhalation/mouse | Lowest published lethal concentration: 600 mg/m3/8H | VCVGH* -,504,1990 | |
| inhalation/mouse | lethal concentration (50 percent kill): 2300 mg/m3/2H | VCVGH* -,504,1990 | |
| inhalation/rabbit | Lowest published lethal concentration: 6000 mg/m3/2H | VCVGH* -,504,1990 | |
| inhalation/rabbit | Lowest published lethal concentration: 3870 mg/m3/8H | JIHTAB 18,240,1936 | |
| inhalation/rat | lethal concentration (50 percent kill): 11800 mg/m3/4H | 85GMAT -,38,1982 | |
| inhalation/rat | lowest published toxic concentration: 17000 mg/kg/5H | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVGH* -,504,1990 |
| inhalation/rat | lethal concentration (50 percent kill): 300 mg/m3 | VCVGH* -,504,1990 | |
| intravenous/rabbit | lowest published lethal dose: 96 mg/kg | Blood: Other changes Skin: After systemic exposure: Dermatitis, other | SBLEA2 44,63,1942 |
| oral/mouse | lethal dose (50 percent kill): 146 mg/kg | 85GMAT -,38,1982 | |
| oral/rat | lethal dose (50 percent kill): 450 mg/kg | 85GMAT -,38,1982 | |
| subcutaneous/cat | lowest published lethal dose: 100 mg/kg | JIHTAB 18,240,1936 | |
| subcutaneous/mouse | lowest published lethal dose: 1 gm/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis | JIHTAB 18,240,1936 |
| subcutaneous/pigeon | lowest published lethal dose: 13 gm/kg | JIHTAB 18,240,1936 | |
| subcutaneous/rat | lowest published lethal dose: 500 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis | JIHTAB 18,240,1936 |
| unreported route/mouse | lethal dose (50 percent kill): 146 mg/kg | VCVGH* -,504,1990 | |
| unreported route/rat | lethal dose (50 percent kill): 119 mg/kg | VCVGH* -,504,1990 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/hamster | lowest published toxic concentration: 162 ppm/6H/4W- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 46,375,1978 |
| inhalation/hamster | lowest published toxic concentration: 50 ppm/6H/78W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | INHTE5 10,443,1998 |
| inhalation/mouse | lowest published toxic concentration: 3 ppm/5D- intermittent | Lung, Thorax, or Respiration: Other changes | TOXID9 -,207,2009 |
| inhalation/mouse | lowest published toxic dose: 1260 mg/m3/14D- intermittent | Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | ZYYZEW 3,125,1989 |
| inhalation/mouse | lowest published toxic concentration: 200 mg/m3/24H/91D- continuous | Gastrointestinal: Ulceration or bleeding from large intestine Blood: Changes in spleen Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JIHTAB 18,240,1936 |
| inhalation/rat | lowest published toxic concentration: 161 ppm/6H/4W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 46,375,1978 |
| inhalation/rat | lowest published toxic concentration: 220 µg/m3/24H/60D- continuous | Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | GISAAA 29(9),13,1964 |
| inhalation/rat | lowest published toxic concentration: 200 mg/m3/24H/91D- continuous | Brain and Coverings: Other degenerative changes Gastrointestinal: Ulceration or bleeding from large intestine Blood: Changes in spleen | JIHTAB 18,240,1936 |
| inhalation/rat | lowest published toxic concentration: 50 ppm/6H/2Y- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain | INHTE5 10,443,1998 |
| inhalation/rat | lowest published toxic concentration: 32 ppm/6H/16D- intermittent | Olfaction: Other olfaction effects | NTPTR* NTP-TR-467,1998 |
| inhalation/rat | lowest published toxic concentration: 0.039 gm/m3/48D- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition | TPKVAL 13,58,1973 |
| intraperitoneal/rat | lowest published toxic dose: 168 mg/kg/21D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver: Other changes Blood: Other changes | WDZAEK 6,126,1992 |
| oral/mouse | lowest published toxic dose: 63 mg/m3/21D- intermittent | Immunological Including Allergic: Decreased immune response | ZYYZEW 2,57,1988 |
| oral/rat | lowest published toxic dose: 9100 µg/kg/26W- intermittent | Liver: Changes in liver weight Endocrine: Changes in spleen weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | GISAAA 45(2),17,1980 |
| oral/rat | lowest published toxic dose: 1680 mg/kg/3W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | ZYYZEW 9,283,1995 |
| subcutaneous/mouse | lowest published toxic dose: 42 mg/kg/21D- intermittent | Immunological Including Allergic: Decreased immune response Biochemical: Metabolism (intermediary): Other proteins | ZYYZEW 2,57,1988 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm (skin) | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,227,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 19,131,1979 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 19,131,1979 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 71,227,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,227,1999 |
| TOXICOLOGY REVIEW | CTOXAO 13,153,1978 | |
| TOXICOLOGY REVIEW | CBINA8 135-136,27,2001 | |
| TOXICOLOGY REVIEW | CBINA8 135-136,81,2001 | |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | MUREAV 567,109,2004 | |
| TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
| TOXICOLOGY REVIEW | HETOEA 25,413,2006 | |
| TOXICOLOGY REVIEW | REPTED 25,192,2008 | |
| TOXICOLOGY REVIEW | MUREAV 566,49,2004 | |
| TOXICOLOGY REVIEW | MUREAV 682,94,2009 | |
| TOXICOLOGY REVIEW | NTAPM* -,629,1995 | |
| TOXICOLOGY REVIEW | MUREAV 751,49,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 25 ppm (90 mg/m3) (skin) | DTLVS* 3,54,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (36 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (18 mg/m3);KZW 20 ppm (72 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 ppm (37 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 1 ppm (3.6 mg/m3), skin, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 ppm (3.7 mg/m3), short term exposure limit 5 ppm (18 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 ppm (36 mg/m3), C2 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 18 mg/m3, short term exposure limit 72 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 1 ppm (3.6 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (35 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 ppm (45 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (36 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (3.6 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 ppm (36 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 2 mg/m3, short term exposure limit, 16 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 1 ppm (3.5 mg/m3);short term exposure limit 5 ppm (18 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (18 mg/m3), carc 2, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 18 mg/m3, Skin, 2003 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 25 ppm (90 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 25 ppm (90 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 25 ppm (90 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 25 ppm (90 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO beta-CHLOROPRENE-air | Carcinogen ceiling concentration 1 ppm | NIOSH* DHHS #95-121,1995 |
| National Occupational Exposure Survey 1983 | Hazard Code 18260; Number of Industries 17; Total Number of Facilities 1864; Number of Occupations 21; Total Number of Employees Exposed 17750; Total Number of Female Employees Exposed 654 | |
| National Occupational Hazard Survey 1974 | Hazard Code 18260; Number of Industries 39; Total Number of Facilities 3538; Number of Occupations 26; Total Number of Employees Exposed 43712 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Sperm morphology-rat | |
| EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal | |
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat | |
| NIOSH Analytical Method, 1994: beta-Chloroprene, 1002 | |
| NIOSH CURRENT INTELLIGENCE BULLETIN 1, 1975 | |
| NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen | |
| On EPA IRIS database | |
| OSHA ANALYTICAL METHOD #112 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division