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Registry of Toxic Effects of Chemical Substances (RTECS)

tert-Butyl alcohol

RTECS #

EO1925000

CAS #

75-65-0

Updated

September 201

Molecular Weight

74.14

Molecular Formula

C4H10O

Synonyms

1,1-Dimethylethanol
2-Methyl-2-propanol
2-Methylpropan-2-ol
2-Propanol, 2-methyl-
Alcool butylique tertiaire (French)
Arconol
Butanol tertiaire (French)
Butyl alcohol
Methanol, trimethyl-
NCI-C55367
t-Butanol
t-Butyl alcohol
t-Butyl hydroxide
tert-Butanol
tert-Butyl alcohol (OSHA)
Tertiary-Butyl alcohol
Trimethyl methanol
Trimethylcarbinol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/24H severeNTIS** OTS0572351
skin /rabbit 500 µL/24H mildNTIS** OTS0572351

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisparenteral/other insects12500 mg/kgENECEV 5,321,1989
mutation in microorganisms/Salmonella typhimurium2 mg/plate (+enzymatic activation step)MUREAV 446,15,1999

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 2000 ppm/7H (1-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 12,469,1989
inhalation/rat 3500 ppm/7H (1-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFAATDF 12,469,1989
oral/mouse 103 gm/kg (6-20D pregnant)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		JPETAB 222,294,1982
oral/mouse 135 gm/kg (6-20D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)JPETAB 222,294,1982
oral/mouse 20240 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)LIFSAK 45,1989,1989
oral/mouse 15000 mg/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects		VCVGK* -,103,1994

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 1540 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors		NTPTR* NTP-TR-436,1995
oral/mouse lowest published toxic dose: 749840 mg/kg/103W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors		NTIS** PB96-162748
oral/mouse lowest published toxic dose: 1521310 mg/kg/103W- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors		NTIS** PB96-162748
oral/mouse lowest published toxic dose: 749840 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV059 -,-,2002
oral/mouse lowest published toxic dose: 735420 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV059 -,-,2002
oral/rat lowest published toxic dose: 146 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors		NTPTR* NTP-TR-436,1995
oral/rat lowest published toxic dose: 302820 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV059 -,-,2002
oral/rat lowest published toxic dose: 144200 mg/kg/103W- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors		NTIS** PB96-162748
oral/rat lowest published toxic dose: 468650 mg/kg/103W- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors		NTIS** PB96-162748

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
eye/human lowest published toxic dose: 72.5 mg/m3Eye: Conjunctiva irritationVCVGK* -,103,1984
inhalation/rat lethal concentration (50 percent kill): >10000 ppm/4HBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Pulmonary emboli		NTIS** OTS0572351
inhalation/rat lethal concentration (50 percent kill): 14100 ppm/4HBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression		HPV059 -,-,2002
intraperitoneal/mouse lethal dose (50 percent kill): 399 mg/kgLiver: Other changesRCOCB8 26,75,1979
intraperitoneal/mouse lethal dose (50 percent kill): 900 mg/kgVCVGK* -,102,1984
intravenous/mouse lethal dose (50 percent kill): 1500 mg/kgVCVGK* -,102,1984
oral/rabbit lethal dose (50 percent kill): 3559 mg/kgEye: Corneal damage

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Dyspnea		IMSUAI 41,31,1972
oral/rabbit lethal dose (50 percent kill): 3600 mg/kgVCVGK* -,102,1984
oral/rabbit lowest published lethal dose: 3500 mg/kgVCVGK* -,102,1984
oral/rabbit lowest published toxic dose: 1408 mg/kgBehavioral: General anestheticHPV059 -,-,2002
oral/rabbit lethal dose (50 percent kill): 3558 mg/kgBehavioral: General anesthetic

Cardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression		HPV059 -,-,2002
oral/rat lethal dose (50 percent kill): 3500 mg/kgVCVGK* -,102,1984
oral/rat lethal dose (50 percent kill): 2733 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression		HPV059 -,-,2002
oral/rat lowest published toxic dose: 59 mg/kgBehavioral: WakefulnessHPV059 -,-,2002
oral/rat lowest published toxic dose: 530 mg/kgBehavioral: Wakefulness

Behavioral: Ataxia		HPV059 -,-,2002
oral/rat lethal dose (50 percent kill): 3500 mg/kgBehavioral: Wakefulness

Behavioral: Ataxia		HPV059 -,-,2002
oral/rat lethal dose (50 percent kill): 2743 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes		NTIS** OTS0572351
parenteral/frog lowest published lethal dose: 12 gm/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)		AIPTAK 50,296,1935
skin/guinea pig lethal dose (50 percent kill): >10 mL/kgSkin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair		NTIS** OTS0556680
skin/rabbit lethal dose (50 percent kill): >2 gm/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0572351
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgBlood: Hemorrhage

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV059 -,-,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 500 ppm/6H/5D- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes		ATSUDG 8,418,1985
oral/mouse lowest published toxic dose: 703 gm/kg/94D- continuousBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FAATDF 19,91,1992
oral/mouse lowest published toxic dose: 6 gm/kg/5D- intermittentRelated to Chronic Data: Changes in testicular weightNTIS** OTS0559651
oral/mouse lowest published toxic dose: 370360 mg/kg/94D- intermittentKidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV059 -,-,2002
oral/mouse lowest published toxic dose: 771740 mg/kg/94D- intermittentKidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV059 -,-,2002
oral/mouse lowest published toxic dose: 604420 mg/kg/94D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV059 -,-,2002
oral/mouse lowest published toxic dose: 1092280 mg/kg/94D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV059 -,-,2002
oral/rat lowest published toxic dose: 40950 mg/kg/65W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV059 -,-,2002
oral/rat lowest published toxic dose: 144200 mg/kg/103W- intermittentKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV059 -,-,2002
oral/rat lowest published toxic dose: 129780 mg/kg/103W- intermittentKidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight		HPV059 -,-,2002
oral/rat lowest published toxic dose: 468650 mg/kg/103W- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV059 -,-,2002
oral/rat lowest published toxic dose: 73176 mg/kg/21D- continuousBehavioral: Convulsions or effect on seizure threshold

Behavioral: Withdrawal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		PUOMA5 54,86,1976
oral/rat lowest published toxic dose: 150 gm/kg/94D- continuousBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FAATDF 19,91,1992
oral/rat lowest published toxic dose: 9545 µL/kg/10W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOLED5 80,97,1995

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWJACTDZ 8,627,1989
TOXICOLOGY REVIEWTOSCF2 61,1,2001
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWIJTOFN 24,1,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 659,68,2008
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 653,99,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (300 mg/m3)DTLVS* 3,32,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 100 ppm (303 mg/m3), short term exposure limit 150 ppm (455 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (62 mg/m3);KZW 80 ppm (248 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm (307 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 50 ppm (150 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (150 mg/m3), short term exposure limit 75 ppm (230 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 100 ppm (300 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 20 ppm (62 mg/m3), 2011
Occupational Exposure Limit-ICELANDshort term exposure limit 50 ppm (150 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 50 ppm (150 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 100 ppm (305 mg/m3), short term exposure limit 150 ppm (455 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 100 ppm (300 mg/m3);short term exposure limit 150 ppm (450 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 100 ppm (303 mg/m3); short term exposure limit 150 ppm (455 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (75 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (303 mg/m3); short term exposure limit 150 ppm (455 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 450 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (150 mg/m3);short term exposure limit 75 ppm (250 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (60 mg/m3), KZG-week 80 ppm (240 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 300 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 100 ppm (308 mg/m3);short term exposure limit 150 ppm (462 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (300 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (300 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (300 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (300 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO t-BUTYL ALCOHOL-air10H time-weighted average 100 ppm;short term exposure limit 150 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 14400; Number of Industries 128; Total Number of Facilities 10682; Number of Occupations 84; Total Number of Employees Exposed 171420; Total Number of Female Employees Exposed 26045
National Occupational Hazard Survey 1974Hazard Code 14400; Number of Industries 11; Total Number of Facilities 820; Number of Occupations 25; Total Number of Employees Exposed 3121

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: N crassa-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (water);equivocal evidence:mouse,rat
NIOSH Analytical Method, 1994: Alcohols I, 1400
NTP Carcinogenesis Studies (drinking water);some evidence:mouse,rat NTPTR* NTP-TR-436,1995
NTP Toxicity studies, RPT# TOX-53, October 2000

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