Registry of Toxic Effects of Chemical Substances (RTECS)
Cyclohexene
RTECS #
GW2500000CAS #
110-83-8Updated
September 201Molecular Weight
82.16Molecular Formula
C6H10Synonyms
1,2,3,4-TetrahydrobenzeneBenzene, tetrahydro-
Benzenetetrahydride
Cyclohex-1-ene
Cyclohexene (ACGIH:OSHA)
Cykloheksen (Polish)
Hexanaphthylene
Tetrahydrobenzene
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 30000 mg/m3 | Behavioral: General anesthetic | VCVGH* -,95,1990 |
inhalation/mouse | lethal concentration (50 percent kill): 50000 mg/m3 | Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Respiratory obstruction | VCVGH* -,95,1990 |
inhalation/rat | Lethal concentration: >6370 ppm/4H | Behavioral: Tremor Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes | NTIS** OTS0555329 |
inhalation/rat | Lethal concentration: >6370 ppm/4H | Behavioral: Tremor Behavioral: Ataxia | HPV158 -,-,2007 |
oral/mouse | lethal dose (50 percent kill): >3200 µL/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia | NTIS** OTS0546026 |
oral/mouse | lethal dose (50 percent kill): 2300 mg/kg | VCVGH* -,95,1990 | |
oral/rat | lethal dose (50 percent kill): 1300 mg/kg | VCVGH* -,95,1990 | |
oral/rat | lethal dose (16 percent kill): 920 mg/kg | VCVGH* -,95,1990 | |
oral/rat | lethal dose (84 percent kill): 3800 mg/kg | VCVGH* -,95,1990 | |
oral/rat | lowest published toxic dose: 400 mg/kg | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Nutritional and Gross Metabolic: Changes in: Metabolic acidosis Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | VCVGH* -,95,1990 |
oral/rat | lowest published lethal dose: 2000 mg/kg | Behavioral: Tremor Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Changes in structure or function of salivary glands | HPV158 -,-,2007 |
oral/rat | lethal dose (50 percent kill): 2400 µL/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Behavioral: Ataxia | NTIS** OTS0546026 |
skin/guinea pig | lethal dose (50 percent kill): >20 mL/kg | HPV158 -,-,2007 | |
unreported route/rat | lethal dose (50 percent kill): 2 gm/kg | GTPZAB 29(12),53,1985 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 600 ppm/6H/26W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | TXAPA9 37,155,1976 |
oral/rat | lowest published toxic dose: 7200 mg/kg/48D- intermittent | Gastrointestinal: Changes in structure or function of salivary glands | HPV158 -,-,2007 |
oral/rat | lowest published toxic dose: 24000 mg/kg/48D- intermittent | Gastrointestinal: Changes in structure or function of salivary glands Kidney, Ureter, and Bladder: Changes in kidney weight | HPV158 -,-,2007 |
oral/rat | lowest published toxic dose: 6300 mg/kg/42D- intermittent | Gastrointestinal: Changes in structure or function of salivary glands | HPV158 -,-,2007 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 300 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | ENTOX* -,707,2005 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 300 ppm (1015 mg/m3) | DTLVS* 3,66,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 300 ppm (1010 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 300 ppm (1015 mg/m3);KZW 1200 ppm (4060 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 300 ppm (1025 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 300 ppm (1015 mg/m3), MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 300 ppm (1000 mg/m3), short term exposure limit 380 ppm (1300 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 300 ppm (1015 mg/m3), FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 300 ppm (1015 mg/m3), NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 300 ppm (1050 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 300 ppm (1015 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 300 ppm (1.01 mg/m3), JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 300 ppm (1008 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 900 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 50 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 300 ppm (1015 mg/m3), JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1015 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 300 ppm (1015 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 300 ppm (1050 mg/m3), JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 300 ppm (1015 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 300 ppm (1015 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 300 ppm (1015 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 300 ppm (1015 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXENE-air | 10H time-weighted average 300 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 21705; Number of Industries 1; Total Number of Facilities 40; Number of Occupations 1; Total Number of Employees Exposed 517; Total Number of Female Employees Exposed 239 | |
National Occupational Hazard Survey 1974 | Hazard Code 21705; Number of Industries 1; Total Number of Facilities 16; Number of Occupations 7; Total Number of Employees Exposed 529 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division