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Registry of Toxic Effects of Chemical Substances (RTECS)

4-Cyclohexene-1,2-dicarboximide, N-((1,1,2,2-tetrachloroethyl)thio)-

RTECS #

GW4900000

CAS #

2425-06-1

Updated

September 201

Molecular Weight

349.06

Molecular Formula

C10H9Cl4NO2S

Synonyms

1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-((1,1,2,2-tetrachloroethyl)thio)- (9CI)
3a,4,7,7a-Tetrahydro-N-(1,1,2,2-tetrachloroethanesulphenyl)phthalimide
Alfloc 7020
Alfloc 7046
Arborseal
Captafol
Captafol (ACGIH)
CS5623
Difolatan
Difolatan 4F
Difolatan 80W
Difolatan BOW
Difosan
Folcid
Foltaf
Haipen 50
Merpafol
N-((1,1,2,2-Tetrachloroethyl)sulfenyl)-cis-4-cyclohexene-1,2-dicarboximide
N-(1,1,2,2-Tetrachloraethylthio)-cyclohex-4-en-1,4-diacarboximid (German)
N-(1,1,2,2-Tetrachloraethylthio)-tetrahydrophthalamid (German)
N-(1,1,2,2-Tetrachloroethylthio)-4-cyclohexene-1,2-dicarboximide
N-1,1,2,2-Tetrachloroethylmercapto-4-cyclohexene-1,2-carboximide
Nalco 7046
Ortho 5865
Proxel EF
Sanspor
Santar SM
Terrazol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 0.05%/48HCODEDG 17,212,1987

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisembryo/human3400 µg/LSNSHBT (20),574,1980
Cytogenetic Analysislung/hamster10 µmol/LMUREAV 78,177,1980
DNA Damagekidney/rat1 µmol/L/20HTXCYAC 204,187,2004
DNA Damageoral/rat1250 mg/kgTXCYAC 204,187,2004
DNA Damagekidney/human0.5 µmol/L/20HTXCYAC 204,187,2004
DNA inhibitionother cell types/rat80 mg/LARTODN 45,101,1980
DNA inhibitionlymphocyte/human5 mg/LARTODN 45,101,1980
DNA repair/Bacillus subtilis100 ng/discMUREAV 40,19,1976
Dominant Lethal Testintraperitoneal/rat25 mg/kg/5DFCTXAV 10,353,1972
gene conversion and mitotic recombination/Aspergillus nidulans20 µg/plateMUREAV 46,395,1977
micronucleus testembryo/human3400 µg/LSNSHBT (20),574,1980
micronucleus testlung/hamster3400 µg/LSNSHBT (20),574,1980
micronucleus testkidney/human1 µmol/L/48HTXCYAC 204,187,2004
micronucleus testkidney/rat0.5 µmol/L/48HTXCYAC 204,187,2004
micronucleus testoral/rat1250 mg/kgTXCYAC 204,187,2004
morphological transformoral/rat7560 mg/kg/6WCRNGDP 9,387,1988
mutation in microorganisms/Aspergillus nidulans20 µg/plate (-enzymatic activation step)MUREAV 46,395,1977
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)EMCAE8 5,11,1985
mutation in microorganisms/Escherichia coli50 µg/plate (-enzymatic activation step)MUREAV 40,19,1976
mutation in microorganisms/Escherichia coli50 µg/plate (+enzymatic activation step)MUREAV 116,185,1983
other mutation test systems/Escherichia coli100 µg/LMUREAV 390,245,1997
sister chromatid exchangeembryo/human3400 µg/LSNSHBT (20),574,1980
sister chromatid exchangelung/hamster2 µmol/LMUREAV 78,177,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 500 mg/kg (5D male)Reproductive: Effects on embryo or fetus: Fetal deathFCTXAV 10,363,1972
oral/rabbit 975 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXAPA9 13,420,1968
oral/hamster 200 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system		TXAPA9 16,24,1970
oral/hamster 400 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTXAPA9 16,24,1970
oral/rat 11 gm/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TXAPA9 13,420,1968
oral/rat 250 mg/kg (5D male)Reproductive: Effects on embryo or fetus: Fetal deathFCTXAV 10,363,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 60480 mg/kg/96W- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors		GANNA2 75,853,1984
oral/mouse toxic dose: 15120 mg/kg/96W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Cardiac: Tumors

Gastrointestinal: Tumors		JTSCDR 7,278,1982
oral/rat lowest published toxic dose: 65520 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors		JJCREP 81,1222,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published lethal dose: 3 mg/kgFCTXAV 13,55,1975
oral/rat lethal dose (50 percent kill): 2500 mg/kgWRPCA2 9,119,1970
skin/rabbit lethal dose (50 percent kill): 15400 mg/kgENTOX* -,407,2005
unreported route/rat lethal dose (50 percent kill): >6 gm/kgRREVAH 36,240,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 45360 mg/kg/12W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight		JTEHD6 38,69,1993
oral/rat lowest published toxic dose: 39894.4 mg/kg/104W- continuousLiver: TumorsHBPTO* 1,814,2001
oral/rat lowest published toxic dose: 39894.4 mg/kg/104W- continuousKidney, Ureter, and Bladder: Kidney tumorsHBPTO* 1,814,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 53,353,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 53,353,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 53,353,1991
TOXICOLOGY REVIEWMUREAV 32,3,1975
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWENTOX* -,407,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWFCTOD7 46,813,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,93,1998
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.1 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, carc, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.1 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, inhal, skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPTAFOL-air10H Carcinogen time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974Hazard Code M2985; Number of Industries 1; Total Number of Facilities 59; Number of Occupations 1; Total Number of Employees Exposed 117

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-aneuploidy; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-recombination; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: TRP reversion
EPA GENETOX PROGRAM 1988, Weakly Positive: TRP reversion
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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