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Registry of Toxic Effects of Chemical Substances (RTECS)

Coal-tar pitch

RTECS #

GF8655000

CAS #

65996-93-2

Updated

September 201

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Coal tar pitch volatiles (ACGIH:OSHA)
Pitch
Pitch, coal tar

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intratracheal/rat lowest published toxic dose: 1 gm/kg/10W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors		CRNGDP 13,233,1992
skin/mouse lowest published toxic dose: 36 gm/kg/18W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application		AJIMD8 2,59,1981
skin/mouse toxic dose: 4200 mg/kg/31W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application		TXAPA9 18,41,1971
skin/mouse toxic dose: 82 gm/kg/52W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		HYSAAV 33(4-6),180,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 880 mg/m3/7D- continuousEye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVPS* -,146,1998
inhalation/mouse lowest published toxic concentration: 50 mg/m3/4W- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVPS* -,146,1998
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/8W- intermittentBlood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation		VCVPS* -,131,1998
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/17W- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Normocytic anemia

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)		VCVPS* -,131,1998

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 35,83,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 35,83,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 3,22,1973
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMSUDL 7,174,1987
TOXICOLOGY REVIEWJIDHAN 5,462,1924
TOXICOLOGY REVIEWPAASAH 54,171,1959

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.2 mg/m3DTLVS* 3,57,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg/m3, carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.2 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 mg/m3, carc, NOV2011
Occupational Exposure Limit-JAPAN1 carc, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.02 mg/m3;short term exposure limit 0.015 ppm (0.03 mg/m3), 2004
Occupational Exposure Limit-PERUtime-weighted average 0.2 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 mg/m3, carc 2, inhal, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COAL TAR PRODUCTS-air10H time-weighted average 0.1 mg/m3 CHE fractionMMWR** 37(S-7),9,1988
National Occupational Exposure Survey 1983Hazard Code T0535; Number of Industries 20; Total Number of Facilities 1235; Number of Occupations 22; Total Number of Employees Exposed 19021; Total Number of Female Employees Exposed 98
National Occupational Hazard Survey 1974Hazard Code T0535; Number of Industries 4; Total Number of Facilities 190; Number of Occupations 6; Total Number of Employees Exposed 1354

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-58

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