Registry of Toxic Effects of Chemical Substances (RTECS)
Camphor
RTECS #
EX1225000CAS #
76-22-2Updated
September 201Molecular Weight
152.26Molecular Formula
C10H16OSynonyms
1,7,7-Trimethylbicyclo(2.2.1)-2-heptanone2-Bornanone
2-Camphanone
2-Kamfanon (Czech)
2-Keto-1,7,7-trimethylnorcamphane
Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
Bornane, 2-oxo-
Camphor, natural
Camphor, synthetic
Camphor, synthetic (ACGIH:OSHA)
Formosa camphor
Gum camphor
Huile de camphre (French)
Japan camphor
Kampfer (German)
Laurel camphor
Matricaria camphor
Norcamphor, 1,7,7-trimethyl-
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
DNA Damage | kidney/monkey | 500 µmol/L/20H | FCTOD7 49,2035,2011 |
sister chromatid exchange | intraperitoneal/mouse | 80 mg/kg | MUREAV 224,157,1989 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | Lowest published lethal concentration: 400 mg/m3/3H | Behavioral: Muscle contraction or spasticity | GISAAA 22(11),83,1957 |
inhalation/mouse | lethal concentration (50 percent kill): 450 mg/m3 | Behavioral: Excitement Behavioral: Muscle contraction or spasticity Gastrointestinal: Nausea or vomiting | VCVPS* -,296,1998 |
inhalation/rat | lethal concentration (50 percent kill): 500 mg/m3 | VCVPS* -,296,1998 | |
intraperitoneal/cat | lowest published lethal dose: 400 mg/kg | HBAMAK 4,1289,1935 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 3 gm/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) Behavioral: Rigidity (includes catalepsy) | AJPAA4 30,857,1954 |
intraperitoneal/rat | lowest published lethal dose: 900 mg/kg | Behavioral: Convulsions or effect on seizure threshold | JPETAB 65,275,1939 |
oral/child | lowest published toxic dose: 51 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold | AJEMEN 7,41,1989 |
oral/Dog | lowest published lethal dose: 800 mg/kg | HBAMAK 4,1289,1935 | |
oral/infant | lowest published lethal dose: 70 mg/kg | Eye: Mydriasis (pupilliary dilation) Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands | AJPAA4 30,857,1954 |
oral/mouse | lethal dose (50 percent kill): 1310 mg/kg | SHGKA3 75,934,1975 | |
oral/rabbit | lowest published lethal dose: 2 gm/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) Behavioral: Rigidity (includes catalepsy) | AJPAA4 30,857,1954 |
subcutaneous/frog | lowest published lethal dose: 240 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | AEXPBL 50,199,1903 |
subcutaneous/mouse | lowest published lethal dose: 200 mg/kg | Behavioral: Excitement | HDTU** -,-,1933 |
subcutaneous/rat | lethal dose (50 percent kill): 70 mg/kg | CDGU** -,-,1934 | |
unreported route/child | lowest published lethal dose: 100 mg/kg | YKYUA6 31,1499,1980 | |
unreported route/human | lowest published toxic dose: 0.01 gm/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression | VCVPS* -,296,1998 |
unreported route/man | lowest published lethal dose: 29 mg/kg | 85DCAI 2,73,1970 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 210 mg/m3/3H/7W- intermittent | Lung, Thorax, or Respiration: Emphysema | GISAAA 22(11),83,1957 |
inhalation/rabbit | lowest published toxic concentration: 33 mg/m3/3H/7W- intermittent | Brain and Coverings: Other degenerative changes Cardiac: Other changes Lung, Thorax, or Respiration: Emphysema | GISAAA 22(11),83,1957 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm;short term exposure limit 3 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | JRPMAP 12,27,1974 | |
TOXICOLOGY REVIEW | NTIS** PB293-503 | |
TOXICOLOGY REVIEW | HUTOX* -,247,1996 | |
TOXICOLOGY REVIEW | CLLID* 13,277,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,267,1998 |
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 2 ppm (12 mg/m3) | DTLVS* 3,37,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 ppm (12 mg/m3), short term exposure limit 3 ppm (19 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 2 ppm (13 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 2 ppm (12 mg/m3), short term exposure limit 3 ppm (19 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 2 ppm (12 mg/m3), MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.3 ppm (1.9 mg/m3), short term exposure limit 0.9 ppm (5.7 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 2 ppm (12 mg/m3), FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 2 ppm (13 mg/m3), 2011 | |
Occupational Exposure Limit-ICELAND | time-weighted average 2 ppm (12 mg/m3), NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 2 ppm (12 mg/m3), short term exposure limit 3 ppm (18 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 2 ppm (12 mg/m3);short term exposure limit 3 ppm (19 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2 ppm (12 mg/m3); short term exposure limit 3 ppm (19 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 2 ppm (12 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 2 ppm (12.4 mg/m3); short term exposure limit 3 ppm (18.7 mg/m3), JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 3 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (13 mg/m3), JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 12 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 2 ppm, JAN1999 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 2 ppm (13 mg/m3);short term exposure limit 3 ppm (19 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 2 mg/m3 | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 2 mg/m3 | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 2 mg/m3 | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 2 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAMPHOR, synthetic-air | 10H time-weighted average 2 mg/m3 | NIOSH* DHHS #95-121,1995 |
National Occupational Exposure Survey 1983 | Hazard Code X1190; Number of Industries 1; Total Number of Facilities 25; Number of Occupations 1; Total Number of Employees Exposed 427; Total Number of Female Employees Exposed 176 | |
National Occupational Exposure Survey 1983 | Hazard Code 15800; Number of Industries 101; Total Number of Facilities 9166; Number of Occupations 87; Total Number of Employees Exposed 153554; Total Number of Female Employees Exposed 53187 | |
National Occupational Hazard Survey 1974 | Hazard Code 15800; Number of Industries 68; Total Number of Facilities 8356; Number of Occupations 63; Total Number of Employees Exposed 95578 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division