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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexanol

RTECS #

GV7875000

CAS #

108-93-0

Updated

September 201

Molecular Weight

100.18

Molecular Formula

C6H12O

Synonyms

Adronal
Anol
Cicloesanolo (Italian)
Cyclohexanol (ACGIH:OSHA)
Cyclohexyl alcohol
Cykloheksanol (Polish)
Hexahydrophenol
Hexalin
Hydralin
Hydrophenol
Hydroxycyclohexane
Naxol
Phenol, hexahydro-

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 100 ppmJIHTAB 25,282,1943
eye /rabbit 100 µL/24H moderateNTIS** OTS0572833
eye /rabbit 100 µL/24H mildNTIS** OTS0572832
eye /rabbit 10 µL moderateJTPAE7 29,187,2001
skin /rabbit 500 µL/24H moderateNTIS** OTS0572833
skin /rabbit 500 µL/24H mildNTIS** OTS0572832

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human100 µmol/LDBTEAD 19,215,1971
DNA Damagelymphocyte/mammal (species unspecified)150 mmol/LPNASA6 48,686,1962
specific locus testother cell types/mouse2500 mg/LMUTAEX 15,45,2000

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat 315 mg/kg (21D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands		IJEBA6 17,1305,1979
subcutaneous/gerbil 315 mg/kg (21D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands		IJEBA6 17,1305,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
unreported route/rat lowest published toxic dose: 400 mg/kg/4D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens		MOCAE8 46,524,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 75 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes		JIHTAB 25,282,1943
inhalation/human lowest published toxic concentration: 400 mg/m3/3MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		VCVGK* -,129,1984
inhalation/mammal (species unspecified) lowest published toxic concentration: 1870 mg/m3/40MBrain and Coverings: Other degenerative changesVCVGK* -,129,1984
inhalation/mouse lowest published toxic concentration: 7 mg/m3Behavioral: General anestheticVCVGK* -,129,1984
inhalation/rat lowest published toxic concentration: 7 mg/m3Behavioral: General anestheticVCVGK* -,129,1984
inhalation/rat Lethal concentration: >6500 mg/m3/1HNTIS** OTS0572832
inhalation/rat lethal concentration (50 percent kill): >3630 mg/m3HPV188 -,-,2001
intramuscular/mouse lethal dose (50 percent kill): 1 gm/kgJSICAZ 21,342,1962
intraperitoneal/mouse lethal dose (50 percent kill): 1352 mg/kgARZNAD 19,1254,1969
intravenous/mouse lethal dose (50 percent kill): 272 mg/kgAIPTAK 135,330,1962
oral/rabbit lowest published lethal dose: 2200 mg/kgBehavioral: General anestheticJIHTAB 25,199,1943
oral/rabbit lowest published lethal dose: 2600 mg/kgVCVGK* -,129,1984
oral/rat lethal dose (50 percent kill): 1550 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis

Blood: Hemorrhage		HPV188 -,-,2001
oral/rat lethal dose (50 percent kill): 2060 mg/kgHPV188 -,-,2001
oral/rat lethal dose (50 percent kill): 1400 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0538617
parenteral/frog lowest published lethal dose: 1914 mg/kgCardiac: Other changesJPETAB 24,405,1925
skin/rabbit lowest published lethal dose: 794 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis

Liver: Other changes		HPV188 -,-,2001
skin/rabbit lowest published lethal dose: 794 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Change in gall bladder structure or function

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0538617

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 1229 ppm/6H/5W- intermittentBehavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JIHTAB 25,323,1943
inhalation/rabbit lowest published toxic concentration: 997 ppm/6H/11W- intermittentBehavioral: General anesthetic

Eye: Conjunctiva irritation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JIHTAB 25,323,1943
inhalation/rabbit lowest published toxic concentration: 4930 mg/m3/6H/5W- intermittentBehavioral: General anesthetic

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVGK* -,129,1994
inhalation/rabbit lowest published toxic concentration: 580 mg/m3/6H/5W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes		VCVGK* -,129,1994
inhalation/rat lowest published toxic concentration: 70 mg/m3/4H/122D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVGK* -,129,1994
inhalation/rat lowest published toxic concentration: 30 mg/m3/4H/134D- intermittentBlood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVGK* -,129,1994
intraperitoneal/rat lowest published toxic dose: 4 gm/kg/10D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTOLED5 45,271,1989
oral/rabbit lowest published toxic dose: 1000 mg/kg/40D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight		HPV188 -,-,2001
oral/rat lowest published toxic dose: 3185 mg/kg/7D- intermittentLiver: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other		HPV188 -,-,2001
oral/rat lowest published toxic dose: 3185 mg/kg/7D- continuousLiver: Other changes

Liver: Changes in liver weight		APTOA6 51,217,1982
skin/rabbit lowest published toxic dose: 50 mL/kg/1H/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,129,1994
subcutaneous/gerbil lowest published toxic dose: 315 mg/kg/21D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight		HPV188 -,-,2001
subcutaneous/rat lowest published toxic dose: 555 mg/kg/21D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight		HPV188 -,-,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWNTAPM* -,629,1995

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 50 ppm (200 mg/m3)DTLVS* 3,65,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (206 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (200 mg/m3);KZW 200 ppm (800 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (209 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (200 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (210 mg/m3), short term exposure limit 75 ppm (310 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (200 mg/m3), VLE 75 ppm (300 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 200 mg/m3, short term exposure limit 800 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (200 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 25 ppm (102 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (200 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (200 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (206 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (205 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 20 mg/m3, short term exposure limit 60 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 25 ppm, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (200 mg/m3);short term exposure limit 75 ppm (300 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 50 ppm (200 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (208 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (200 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (200 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (200 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (200 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXANOL-air10H time-weighted average 50 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 21560; Number of Industries 52; Total Number of Facilities 10121; Number of Occupations 66; Total Number of Employees Exposed 112365; Total Number of Female Employees Exposed 41412
National Occupational Hazard Survey 1974Hazard Code 21560; Number of Industries 56; Total Number of Facilities 6542; Number of Occupations 63; Total Number of Employees Exposed 65435

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9206
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

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