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Registry of Toxic Effects of Chemical Substances (RTECS)

Carbamoyl chloride, dimethyl-

RTECS #

FD4200000

CAS #

79-44-7

Updated

September 201

Molecular Weight

107.55

Molecular Formula

C3H6ClNO

Synonyms

(Dimethylamino)carbonyl chloride
Carbamic acid, dimethyl- (9CI)
Carbamyl chloride, N,N-dimethyl-
Chlorid kyseliny dimethylkarbaminove (Czech)
Chloroformic acid dimethylamide
Dimethyl carbamoyl chloride
Dimethyl carbamoyl chloride (ACGIH)
Dimethylamid kyseliny chlormravenci (Czech)
Dimethylcarbamic acid chloride
Dimethylcarbamic chloride
Dimethylcarbamidoyl chloride
Dimethylcarbamoyl chloride
Dimethylcarbamyl chloride
Dimethylchloroformamide
Dimethylkarbamoylchlorid (Czech)
N,N-Dimethylaminocarbonyl chloride
N,N-Dimethylcarbamic acid chloride
N,N-Dimethylcarbamidoyl chloride
N,N-Dimethylcarbamoyl chloride
N,N-Dimethylcarbamyl chloride
RCRA waste number U097
TL 389

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster33 µL/LPMRSDJ 1,551,1981
DNA repair/Escherichia coli10 mg/LJJIND8 62,873,1979
DNA repair/Saccharomyes cerevisiae136 µmol/LCNJGA8 24,771,1982
DNA repair/Schizosaccharomyces pombe136 µmol/LCNJGA8 24,771,1982
gene conversion and mitotic recombination/Saccharomyes cerevisiae2 gm/LPMRSDJ 1,481,1981
host-mediated assaySalmonella typhimurium/mouse1 gm/kgJJIND8 62,911,1979
micronucleus testintraperitoneal/mouse1400 µg/kgPMRSDJ 1,698,1981
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
morphological transformembryo/hamster100 µg/LIJCNAW 19,642,1977
mutation in mammalian somatic cellslymphocyte/mouse1200 mg/LPMRSDJ 1,580,1981
mutation in microorganismslymphocyte/mouse187 mg/L (+enzymatic activation step)MUREAV 97,49,1982
mutation in microorganisms/Saccharomyes cerevisiae89 mg/L (+enzymatic activation step)PMRSDJ 1,414,1981
mutation in microorganisms/Schizosaccharomyces pombe2 mg/L (+/-enzymatic activation step)PMRSDJ 1,424,1981
mutation in microorganisms/Salmonella typhimurium33 µg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Salmonella typhimurium300 ng/plate (-enzymatic activation step)ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms/Escherichia coli100 µg/plate (+/-enzymatic activation step)ENMUDM 6(Suppl 2),1,1984
other mutation test systems/Escherichia coli540 pmol/tubeMUREAV 147,79,1985
phage inhibition capacity/Escherichia coli500 µL/LPMRSDJ 1,224,1981
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster10 pphENMUDM 7,349,1985
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae100 mg/LPMRSDJ 1,468,1981
sister chromatid exchangeovary/hamster100 µmol/LMUREAV 118,103,1983
sister chromatid exchangelung/hamster100 µmol/LMUREAV 118,103,1983
Unscheduled DNA Synthesisfibroblast/human32 µg/LPMRSDJ 1,528,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 1 ppm/6H/89W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		JEPTDQ 4(1),107,1980
inhalation/hamster toxic concentration (other than lowest): 1 ppm/6H/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors		JEPTDQ 4(1),107,1980
inhalation/rat toxic concentration (other than lowest): 1 ppm/6H/6W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		PAACA3 21,106,1980
inhalation/rat toxic concentration (other than lowest): 1 ppmTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors		OHSLAM 6,5,1976
inhalation/rat lowest published toxic concentration: 1 ppm/6H/6W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors		CALEDQ 33,175,1986
intraperitoneal/mouse lowest published toxic dose: 2560 mg/kg/64W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application		JNCIAM 53,695,1974
skin/mouse lowest published toxic dose: 17280 mg/kg/72W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application		JACTDZ 6(4),479,1987
skin/mouse toxic dose: 13 gm/kg/55W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		JNCIAM 48,1539,1972
skin/mouse toxic dose: 13 gm/kg/55W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application		JNCIAM 53,695,1974
subcutaneous/mouse toxic dose: 8 gm/kg/40W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application		JNCIAM 53,695,1974
subcutaneous/mouse toxic dose: 5200 mg/kg/26W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application		JNCIAM 48,1539,1972
subcutaneous/mouse lowest published toxic dose: 894 mg/kg/52W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application		JACTDZ 6(4),479,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 1000 mg/m3/10MNDRC** NDCrc-132,OCT1942
inhalation/rat lethal concentration (50 percent kill): 180 ppm/6HJEPTDQ 4(1),107,1980
intraperitoneal/mouse lethal dose (50 percent kill): 300 mg/kgBehavioral: Somnolence (general depressed activity)ZAARAM 24,71,1974
oral/rat lethal dose (50 percent kill): 1 gm/kgBehavioral: Somnolence (general depressed activity)ZAARAM 24,71,1974

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.005 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 12,77,1976
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,531,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 12,77,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,531,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 71,531,1999
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLCARBAMOYLCHLORIDE-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 11, 1976
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database

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