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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyanamide, calcium salt (1:1)

RTECS #

GS6000000

CAS #

156-62-7

Updated

September 201

Molecular Weight

80.11

Molecular Formula

CN2·Ca

Synonyms

Alzodef
Calcium carbimide
Calcium cyanamid
Calcium cyanamide
Calcium cyanamide (ACGIH)
CCC
Cyanamid granular
Cyanamide calcique (French)
CY-L 500
Dormex
Lime-nitrogen
NCI-C02937
Nitrogen lime
Nitrolim
Nitrolime
USAF CY-2

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 170 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Vascular: Tumors		NCITR* NCI-TR-163,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >150 mg/m3/4H85JFAN A053,1984
inhalation/rat lowest published toxic concentration: 3000 mg/m3/20MBehavioral: Somnolence (general depressed activity)VCVN1* -,346,1988
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgNTIS** AD277-689
intravenous/mouse lethal dose (50 percent kill): 282 mg/kgNIIRDN 6,304,1982
intravenous/rat lethal dose (50 percent kill): 125 mg/kgNIIRDN 6,304,1982
oral/guinea pig lethal dose (50 percent kill): 220 mg/kgBehavioral: Irritability

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		VCVN1* -,346,1988
oral/human lowest published lethal dose: 571 mg/kg34ZIAG -,149,1969
oral/mouse lethal dose (50 percent kill): 334 mg/kgBehavioral: Irritability

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		VCVN1* -,346,1988
oral/mouse lethal dose (50 percent kill): 334 mg/kgNIIRDN 6,304,1982
oral/rabbit lethal dose (50 percent kill): 1400 mg/kgPCOC** -,174,1966
oral/rabbit lethal dose (50 percent kill): 350 mg/kgBehavioral: Irritability

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		VCVN1* -,346,1988
oral/rat lethal dose (50 percent kill): 158 mg/kgNIIRDN 6,304,1982
oral/rat lethal dose (50 percent kill): 250 mg/kgBehavioral: Irritability

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		VCVN1* -,346,1988
skin/rabbit lethal dose (50 percent kill): 590 mg/kg37ASAA 7,291,1979
unreported route/human lowest published lethal dose: 571.4 mg/kgVCVN1* -,346,1988
unreported route/rat lethal dose (50 percent kill): 1 gm/kgGUCHAZ 6,73,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 250 mg/kg/10D- intermittentBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)		VCVN1* -,347,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,299,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 1 mg/m3, inhal, skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg/m3, short term exposure limit 4 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3;short term exposure limit 1 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.5 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, KZG-week 1.0 mg/m3, resp, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg/m3;short term exposure limit 1 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CALCIUM CYANAMIDE-air10H time-weighted average 0.5 mg/m3NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 15730; Number of Industries 2; Total Number of Facilities 249; Number of Occupations 3; Total Number of Employees Exposed 4390
National Occupational Hazard Survey 1974Hazard Code 15730; Number of Industries 2; Total Number of Facilities 287; Number of Occupations 2; Total Number of Employees Exposed 12607

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-163,1979

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